$375 Cheap Flights from Medellín (MDE) to Greenville (GSP)

View $375 flight on Wed, Jan 21, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP)

Cheap Flights from Medellín to Greenville (MDE-GSP)

Prices were available within the past 7 days and start at $375 for one-way flights and $558 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Mon, Dec 15 - Wed, Dec 31
MDE
Medellin
GSP
Greenville
$558 Roundtrip, found 4 days ago
$558
Roundtrip
found 4 days ago
Select United flight, departing Mon, Dec 15 from Medellin to Greenville, returning Wed, Dec 31, priced at $558 found 4 days ago
American Airlines
Wed, Feb 4 - Thu, Mar 19
MDE
Medellin
GSP
Greenville
$558 Roundtrip, found 22 hours ago
$558
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Wed, Feb 4 from Medellin to Greenville, returning Thu, Mar 19, priced at $558 found 22 hours ago
American Airlines
Tue, Feb 3 - Mon, Mar 16
MDE
Medellin
GSP
Greenville
$563 Roundtrip, found 5 days ago
$563
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Feb 3 from Medellin to Greenville, returning Mon, Mar 16, priced at $563 found 5 days ago
American Airlines
Tue, Feb 10 - Mon, Mar 2
MDE
Medellin
GSP
Greenville
$563 Roundtrip, just found
$563
Roundtrip
just found
Select American Airlines flight, departing Tue, Feb 10 from Medellin to Greenville, returning Mon, Mar 2, priced at $563 just found
American Airlines
Tue, Feb 10 - Mon, Mar 2
MDE
Medellin
GSP
Greenville
$568 Roundtrip, just found
$568
Roundtrip
just found
Select American Airlines flight, departing Tue, Feb 10 from Medellin to Greenville, returning Mon, Mar 2, priced at $568 just found
American Airlines
Thu, Feb 26 - Sat, Mar 28
MDE
Medellin
GSP
Greenville
$568 Roundtrip, found 2 days ago
$568
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Feb 26 from Medellin to Greenville, returning Sat, Mar 28, priced at $568 found 2 days ago
United
Fri, Jan 23 - Tue, Feb 3
MDE
Medellin
GSP
Greenville
$569 Roundtrip, found 4 days ago
$569
Roundtrip
found 4 days ago
Select United flight, departing Fri, Jan 23 from Medellin to Greenville, returning Tue, Feb 3, priced at $569 found 4 days ago
LATAM Airlines Group
Thu, Feb 5 - Mon, Mar 16
MDE
Medellin
GSP
Greenville
$591 Roundtrip, found 5 days ago
$591
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Feb 5 from Medellin to Greenville, returning Mon, Mar 16, priced at $591 found 5 days ago
Copa
Tue, Feb 3 - Tue, Mar 17
MDE
Medellin
GSP
Greenville
$704 Roundtrip, found 1 day ago
$704
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, Feb 3 from Medellin to Greenville, returning Tue, Mar 17, priced at $704 found 1 day ago
Delta
Thu, Feb 26 - Sat, Mar 28
MDE
Medellin
GSP
Greenville
$813 Roundtrip, found 2 days ago
$813
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Feb 26 from Medellin to Greenville, returning Sat, Mar 28, priced at $813 found 2 days ago

Find the cheapest month to fly from Medellín (MDE) to Greenville (GSP)

February is typically the cheapest month to fly

From $514 - $1,027 per traveler.

Alternative airports near Greenville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Greenville-Spartanburg Intl. GSP. Cheapest option available. Average driving time to city center is 18 minutes. Flights from $691
GSP
Greenville-Spartanburg Intl.
Cheapest
Average driving time to city center18 min
Flights from $691
Flights from Medellín (MDE) to Greenville (GSP)
Origin airport
José María Córdova Intl.
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
American Airlines, Copa, Delta, LATAM Airlines Group, United
Roundtrip price
$558
Distance
2030 mi

Medellín to Greenville Flights

The cheapest times to fly from Medellín to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Greenville are during the month of December. You can find some of the cheapest flights from Medellín to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Greenville

Sunday is one of the best days to book for cheap flights from Medellín to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $375 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP) cost?
Grab a cheap one-way flight from $375 or cheap return flight from $558 from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP)?
The cheapest month to fly from MDE to GSP is December, when demand is low. Off-peak season is usually when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP)?
To find the cheapest airline that'll fly you from MDE to GSP, use Expedia's filter tool. Tailor your search based on your travel style, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP)?
There aren't any daily direct flights from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from MDE to GSP?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a range of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP)?
Opt for a flight from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP) last-minute?
Last-minute fares from MDE to GSP are usually more expensive. For the best prices, start searching for flights well in advance. That said, if your travel plans are flexible, you may find a cheap ticket right before your trip.
Is it cheaper to book a MDE to GSP flight and hotel package?
You'll typically save money by booking a MDE to GSP flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've chosen your ideal accommodations and flights, consider adding extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Greenville-Spartanburg Intl. Airport (GSP)?
It's usually possible to cancel or reschedule your MDE to GSP flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.