$699 Cheap Flights from Mexicali (MXL) to Panama City (PTY)

View $699 flight on Tue, Jun 23, 2026Opens in a new window

Popular airlines from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Mexicali to Panama City (MXL-PTY)

Prices were available within the past 7 days and start at $699 for one-way flights and $854 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Thu, Feb 18 - Mon, Feb 22
MXL
Mexicali
PTY
Panama City
$854 Roundtrip, found 2 days ago
$854
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Thu, Feb 18 from Mexicali to Panama City, returning Mon, Feb 22, priced at $854 found 2 days ago
Aeromexico
Tue, Jun 23 - Tue, Jun 30
MXL
Mexicali
PTY
Panama City
$859 Roundtrip, found 15 hours ago
$859
Roundtrip
found 15 hours ago
Select Aeromexico flight, departing Tue, Jun 23 from Mexicali to Panama City, returning Tue, Jun 30, priced at $859 found 15 hours ago
Aeromexico
Tue, Jun 23 - Tue, Jun 30
MXL
Mexicali
PTY
Panama City
$885 Roundtrip, found 15 hours ago
$885
Roundtrip
found 15 hours ago
Select Aeromexico flight, departing Tue, Jun 23 from Mexicali to Panama City, returning Tue, Jun 30, priced at $885 found 15 hours ago
Aeromexico
Tue, Jun 23 - Tue, Jun 30
MXL
Mexicali
PTY
Panama City
$911 Roundtrip, found 15 hours ago
$911
Roundtrip
found 15 hours ago
Select Aeromexico flight, departing Tue, Jun 23 from Mexicali to Panama City, returning Tue, Jun 30, priced at $911 found 15 hours ago
Aeromexico
Tue, Jun 23 - Tue, Jun 30
MXL
Mexicali
PTY
Panama City
$937 Roundtrip, found 15 hours ago
$937
Roundtrip
found 15 hours ago
Select Aeromexico flight, departing Tue, Jun 23 from Mexicali to Panama City, returning Tue, Jun 30, priced at $937 found 15 hours ago
Aeromexico
Thu, Feb 18 - Mon, Feb 22
MXL
Mexicali
PTY
Panama City
$947 Roundtrip, found 2 days ago
$947
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Thu, Feb 18 from Mexicali to Panama City, returning Mon, Feb 22, priced at $947 found 2 days ago
Aeromexico
Thu, Jun 11 - Thu, Jun 18
MXL
Mexicali
PTY
Panama City
$964 Roundtrip, found 2 days ago
$964
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Thu, Jun 11 from Mexicali to Panama City, returning Thu, Jun 18, priced at $964 found 2 days ago
Aeromexico
Thu, Jun 11 - Thu, Jun 18
MXL
Mexicali
PTY
Panama City
$990 Roundtrip, found 2 days ago
$990
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Thu, Jun 11 from Mexicali to Panama City, returning Thu, Jun 18, priced at $990 found 2 days ago
Aeromexico
Thu, Feb 18 - Mon, Feb 22
MXL
Mexicali
PTY
Panama City
$999 Roundtrip, found 2 days ago
$999
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Thu, Feb 18 from Mexicali to Panama City, returning Mon, Feb 22, priced at $999 found 2 days ago
Aeromexico
Thu, Feb 18 - Mon, Feb 22
MXL
Mexicali
PTY
Panama City
$1,036 Roundtrip, found 6 days ago
$1,036
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Feb 18 from Mexicali to Panama City, returning Mon, Feb 22, priced at $1,036 found 6 days ago
Aeromexico
Thu, Feb 18 - Mon, Feb 22
MXL
Mexicali
PTY
Panama City
$1,039 Roundtrip, found 2 days ago
$1,039
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Thu, Feb 18 from Mexicali to Panama City, returning Mon, Feb 22, priced at $1,039 found 2 days ago
Copa
Thu, Jun 11 - Thu, Jun 18
MXL
Mexicali
PTY
Panama City
$1,167 Roundtrip, found 2 days ago
$1,167
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, Jun 11 from Mexicali to Panama City, returning Thu, Jun 18, priced at $1,167 found 2 days ago

Frequently asked questions

How much does a flight from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) cost?
You can find cheap one-way flights from $699 and cheap return flights from $854 Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) with Expedia. Roundtrip flights usually range from $924 to $2822. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
The cheapest month to fly from MXL to PTY is February when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
Enter MXL to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) usually departs at around 12:45 AM, operated by Aeromexico. This seasonal service is active in June, giving you an early start to your travels. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
The busiest day for flights from General Rodolfo Sanchez Taboada Intl. (MXL) to Tocumen Intl. (PTY) is a Wednesday, with around 6 flights. This gives you plenty of options for your travel plans. A major airline on this route is Aeromexico.
What are the most popular departure times for flights from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Mexicali (MXL) to Panama City (PTY) are in the evening, from 6pm to 9pm. This time window accounts for about 53% of total traffic. Many major carriers, including Aeroméxico, operate flights during this time. This timing is popular as it allows travelers to arrive in Panama City in the late evening, ready for the next day's adventures.
How long does it take to fly from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
Flying from MXL to PTY with a connection usually takes about 10 hours, traveling roughly 2,807 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
Business class seats are offered on the MXL to PTY route with Aeromexico.
How do I earn miles on a Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from General Rodolfo Sanchez Taboada Intl. (MXL)?
From General Rodolfo Sanchez Taboada Intl. (MXL), you can fly into Tocumen Intl. (PTY) to reach Panama City. Some flights may connect through major hubs like Mexico City Intl. (MEX) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
General Rodolfo Sanchez Taboada Intl.
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, Copa
Roundtrip price
$853
Distance
2806 mi

Book with confidence

Mexicali to Panama City Flights

The cheapest times to fly from Mexicali to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexicali to Panama City are during the month of February. You can find some of the cheapest flights from Mexicali to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexicali to Panama City

Sunday is one of the best days to book for cheap flights from Mexicali to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexicali to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexicali to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $699 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexicali to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexicali to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mexicali to Panama City Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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