$662 Cheap Flights from Santander (SDR) to Panama City (PTY)

View $662 flight on Fri, Jun 26, 2026Opens in a new window

Popular airlines from Santander (SDR) to Tocumen Intl. Airport (PTY)

Cheap Flights from Santander to Panama City (SDR-PTY)

Prices were available within the past 7 days and start at $662 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Flights from Santander (SDR) to Panama City (PTY)
Origin airport
Santander
Destination airport
Tocumen Intl.
Distance
5065 mi

Santander to Panama City Flights

The cheapest times to fly from Santander to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santander to Panama City are during the month of . You can find some of the cheapest flights from Santander to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santander to Panama City

Sunday is one of the best days to book for cheap flights from Santander to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santander to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santander to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $662 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santander to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santander to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Santander Airport (SDR) to Tocumen Intl. Airport (PTY) cost?
Grab a cheap one-way flight from $662 or cheap return flight from Santander Airport (SDR) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Santander Airport (SDR) to Tocumen Intl. Airport (PTY)?
Planning your trip for can help you save, as it's the cheapest month for flights between SDR and PTY. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Santander Airport (SDR) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest SDR to PTY flight.
How many flights per day from Santander Airport (SDR) to Tocumen Intl. Airport (PTY)?
You'll need to hop on a flight with a layover when traveling from Santander Airport (SDR) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from SDR to PTY?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change based on various factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Santander Airport (SDR) to Tocumen Intl. Airport (PTY)?
Select a flight from Santander Airport (SDR) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the likelihood of delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Santander Airport (SDR) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from SDR to PTY right before your journey is typically more expensive. However, if there's some wiggle room with your travel times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a SDR to PTY flight and hotel package?
You can save money by securing a SDR to PTY flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After choosing your preferred flights and accommodations, consider other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Santander Airport (SDR) to Tocumen Intl. Airport (PTY)?
In most instances, you can cancel or reschedule your SDR to PTY flight. However, additional fees may apply, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you want more information, visit our Customer Service portal.

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*Available to One Key members.