$873 Cheap Flights from Madrid (MAD) to São Tomé Island (TMS)

View $873 flight on Sun, Dec 7, 2025Opens in a new window

Popular airlines from Adolfo Suarez Madrid-Barajas Airport (MAD) to São Tomé Island (TMS-São Tomé Intl.)

Cheap Flights from Madrid to São Tomé Island (MAD-TMS)

Prices were available within the past 7 days and start at $873 for one-way flights and $971 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

TAP Portugal
Sun, Feb 8 - Wed, Feb 18
MAD
Madrid
TMS
São Tomé Island
$971 Roundtrip, found 3 days ago
$971
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Feb 8 from Madrid to São Tomé Island, returning Wed, Feb 18, priced at $971 found 3 days ago
TAP Portugal
Sun, Feb 8 - Wed, Feb 18
MAD
Madrid
TMS
São Tomé Island
$1,043 Roundtrip, found 3 days ago
$1,043
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Feb 8 from Madrid to São Tomé Island, returning Wed, Feb 18, priced at $1,043 found 3 days ago
TAP Portugal
Sun, Feb 8 - Wed, Feb 18
MAD
Madrid
TMS
São Tomé Island
$1,138 Roundtrip, found 3 days ago
$1,138
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Feb 8 from Madrid to São Tomé Island, returning Wed, Feb 18, priced at $1,138 found 3 days ago
TAP Portugal
Sun, Feb 8 - Wed, Feb 18
MAD
Madrid
TMS
São Tomé Island
$1,234 Roundtrip, found 3 days ago
$1,234
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Feb 8 from Madrid to São Tomé Island, returning Wed, Feb 18, priced at $1,234 found 3 days ago
TAP Portugal
Wed, Dec 31 - Wed, Jan 14
MAD
Madrid
TMS
São Tomé Island
$1,243 Roundtrip, found 6 days ago
$1,243
Roundtrip
found 6 days ago
Select TAP Portugal flight, departing Wed, Dec 31 from Madrid to São Tomé Island, returning Wed, Jan 14, priced at $1,243 found 6 days ago
TAP Portugal
Sun, Dec 7 - Sat, Dec 20
MAD
Madrid
TMS
São Tomé Island
$1,299 Roundtrip, found 3 days ago
$1,299
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Dec 7 from Madrid to São Tomé Island, returning Sat, Dec 20, priced at $1,299 found 3 days ago
TAP Portugal
Wed, Dec 31 - Sat, Jan 10
MAD
Madrid
TMS
São Tomé Island
$1,316 Roundtrip, found 6 days ago
$1,316
Roundtrip
found 6 days ago
Select TAP Portugal flight, departing Wed, Dec 31 from Madrid to São Tomé Island, returning Sat, Jan 10, priced at $1,316 found 6 days ago
TAP Portugal
Sun, Dec 7 - Sat, Dec 20
MAD
Madrid
TMS
São Tomé Island
$1,347 Roundtrip, found 3 days ago
$1,347
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sun, Dec 7 from Madrid to São Tomé Island, returning Sat, Dec 20, priced at $1,347 found 3 days ago
Ethiopian Airlines
Mon, Dec 29 - Sun, Jan 11
MAD
Madrid
TMS
São Tomé Island
$1,441 Roundtrip, found 6 days ago
$1,441
Roundtrip
found 6 days ago
Select Ethiopian Airlines flight, departing Mon, Dec 29 from Madrid to São Tomé Island, returning Sun, Jan 11, priced at $1,441 found 6 days ago
Iberia
Tue, Dec 30 - Mon, Jan 12
MAD
Madrid
TMS
São Tomé Island
$1,523 Roundtrip, found 6 days ago
$1,523
Roundtrip
found 6 days ago
Select Iberia flight, departing Tue, Dec 30 from Madrid to São Tomé Island, returning Mon, Jan 12, priced at $1,523 found 6 days ago

Frequently asked questions

How much does a flight from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS) cost?
Snag a cheap one-way flight from $873 or cheap return flight from $971 from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS)?
February is the cheapest month to fly from MAD to TMS. Traveling during an off-peak travel window is often the key to scoring lower fares.
What is the cheapest airline that flies from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from MAD to TMS. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS)?
There aren't any daily nonstop flights from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from MAD to TMS?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS)?
To avoid potential delays on the Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS) last-minute?
Holding off until right before your break to book a flight from MAD to TMS generally means paying more. Although you may find some last-minute offers, there's no guarantee. Keep your travel plans flexible to maximize your chances of getting a bargain.
Is it cheaper to book a MAD to TMS flight and hotel package?
Compared with arranging flights and hotels separately, booking a MAD to TMS flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place will take the hassle out of travel planning. Simply secure your flights and choose from our extensive range of stays, then tailor your trip with other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Adolfo Suarez Madrid-Barajas Airport (MAD) to Sao Tome Intl. Airport (TMS)?
Usually, it's possible to reschedule or cancel your MAD to TMS flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Travel information

Origin airport
Adolfo Suárez Madrid-Barajas
Destination airport
São Tomé Intl.
Roundtrip price
$970
Distance
2844 mi

Book with confidence

Book with confidence

Madrid to São Tomé Island Flights

The cheapest times to fly from Madrid to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Madrid to São Tomé Island are during the month of February. You can find some of the cheapest flights from Madrid to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Madrid to São Tomé Island

Sunday is one of the best days to book for cheap flights from Madrid to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Madrid to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Madrid to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $873 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Madrid to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Madrid to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Madrid to São Tomé Island Flights
*Available to One Key members.