$226 Cheap Flights from Manchester (MHT) to Panama City (PTY)

View $226 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Manchester to Panama City (MHT-PTY)

Prices were available within the past 7 days and start at $226 for one-way flights and $522 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 5 - Tue, Nov 18
MHT
Manchester
PTY
Panama City
$522 Roundtrip, found 7 hours ago
$522
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Manchester to Panama City, returning Tue, Nov 18, priced at $522 found 7 hours ago
American Airlines
Wed, Sep 3 - Sat, Sep 6
MHT
Manchester
PTY
Panama City
$529 Roundtrip, found 2 days ago
$529
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Sep 3 from Manchester to Panama City, returning Sat, Sep 6, priced at $529 found 2 days ago
American Airlines
Wed, Oct 22 - Mon, Oct 27
MHT
Manchester
PTY
Panama City
$531 Roundtrip, found 1 day ago
$531
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Manchester to Panama City, returning Mon, Oct 27, priced at $531 found 1 day ago
American Airlines
Wed, Nov 5 - Wed, Nov 19
MHT
Manchester
PTY
Panama City
$539 Roundtrip, found 6 hours ago
$539
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Manchester to Panama City, returning Wed, Nov 19, priced at $539 found 6 hours ago
American Airlines
Wed, Nov 5 - Tue, Nov 18
MHT
Manchester
PTY
Panama City
$540 Roundtrip, found 7 hours ago
$540
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Manchester to Panama City, returning Tue, Nov 18, priced at $540 found 7 hours ago
American Airlines
Wed, Oct 22 - Mon, Oct 27
MHT
Manchester
PTY
Panama City
$541 Roundtrip, found 1 day ago
$541
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Manchester to Panama City, returning Mon, Oct 27, priced at $541 found 1 day ago
American Airlines
Wed, Oct 22 - Mon, Oct 27
MHT
Manchester
PTY
Panama City
$542 Roundtrip, found 1 day ago
$542
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Manchester to Panama City, returning Mon, Oct 27, priced at $542 found 1 day ago
American Airlines
Wed, Nov 5 - Wed, Nov 19
MHT
Manchester
PTY
Panama City
$544 Roundtrip, found 6 hours ago
$544
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Manchester to Panama City, returning Wed, Nov 19, priced at $544 found 6 hours ago
American Airlines
Wed, Oct 22 - Mon, Oct 27
MHT
Manchester
PTY
Panama City
$548 Roundtrip, found 1 day ago
$548
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Manchester to Panama City, returning Mon, Oct 27, priced at $548 found 1 day ago
United
Fri, Aug 15 - Wed, Aug 20
MHT
Manchester
PTY
Panama City
$554 Roundtrip, found 3 days ago
$554
Roundtrip
found 3 days ago
Select United flight, departing Fri, Aug 15 from Manchester to Panama City, returning Wed, Aug 20, priced at $554 found 3 days ago
Flights from Manchester (MHT) to Panama City (PTY)
Origin airport
Manchester-Boston Regional
Destination airport
Tocumen Intl.
Roundtrip price
$521
Distance
2388 mi

Manchester to Panama City Flights

The cheapest times to fly from Manchester to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Manchester to Panama City are during the month of November. You can find some of the cheapest flights from Manchester to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Manchester to Panama City

Sunday is one of the best days to book for cheap flights from Manchester to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Manchester to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Manchester to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $226 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Manchester to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Manchester to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from MHT to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MHT to PTY?
The cheapest flights from MHT to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY)?
There are no direct flights from Manchester, NH (MHT-Manchester-Boston Regional) to Tocumen Intl. Airport (PTY). However, you'll find other airports with nonstop flights. Hop on your plane at Logan Intl. Airport (BOS) and fly straight to Panama City without a layover.
What is the cheapest airline that flies from MHT to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MHT to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY)?
Direct flights from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MHT to PTY?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY)?
Select a flight from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from MHT to PTY right before your journey is usually more expensive. But if you're flexible with your itinerary, you could bag a cheap last-minute fare.
Is it cheaper to book a MHT to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a MHT to PTY flight and hotel package with Expedia could result in significant savings. Better still, managing everything in one place takes the hassle out of travel planning. Simply secure your flights and choose from our wide range of stays, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Manchester-Boston Regional Airport (MHT) to Tocumen Intl. Airport (PTY)?
Typically, you're able to cancel or reschedule your MHT to PTY flight. However, additional fees may apply, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you'd like more information, head to our Customer Service portal.

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*Available to One Key members.