$152 Cheap Flights from Charleston (CHS) to Panama City (PTY)

View $152 flight on Wed, Feb 25, 2026Opens in a new window

Popular airlines from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Charleston to Panama City (CHS-PTY)

Prices were available within the past 7 days and start at $152 for one-way flights and $370 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Dec 9 - Tue, Dec 23
CHS
Charleston
PTY
Panama City
$370 Roundtrip, found 1 day ago
$370
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Dec 9 from Charleston to Panama City, returning Tue, Dec 23, priced at $370 found 1 day ago
United
Tue, Mar 31 - Mon, Apr 13
CHS
Charleston
PTY
Panama City
$370 Roundtrip, found 9 hours ago
$370
Roundtrip
found 9 hours ago
Select United flight, departing Tue, Mar 31 from Charleston to Panama City, returning Mon, Apr 13, priced at $370 found 9 hours ago
American Airlines
Thu, May 14 - Thu, May 21
CHS
Charleston
PTY
Panama City
$374 Roundtrip, found 2 days ago
$374
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, May 14 from Charleston to Panama City, returning Thu, May 21, priced at $374 found 2 days ago
Delta
Mon, Apr 13 - Tue, Apr 21
CHS
Charleston
PTY
Panama City
$376 Roundtrip, found 20 hours ago
$376
Roundtrip
found 20 hours ago
Select Delta flight, departing Mon, Apr 13 from Charleston to Panama City, returning Tue, Apr 21, priced at $376 found 20 hours ago
American Airlines
Wed, Apr 1 - Wed, Apr 8
CHS
Charleston
PTY
Panama City
$377 Roundtrip, found 2 hours ago
$377
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Charleston to Panama City, returning Wed, Apr 8, priced at $377 found 2 hours ago
American Airlines
Fri, Jan 30 - Mon, Feb 2
CHS
Charleston
PTY
Panama City
$380 Roundtrip, found 2 days ago
$380
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jan 30 from Charleston to Panama City, returning Mon, Feb 2, priced at $380 found 2 days ago
American Airlines
Tue, Dec 16 - Fri, Dec 19
CHS
Charleston
PTY
Panama City
$382 Roundtrip, found 6 days ago
$382
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 16 from Charleston to Panama City, returning Fri, Dec 19, priced at $382 found 6 days ago
Delta
Tue, Dec 9 - Tue, Dec 23
CHS
Charleston
PTY
Panama City
$382 Roundtrip, found 1 day ago
$382
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Dec 9 from Charleston to Panama City, returning Tue, Dec 23, priced at $382 found 1 day ago
United
Thu, May 14 - Thu, May 21
CHS
Charleston
PTY
Panama City
$384 Roundtrip, found 2 days ago
$384
Roundtrip
found 2 days ago
Select United flight, departing Thu, May 14 from Charleston to Panama City, returning Thu, May 21, priced at $384 found 2 days ago
Copa
Mon, Dec 15 - Mon, Jan 12
CHS
Charleston
PTY
Panama City
$1,166 Roundtrip, just found
$1,166
Roundtrip
just found
Select Copa flight, departing Mon, Dec 15 from Charleston to Panama City, returning Mon, Jan 12, priced at $1,166 just found

Find the cheapest month to fly from Charleston (CHS) to Panama City (PTY)

October is typically the cheapest month to fly

From $313 - $986 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $434
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $434

Frequently asked questions

How much does a flight from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) cost?
Snag a cheap one-way flight from $152 or cheap return flight from $370 from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
December is the most affordable month to fly from CHS to PTY. Planning your trip for the off-season is often the key to finding better fares.
What is the cheapest airline that flies from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest CHS to PTY flight.
How many flights per day from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
Direct flights from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from CHS to PTY?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
Select a flight from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) that takes off before 3 PM to reduce the likelihood of delays. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from CHS to PTY just before your trip is generally more expensive. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a CHS to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a CHS to PTY flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Simply secure your flights and select from our extensive range of stays, then personalize your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
In most cases, you can cancel or reschedule your CHS to PTY flight. However, there may be additional fees, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you'd like more details, go to our Customer Service portal.

Travel information

Origin airport
Charleston Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$369
Distance
1646 mi

Book with confidence

Charleston to Panama City Flights

The cheapest times to fly from Charleston to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charleston to Panama City are during the month of December. You can find some of the cheapest flights from Charleston to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Charleston to Panama City

Sunday is one of the best days to book for cheap flights from Charleston to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Charleston to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charleston to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $152 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charleston to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charleston to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Charleston to Panama City Flights

Explore a world of travel with Expedia

*Available to One Key members.