$1,539 Cheap American Airlines flights Des Moines (DSM) to Pisa (PSA)

You can find budget-friendly return American Airlines flights from $2,525 from DSM to PSA by filtering your results from "Price (lowest to highest)" on Expedia. Or look for bargains from $1,539 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Scoring the best American Airlines deals from DSM to PSA is typically all about timing. You can save 17% on international flights when you book 18 to 29 days before takeoff instead of four to five months ahead. As an added bonus, you can pocket 17% on average by buying your tickets on a Sunday rather than a Friday, which is often the most expensive day to book.* It's a good idea to start searching for flights about one month before you want to travel.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to see the earliest flights from DSM to PSA. Jetting off early means you're 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.