$540 Cheap Flights from Panama City (PTY) to Lisbon (LIS)

View $540 flight on Mon, Nov 10, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)

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Cheap Flights from Panama City to Lisbon (PTY-LIS)

Prices were available within the past 7 days and start at $540 for one-way flights and $738 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

KLM
Thu, Dec 4 - Sat, Jan 17
PTY
Panama City
LIS
Lisbon
$738 Roundtrip, found 1 day ago
$738
Roundtrip
found 1 day ago
Select KLM flight, departing Thu, Dec 4 from Panama City to Lisbon, returning Sat, Jan 17, priced at $738 found 1 day ago
KLM
Thu, Nov 20 - Wed, Nov 26
PTY
Panama City
LIS
Lisbon
$751 Roundtrip, found 5 days ago
$751
Roundtrip
found 5 days ago
Select KLM flight, departing Thu, Nov 20 from Panama City to Lisbon, returning Wed, Nov 26, priced at $751 found 5 days ago
KLM
Mon, Nov 24 - Wed, Nov 26
PTY
Panama City
LIS
Lisbon
$751 Roundtrip, found 5 days ago
$751
Roundtrip
found 5 days ago
Select KLM flight, departing Mon, Nov 24 from Panama City to Lisbon, returning Wed, Nov 26, priced at $751 found 5 days ago
Air Europa
Mon, Apr 27 - Mon, May 11
PTY
Panama City
LIS
Lisbon
$765 Roundtrip, found 5 days ago
$765
Roundtrip
found 5 days ago
Select Air Europa flight, departing Mon, Apr 27 from Panama City to Lisbon, returning Mon, May 11, priced at $765 found 5 days ago
Air France
Mon, Feb 2 - Tue, Feb 10
PTY
Panama City
LIS
Lisbon
$772 Roundtrip, found 2 days ago
$772
Roundtrip
found 2 days ago
Select Air France flight, departing Mon, Feb 2 from Panama City to Lisbon, returning Tue, Feb 10, priced at $772 found 2 days ago
Turkish Airlines
Wed, Mar 11 - Sun, Mar 29
PTY
Panama City
LIS
Lisbon
$782 Roundtrip, found 5 days ago
$782
Roundtrip
found 5 days ago
Select Turkish Airlines flight, departing Wed, Mar 11 from Panama City to Lisbon, returning Sun, Mar 29, priced at $782 found 5 days ago
Air France
Tue, Nov 18 - Wed, Dec 3
PTY
Panama City
LIS
Lisbon
$786 Roundtrip, found 5 days ago
$786
Roundtrip
found 5 days ago
Select Air France flight, departing Tue, Nov 18 from Panama City to Lisbon, returning Wed, Dec 3, priced at $786 found 5 days ago
Iberia
Sun, May 24 - Fri, Jun 12
PTY
Panama City
LIS
Lisbon
$795 Roundtrip, found 1 hour ago
$795
Roundtrip
found 1 hour ago
Select Iberia flight, departing Sun, May 24 from Panama City to Lisbon, returning Fri, Jun 12, priced at $795 found 1 hour ago
Air Europa
Fri, May 8 - Sun, May 24
PTY
Panama City
LIS
Lisbon
$797 Roundtrip, found 1 hour ago
$797
Roundtrip
found 1 hour ago
Select Air Europa flight, departing Fri, May 8 from Panama City to Lisbon, returning Sun, May 24, priced at $797 found 1 hour ago
KLM
Sat, Jan 31 - Mon, Feb 16
PTY
Panama City
LIS
Lisbon
$802 Roundtrip, found 6 days ago
$802
Roundtrip
found 6 days ago
Select KLM flight, departing Sat, Jan 31 from Panama City to Lisbon, returning Mon, Feb 16, priced at $802 found 6 days ago

Find the cheapest month to fly from Panama City (PTY) to Lisbon (LIS)

March is typically the cheapest month to fly

From $692 - $1,231 per traveler.

Alternative airports near Lisbon

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Humberto Delgado LIS. Cheapest option available. Flights from $890
LIS
Humberto Delgado
Cheapest
Flights from $890

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS) cost?
Get a cheap one-way flight from $540 or cheap return flight from $738 from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)?
December is the cheapest month to fly from PTY to LIS. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest PTY to LIS flight.
How many flights per day from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)?
There aren't any daily direct flights from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds in no time at all.
What day of the week has the most flights from PTY to LIS?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can change based on a range of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)?
Choose a flight from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS) last-minute?
Last-minute bookings from PTY to LIS are usually more expensive. For the lowest prices, start looking for flights ahead of time. That said, if you're flexible with your travel plans, it's possible to land a cheap fare just before your departure.
Is it cheaper to book a PTY to LIS flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to LIS flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place takes the hassle out of travel planning. Simply pick your flights and choose from our wide range of stays, then tailor your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Humberto Delgado Airport (LIS)?
In most instances, you're able to cancel or reschedule your PTY to LIS flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you'd like further details, visit our Customer Service portal.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Humberto Delgado
Airlines serving
Air Europa, Air France, American Airlines, Delta, Iberia, KLM, Turkish Airlines, United
Roundtrip price
$737
Distance
4765 mi

Book with confidence

Panama City to Lisbon Flights

The cheapest times to fly from Panama City to Lisbon

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Lisbon are during the month of December. You can find some of the cheapest flights from Panama City to Lisbon with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Lisbon

Sunday is one of the best days to book for cheap flights from Panama City to Lisbon: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Lisbon

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Lisbon in 2025. You can also book with separate airlines for your outbound and return journeys, from $540 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Lisbon flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Lisbon airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to Lisbon Flights

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*Available to One Key members.