$282 Cheap Flights from Knoxville (TYS) to Santo Domingo (SDQ)

View $282 flight on Tue, Feb 10, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from Knoxville to Santo Domingo (TYS-SDQ)

Prices were available within the past 7 days and start at $282 for one-way flights and $468 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 26 - Wed, Dec 3
TYS
Knoxville
SDQ
Santo Domingo
$468 Roundtrip, found 19 hours ago
$468
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Nov 26 from Knoxville to Santo Domingo, returning Wed, Dec 3, priced at $468 found 19 hours ago
Delta
Sun, Jan 25 - Tue, Feb 3
TYS
Knoxville
SDQ
Santo Domingo
$472 Roundtrip, found 14 hours ago
$472
Roundtrip
found 14 hours ago
Select Delta flight, departing Sun, Jan 25 from Knoxville to Santo Domingo, returning Tue, Feb 3, priced at $472 found 14 hours ago
American Airlines
Wed, Nov 26 - Wed, Dec 3
TYS
Knoxville
SDQ
Santo Domingo
$478 Roundtrip, found 19 hours ago
$478
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Nov 26 from Knoxville to Santo Domingo, returning Wed, Dec 3, priced at $478 found 19 hours ago
American Airlines
Mon, Dec 29 - Tue, Jan 13
TYS
Knoxville
SDQ
Santo Domingo
$480 Roundtrip, found 2 days ago
$480
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Dec 29 from Knoxville to Santo Domingo, returning Tue, Jan 13, priced at $480 found 2 days ago
American Airlines
Tue, Dec 30 - Tue, Jan 13
TYS
Knoxville
SDQ
Santo Domingo
$480 Roundtrip, found 7 hours ago
$480
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Dec 30 from Knoxville to Santo Domingo, returning Tue, Jan 13, priced at $480 found 7 hours ago
American Airlines
Tue, Dec 30 - Tue, Jan 13
TYS
Knoxville
SDQ
Santo Domingo
$482 Roundtrip, found 7 hours ago
$482
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Dec 30 from Knoxville to Santo Domingo, returning Tue, Jan 13, priced at $482 found 7 hours ago
American Airlines
Fri, Jan 9 - Fri, Jan 16
TYS
Knoxville
SDQ
Santo Domingo
$487 Roundtrip, found 13 hours ago
$487
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, Jan 9 from Knoxville to Santo Domingo, returning Fri, Jan 16, priced at $487 found 13 hours ago
American Airlines
Tue, Feb 10 - Sun, Feb 15
TYS
Knoxville
SDQ
Santo Domingo
$487 Roundtrip, found 1 day ago
$487
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from Knoxville to Santo Domingo, returning Sun, Feb 15, priced at $487 found 1 day ago
American Airlines
Fri, Feb 6 - Fri, Feb 13
TYS
Knoxville
SDQ
Santo Domingo
$488 Roundtrip, found 1 day ago
$488
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Feb 6 from Knoxville to Santo Domingo, returning Fri, Feb 13, priced at $488 found 1 day ago
United
Tue, Jan 20 - Wed, Jan 28
TYS
Knoxville
SDQ
Santo Domingo
$2,773 Roundtrip, found 5 days ago
$2,773
Roundtrip
found 5 days ago
Select United flight, departing Tue, Jan 20 from Knoxville to Santo Domingo, returning Wed, Jan 28, priced at $2,773 found 5 days ago

Find the cheapest month to fly from Knoxville (TYS) to Santo Domingo (SDQ)

February is typically the cheapest month to fly

From $463 - $584 per traveler.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ) cost?
Secure a cheap one-way flight from $282 or cheap return flight from $468 from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ)?
Traveling in November can help you save, as it's the cheapest month for flights between TYS and SDQ. You'll typically find the lowest fares during off-peak months.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ)?
To find the cheapest airline that'll fly you from TYS to SDQ, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ)?
You'll need to catch a flight with a layover when traveling from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from TYS to SDQ?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ)?
Select a flight from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ) that leaves before 3 PM to reduce the risk of cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ) last-minute?
Booking your plane ticket from TYS to SDQ just before your trip is generally more expensive. But if you're flexible with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a TYS to SDQ flight and hotel package?
Compared with arranging flights and hotels separately, booking a TYS to SDQ flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place will take the hassle out of travel planning. Simply secure your flights and choose from our wide range of stays, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Las Americas Intl. Airport (SDQ)?
If you reserved your TYS to SDQ flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

Travel information

Origin airport
McGhee Tyson
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$467
Distance
1484 mi

Book with confidence

Knoxville to Santo Domingo Flights

The cheapest times to fly from Knoxville to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Santo Domingo are during the month of November. You can find some of the cheapest flights from Knoxville to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Santo Domingo

Sunday is one of the best days to book for cheap flights from Knoxville to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $282 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Santo Domingo Flights

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*Available to One Key members.