$349 Cheap Flights from Quito (UIO) to Santiago (STI)

View $349 flight on Thu, Jan 29, 2026Opens in a new window

Popular airlines from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI)

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Cheap Flights from Quito to Santiago (UIO-STI)

Prices were available within the past 7 days and start at $349 for one-way flights and $756 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Feb 2 - Thu, Feb 5
UIO
Quito
STI
Santiago de los Caballeros
$756 Roundtrip, found 5 days ago
$756
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Feb 2 from Quito to Santiago de los Caballeros, returning Thu, Feb 5, priced at $756 found 5 days ago
Copa
Thu, Jan 22 - Sun, Jan 25
UIO
Quito
STI
Santiago de los Caballeros
$807 Roundtrip, found 5 days ago
$807
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Jan 22 from Quito to Santiago de los Caballeros, returning Sun, Jan 25, priced at $807 found 5 days ago
Copa
Thu, Jan 22 - Sun, Jan 25
UIO
Quito
STI
Santiago de los Caballeros
$873 Roundtrip, found 5 days ago
$873
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Jan 22 from Quito to Santiago de los Caballeros, returning Sun, Jan 25, priced at $873 found 5 days ago
Copa
Mon, Feb 2 - Thu, Feb 5
UIO
Quito
STI
Santiago de los Caballeros
$888 Roundtrip, found 5 days ago
$888
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Feb 2 from Quito to Santiago de los Caballeros, returning Thu, Feb 5, priced at $888 found 5 days ago
United
Tue, Apr 21 - Sat, Apr 25
UIO
Quito
STI
Santiago de los Caballeros
$923 Roundtrip, found 5 days ago
$923
Roundtrip
found 5 days ago
Select United flight, departing Tue, Apr 21 from Quito to Santiago de los Caballeros, returning Sat, Apr 25, priced at $923 found 5 days ago
United
Tue, Apr 21 - Sat, Apr 25
UIO
Quito
STI
Santiago de los Caballeros
$937 Roundtrip, found 5 days ago
$937
Roundtrip
found 5 days ago
Select United flight, departing Tue, Apr 21 from Quito to Santiago de los Caballeros, returning Sat, Apr 25, priced at $937 found 5 days ago
United
Tue, Apr 21 - Sat, Apr 25
UIO
Quito
STI
Santiago de los Caballeros
$983 Roundtrip, found 5 days ago
$983
Roundtrip
found 5 days ago
Select United flight, departing Tue, Apr 21 from Quito to Santiago de los Caballeros, returning Sat, Apr 25, priced at $983 found 5 days ago
avianca
Tue, Jan 13 - Wed, Jan 28
UIO
Quito
STI
Santiago de los Caballeros
$1,144 Roundtrip, found 4 hours ago
$1,144
Roundtrip
found 4 hours ago
Select avianca flight, departing Tue, Jan 13 from Quito to Santiago de los Caballeros, returning Wed, Jan 28, priced at $1,144 found 4 hours ago
American Airlines
Mon, Jan 12 - Thu, Jan 22
UIO
Quito
STI
Santiago de los Caballeros
$1,229 Roundtrip, found 4 hours ago
$1,229
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Mon, Jan 12 from Quito to Santiago de los Caballeros, returning Thu, Jan 22, priced at $1,229 found 4 hours ago
Delta
Sat, Nov 29 - Sat, Dec 6
UIO
Quito
STI
Santiago de los Caballeros
$1,285 Roundtrip, found 19 hours ago
$1,285
Roundtrip
found 19 hours ago
Select Delta flight, departing Sat, Nov 29 from Quito to Santiago de los Caballeros, returning Sat, Dec 6, priced at $1,285 found 19 hours ago

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Alternative airports near Santiago de los Caballeros

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Gregorio Luperon Intl. POP. Cheapest option available. Average driving time to city center is 59 minutes. Flights from $1,409
POP
Gregorio Luperon Intl.
Cheapest
Average driving time to city center59 min
Flights from $1,409
Flights from Quito (UIO) to Santiago (STI)
Origin airport
Mariscal Sucre Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$755
Distance
1447 mi

Quito to Santiago Flights

The cheapest times to fly from Quito to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Quito to Santiago are during the month of February. You can find some of the cheapest flights from Quito to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Quito to Santiago

Sunday is one of the best days to book for cheap flights from Quito to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Quito to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Quito to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $349 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Quito to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Quito to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI) cost?
Snag a cheap one-way flight from $349 or cheap return flight from $756 from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI)?
February is the least expensive month to fly from UIO to STI. Traveling outside of peak seasons is often the key to better flight prices.
What is the cheapest airline that flies from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from UIO to STI. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI)?
Direct flights from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from UIO to STI?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary based on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI)?
To touch down at Cibao Intl. Airport (STI) without delays, select a flight that leaves from Mariscal Sucre Intl. Airport (UIO) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI) last-minute?
Last-minute fares from UIO to STI are usually more expensive. For the best prices, start looking for flights as soon as possible. That said, if your travel plans are flexible, you may score a cheap fare right before your journey.
Is it cheaper to book an UIO to STI flight and hotel package?
Compared with arranging flights and hotels separately, booking an UIO to STI flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one convenient place takes the hassle out of travel planning. Just secure your flights and select from our wide range of hotels, then customize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Mariscal Sucre Intl. Airport (UIO) to Cibao Intl. Airport (STI)?
If you reserved your UIO to STI flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you'd like more information.

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