$226 Cheap Flights from Syracuse (SYR) to Panama City (PTY)

View $226 flight on Mon, Mar 9, 2026Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY)

Cheap Flights from Syracuse to Panama City (SYR-PTY)

Prices were available within the past 7 days and start at $226 for one-way flights and $518 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Feb 23 - Wed, Mar 4
SYR
Syracuse
PTY
Panama City
$518 Roundtrip, found 8 hours ago
$518
Roundtrip
found 8 hours ago
Select Delta flight, departing Mon, Feb 23 from Syracuse to Panama City, returning Wed, Mar 4, priced at $518 found 8 hours ago
United
Wed, Apr 8 - Tue, Apr 14
SYR
Syracuse
PTY
Panama City
$518 Roundtrip, found 8 hours ago
$518
Roundtrip
found 8 hours ago
Select United flight, departing Wed, Apr 8 from Syracuse to Panama City, returning Tue, Apr 14, priced at $518 found 8 hours ago
American Airlines
Fri, Jan 30 - Mon, Feb 2
SYR
Syracuse
PTY
Panama City
$522 Roundtrip, found 21 hours ago
$522
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Fri, Jan 30 from Syracuse to Panama City, returning Mon, Feb 2, priced at $522 found 21 hours ago
United
Thu, Apr 2 - Mon, Apr 13
SYR
Syracuse
PTY
Panama City
$524 Roundtrip, found 12 hours ago
$524
Roundtrip
found 12 hours ago
Select United flight, departing Thu, Apr 2 from Syracuse to Panama City, returning Mon, Apr 13, priced at $524 found 12 hours ago
Delta
Mon, Jan 19 - Tue, Feb 3
SYR
Syracuse
PTY
Panama City
$527 Roundtrip, found 1 day ago
$527
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Jan 19 from Syracuse to Panama City, returning Tue, Feb 3, priced at $527 found 1 day ago
United
Thu, Apr 2 - Wed, Apr 8
SYR
Syracuse
PTY
Panama City
$529 Roundtrip, found 12 hours ago
$529
Roundtrip
found 12 hours ago
Select United flight, departing Thu, Apr 2 from Syracuse to Panama City, returning Wed, Apr 8, priced at $529 found 12 hours ago
American Airlines
Sat, Mar 14 - Sat, Mar 21
SYR
Syracuse
PTY
Panama City
$529 Roundtrip, found 1 day ago
$529
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 14 from Syracuse to Panama City, returning Sat, Mar 21, priced at $529 found 1 day ago
American Airlines
Thu, Oct 1 - Tue, Oct 6
SYR
Syracuse
PTY
Panama City
$531 Roundtrip, found 1 day ago
$531
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 1 from Syracuse to Panama City, returning Tue, Oct 6, priced at $531 found 1 day ago
Delta
Sat, Feb 28 - Wed, Mar 11
SYR
Syracuse
PTY
Panama City
$532 Roundtrip, found 2 days ago
$532
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Feb 28 from Syracuse to Panama City, returning Wed, Mar 11, priced at $532 found 2 days ago
avianca
Thu, Oct 15 - Mon, Oct 19
SYR
Syracuse
PTY
Panama City
$1,816 Roundtrip, found 4 days ago
$1,816
Roundtrip
found 4 days ago
Select avianca flight, departing Thu, Oct 15 from Syracuse to Panama City, returning Mon, Oct 19, priced at $1,816 found 4 days ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $897
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $897

Frequently asked questions

How much does a flight from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY) cost?
Lock in a cheap one-way flight from $226 or cheap return flight from $518 from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from SYR to PTY is February, when there's less demand. Off-peak season is often when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest SYR to PTY flight.
How many flights per day from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY)?
Nonstop flights from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from SYR to PTY?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY)?
Select a flight from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the likelihood of delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from SYR to PTY are typically more expensive. To lock in the best prices, start looking for flights early. That being said, if you're flexible with your travel dates, it's possible to score a cheap ticket right before you leave.
Is it cheaper to book a SYR to PTY flight and hotel package?
You'll generally save money by securing a SYR to PTY flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After choosing your preferred accommodations and flights, consider adding extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Hancock Intl. Airport (SYR) to Tocumen Intl. Airport (PTY)?
If you reserved your SYR to PTY flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

Travel information

Origin airport
Hancock Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$517
Distance
2360 mi

Book with confidence

Syracuse to Panama City Flights

The cheapest times to fly from Syracuse to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to Panama City are during the month of February. You can find some of the cheapest flights from Syracuse to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to Panama City

Sunday is one of the best days to book for cheap flights from Syracuse to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $226 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Syracuse to Panama City Flights

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*Available to One Key members.