$197 Cheap Delta flights Des Moines (DSM) to Charlotte (CLT)

Finding cheap one-way Delta Air Lines flights from DSM to CLT from $197 on Expedia is a breeze — just filter by “Price (lowest to highest).” Alternatively, check out our affordable return fares from $307 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the least expensive months to jet away to Charlotte with Delta Air Lines. You could also find excellent prices on one-way and round-trip fares in February.

Look for affordable Delta Air Lines flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and journey, the best day to book a domestic flight is usually Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use the “Nonstop” filter when browsing for direct Delta Air Lines flights from DSM to CLT. You can also compare other airlines offering the same nonstop route.

Find Delta Air Lines’s earliest flights from DSM to CLT by checking the “Morning” and “Early Morning” filters. Not only will you get to your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Delta Air Lines flights from Des Moines Intl. Airport (DSM) to Charlotte touch down at Charlotte-Douglas Intl. Airport (CLT). This is the main gateway to this destination.

Delta Air Lines makes flying from DSM to CLT more comfortable with an excellent in-flight experience and a rewarding loyalty program. You could even start collecting points with Delta SkyMiles. Don’t forget to join our free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future travel.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Depending on the ticket type you purchased, a fee is typically charged if you cancel or reschedule your booking more than 24 hours after confirmation. To find plane tickets with more flexibility, select our “No cancel fee” or “Changes included” filter when you look for flights. For more details on canceling or modifying your reservation, visit “Trips,” select your flight and click on “Manage Booking.”