$295 Cheap American Airlines flights Myrtle Beach (MYR) to San Luis Obispo (SBP)

Landing cheap one-way American Airlines flights from MYR to SBP from $295 on Expedia is a breeze — just filter by "Price (lowest to highest)." Or check out our affordable return fares from $419 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months ahead of your departure date to find cheap fares on American Airlines flights from Myrtle Beach Intl. Airport (MYR) to San Luis Obispo County Regional Airport (SBP). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Early Morning" and "Morning" to see the earliest departures from MYR to SBP. Setting off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.