$217 Cheap American Airlines flights Des Moines (DSM) to Charlotte (CLT)

Set the “Price (lowest to highest)” filter on Expedia to find cheap American Airlines return flights from $283 from DSM to CLT. Affordable one-way tickets from $217 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for return or one-way flights to Charlotte in January or February. You could find lower fares with American Airlines during these quieter months.

Start searching one to three months ahead of your travel date to score cheap fares on American Airlines flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing spot on, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

American Airlines operates direct flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT), with 14 weekly departures. Just apply the “Nonstop” and “Airline” filters during your search on Expedia to see all direct American Airlines flights to CLT.

Take off from Des Moines Intl. Airport (DSM) for Charlotte-Douglas Intl. Airport (CLT) on a nonstop American Airlines flight, and you’ll be in the air for about 2h 20m.

American Airlines has the most flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) on Thursday. With up to 2 daily departures, you’ll get the most flexibility and choice on this day.

Taking off from DSM at 6:17AM UTC-6, the earliest American Airlines flight to CLT lands at 9:52AM UTC-5. Flying early means you’ll be less likely to encounter delays.* Prefer a later start? The last American Airlines flight from DSM to CLT departs at 2:06PM UTC-6 and touches down at 5:26PM UTC-5.*Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Jump on an American Airlines flight from Des Moines Intl. Airport (DSM) to Charlotte, and you’ll most likely arrive at Charlotte-Douglas Intl. Airport (CLT). This is the airline’s main hub in this city.

American Airlines typically uses Airbus A319 planes for flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). This carrier also operates the Airbus A320 on this route. Remember that aircraft type can change due to operational reasons, so the plane you board might be different when you travel.

Depending on the type of ticket you purchased, a fee typically applies if you cancel or reschedule your flight more than 24 hours after it’s been confirmed. To find flexible fares, select our “No cancel fee” or “Changes included” filter when looking for flights. To learn more about modifying or canceling your reservation, go to “Trips,” select your flight and click on “Manage Booking.”