$135 Cheap Flights from Des Moines (DSM) to Greenville (GSP)
Popular airlines from Des Moines International Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)
American AirlinesAmerican Airlines
DeltaDelta
UnitedUnited
Southwest AirlinesSouthwest Airlines
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Cheap Flights from Des Moines to Greenville (DSM-GSP)
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Des Moines (DSM) to Greenville (GSP) at a glance
Discover a range of options for flights from Des Moines (DSM) to Greenville (GSP) on this domestic short-haul route. Whether you prefer full-service airlines or budget-friendly carriers, you can easily compare choices to find the best itinerary that suits your budget and schedule. Get ready to explore the iconic sights and neighborhoods of Greenville as you check out the essential details for your journey from Des Moines International Airport to Greenville-Spartanburg International Airport.
- Fastest flight duration: around 3h 30m in-flight, plus roughly 1h 15m layover with one stop
- Route distance: roughly 800 miles (1,290 km)
- Flights per week: around 9 departures on average
- Typical fares (one-way): economy tickets often range from $120–$390, depending on seasonality and how far ahead you book
Flights from Des Moines International Airport (DSM) to Greenville-Spartanburg International Airport (GSP)
According to recent traveler bookings, here are the top airlines favored for flights from Des Moines to Greenville, especially for those opting for one-stop service. Common layover spots include Charlotte-Douglas International Airport (CLT) with around a 1 hour and 15 minute layover, Hartsfield-Jackson Atlanta International Airport (ATL) also about 1 hour and 15 minutes, and O'Hare International Airport (ORD) with a 1-hour layover. This allows you to easily compare prices, total travel times, and cabin classes to secure the best itinerary.
- American Airlines: As a comprehensive service provider, American Airlines offers one-stop flights with one-way prices generally between $120 and $400. This airline accounts for about 54% of departures on this route, featuring an in-flight duration of 3 hours and 30 minutes, with a total travel time of around 4 hours and 45 minutes, including layover.
- Delta: Delta operates as a full-service airline providing one-stop service, with one-way fares usually ranging from $120 to $380. It comprises roughly 31% of the departures on this route, with an in-flight time of 3 hours and 30 minutes, and a total journey time of about 4 hours and 45 minutes, factoring in a layover.
- United: United Airlines, another full-service carrier, features one-stop flights with one-way fares typically priced between $150 and $385. This airline accounts for approximately 15% of the departures on this route, maintaining an in-flight time of 3 hours and 30 minutes, and an overall travel duration of around 4 hours and 45 minutes, including layover.
Best time to fly from Des Moines (DSM) to Greenville (GSP)
The most popular months for travelers flying from Des Moines to Greenville are July, August, and November, when peak temperatures in Greenville reach up to 79.5°F in July. If you prefer quieter travel, consider September, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 72.3°F. For better deals, August usually offers the lowest average one-way fare around $182. Flight availability peaks in April, May, August, and November, with approximately 11 flights per week, making it easier to find convenient departure times. January and February have the fewest flights, with approximately 7 flights per week.
- Cheapest time to fly: August usually offers good deals with average one-way fare around $182, roughly 20% cheaper than the yearly average.
- More budget-friendly months to fly: October and July typically offer average one-way fares roughly ranging from $188 to $199.
- Most flight options: April, May, August, and November have the highest number of flights from Des Moines to Greenville, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
| Month | Temperature | Demand | Weekly Flights | Average one-way Fare |
| January | 41.4°F (5.2°C) | Average | 7 | $262 |
| February | 45.3°F (7.4°C) | Moderately Low | 7 | $262 |
| March | 51.8°F (11.0°C) | Average | 9 | $257 |
| April | 59.9°F (15.5°C) | Average | 11 | $236 |
| May | 68.4°F (20.2°C) | Average | 11 | $230 |
| June | 76.1°F (24.5°C) | Average | 8 | $217 |
| July | 79.5°F (26.4°C) | Moderately High | 10 | $199 |
| August | 77.5°F (25.3°C) | Moderately High | 11 | $182 |
| September | 72.3°F (22.4°C) | Moderately Low | 10 | $202 |
| October | 61.9°F (16.6°C) | Average | 8 | $188 |
| November | 51.1°F (10.6°C) | Moderately High | 11 | $203 |
| December | 45.3°F (7.4°C) | Moderately Low | 8 | $311 |
*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.
Alternative routes from Des Moines (DSM) to Greenville (GSP)
- Des Moines to Greenville (DSM-GDC): Donaldson Center Airport (GDC) is located approximately 13 miles from Greenville-Spartanburg International Airport (GSP).
- Ottumwa Regional Airport to Greenville (OTM-GSP): Ottumwa Regional Airport (OTM) lies around 69 miles from Des Moines International Airport (DSM).
- Fort Dodge to Greenville (FOD-GSP): Fort Dodge Regional Airport (FOD) is situated roughly 76 miles from Des Moines International Airport (DSM).
How to find the best prices for flights from Des Moines (DSM) to Greenville (GSP)
Getting some of the best deals on flights from Des Moines to Greenville is all about timing and flexibility. Here are some key tips to help you save:
- Best times to book and fly: cheaper fares are generally available when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Afternoon departures from 12 PM to 6 PM usually offer lower prices, while morning flights from 5 AM to 12 PM are the most popular. Additionally, flying on Wednesday provides both cheaper fares and is the favored travel day.
- Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
- Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Greenville hotel and flight deals.
- Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
- Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
- Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.
*Members only. Savings vary and are not available on all bundles. Select hotels.
Arriving at Greenville-Spartanburg International Airport from Des Moines International Airport
Greenville welcomes travelers from Des Moines with a range of transport options based on price, convenience, and proximity. Greenville city center is approximately a 20-minute drive (covering about 16 miles) from Greenville-Spartanburg International Airport, depending on traffic. Here's how to reach Greenville efficiently:
- Hotel transfer: Transfers offer a convenient way to reach your hotel in Greenville, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
- Car rental: Renting a car from Greenville-Spartanburg International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Greenville-Spartanburg International Airport on Expedia.
- Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
Des Moines to Greenville Flights
The cheapest times to fly from Des Moines to Greenville
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Greenville are during the month of November. You can find some of the cheapest flights from Des Moines to Greenville with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Des Moines to Greenville
Sunday is one of the best days to book for cheap flights from Des Moines to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Des Moines to Greenville
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from $135 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently Asked Questions
How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) cost?
You can find cheap one-way flights from $135 and cheap return flights $269 Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) with Expedia. One-way flights typically cost between $155 and $608, and return flights often range between $309 and $1053. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) ticket fares go up or down.
*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
October is the cheapest month to fly from Des Moines (DSM) to Greenville (GSP), with average round-trip fares around $293. This price is about 25% lower than the average throughout the year, as October is typically a quieter travel month. Other economical months include August and September.
*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Enter DSM to GSP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Southwest Airlines is one of the cheapest airlines offering connecting flights from Des Moines Intl. (DSM) to Greenville-Spartanburg Intl. (GSP), with round-trip tickets starting from around $601. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The best time to fly from Des Moines, IA (DSM) to Greenville, SC (GSP) is typically in October or September. During these months, you can expect average prices around $293 for a return flight, making it a budget-friendly option. October and September are ideal because they balance lower travel demand with pleasant weather, allowing you to enjoy your trip without the crowds.
*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The earliest flight from Des Moines International Airport (DSM) to Greenville-Spartanburg International Airport (GSP) usually departs at around 5:00 AM, operated by American Airlines. This is a seasonal service active in March, and an early departure can give you a head start on your day in Greenville. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The most popular departure times for flights from Des Moines, IA (DSM) to Greenville, SC (GSP) are in the early morning, from 6am to 9am. This accounts for around 29% of total traffic. Many major carriers, including American Airlines, Delta Air Lines, and United Airlines, offer flights during this window. Many travelers prefer this time as it allows for a smooth start to their day.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
A flight from DSM to GSP with a layover takes around 6 hours 30 minutes, with the route covering approximately 771 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
First class seats are offered on the DSM to GSP route. First class cabins are available on:
- Delta Air Lines
- American Airlines
- United Airlines
How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.
*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Greenville from Des Moines Intl. (DSM)?
From Des Moines Intl. (DSM), you can fly into Mid Delta Regional (GLH), Pitt-Greenville (PGV) and Greenville-Spartanburg Intl. (GSP) in Greenville. Some flights may connect through major hubs like O'Hare Intl. (ORD) before reaching Greenville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.
Travel information
Origin airport | Des Moines International Airport |
|---|---|
Destination airport | Greenville-Spartanburg Intl. Airport |
Distance | 770 miles away |
Airlines serving | American Airlines, Delta, United, Southwest Airlines |
Popular airline | American Airlines |
Roundtrip price | $269 |