$109 Cheap Delta flights Knoxville (TYS) to San Antonio (SAT)

Scoring cheap one-way Delta Air Lines flights from TYS to SAT from $109 on Expedia couldn't be simpler — just filter by "Price (lowest to highest)." Or check out our affordable return fares from $194 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable Delta Air Lines flights from McGhee Tyson Airport (TYS) to San Antonio Intl. Airport (SAT) one to three months prior to your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and itinerary, the ideal day to book a domestic flight is generally Sunday and the most expensive day tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from TYS to SAT with Delta Air Lines, filter your results by "Early Morning" and "Morning." Booking an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Offering a rewarding loyalty program and an excellent in-flight experience, Delta Air Lines is the leading choice for many passengers flying from TYS to SAT. Plus, if you're a Delta SkyMiles and One Key™ member booking through Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be put toward future getaways.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.