$1,037 Cheap Flights from Denver (DEN) to São Tomé Island (TMS)

View $1,037 flight on Sat, Nov 29, 2025Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to São Tomé Island (TMS-São Tomé Intl.)

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Cheap Flights from Denver to São Tomé Island (DEN-TMS)

Prices were available within the past 7 days and start at $1,037 for one-way flights and $1,704 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,704 Roundtrip, found 6 days ago
$1,704
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,704 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,717 Roundtrip, found 6 days ago
$1,717
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,717 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,723 Roundtrip, found 6 days ago
$1,723
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,723 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,724 Roundtrip, found 6 days ago
$1,724
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,724 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,726 Roundtrip, found 6 days ago
$1,726
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,726 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,729 Roundtrip, found 6 days ago
$1,729
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,729 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,733 Roundtrip, found 6 days ago
$1,733
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,733 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,735 Roundtrip, found 6 days ago
$1,735
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,735 found 6 days ago
Lufthansa
Sun, Apr 26 - Sun, May 3
DEN
Denver
TMS
São Tomé Island
$1,737 Roundtrip, found 6 days ago
$1,737
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Apr 26 from Denver to São Tomé Island, returning Sun, May 3, priced at $1,737 found 6 days ago
Brussels Airlines
Sat, Nov 29 - Wed, Dec 3
DEN
Denver
TMS
São Tomé Island
$1,902 Roundtrip, found 1 day ago
$1,902
Roundtrip
found 1 day ago
Select Brussels Airlines flight, departing Sat, Nov 29 from Denver to São Tomé Island, returning Wed, Dec 3, priced at $1,902 found 1 day ago

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS) cost?
Snag a cheap one-way flight from $1,037 or cheap return flight from $1,704 from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
April is the least expensive month to fly from DEN to TMS. Traveling outside of peak seasons is often the key to scoring lower fares.
What is the cheapest airline that flies from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DEN to TMS flight.
How many flights per day from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
You'll need to book a flight with a layover if you're traveling from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from DEN to TMS?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on various factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
To land at Sao Tome Intl. Airport (TMS) on time, opt for a flight that leaves Denver Intl. Airport (DEN) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS) last-minute?
Last-minute fares from DEN to TMS are generally more expensive. For the lowest prices, start searching for flights well ahead of time. That said, if you can play around with your travel dates, you may land a cheap fare just before your departure.
Is it cheaper to book a DEN to TMS flight and hotel package?
Compared with arranging flights and hotels separately, booking a DEN to TMS flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of stays, then personalize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
It's generally possible to cancel or reschedule your DEN to TMS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Denver Intl.
Destination airport
São Tomé Intl.
Roundtrip price
$1,704
Distance
7324 mi

Book with confidence

Denver to São Tomé Island Flights

The cheapest times to fly from Denver to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to São Tomé Island are during the month of April. You can find some of the cheapest flights from Denver to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to São Tomé Island

Sunday is one of the best days to book for cheap flights from Denver to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,037 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Denver to São Tomé Island Flights
*Available to One Key members.