$161 Cheap American Airlines flights Tampa (TPA) to Santiago (STI)

Grab affordable return American Airlines flights from $323 from TPA to STI by sorting your results from "Price (lowest to highest)" on Expedia. Or search for bargains from $161 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To grab affordable flights from TPA to STI with American Airlines, start your search about one month before your intended departure. You can save 17% when you lock in your international tickets 18 to 29 days ahead instead of booking four to five months in advance. Another tip? Booking on Sunday offers average savings of 17% compared to Friday (the most expensive day).**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from TPA to STI with American Airlines, filter your search by "Morning" and "Early Morning." Booking an early flight generally means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.