$129 Cheap Flights from Des Moines (DSM) to Greenville (GSP)

View $129 flight on Tue, Nov 4, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)

Cheap Flights from Des Moines to Greenville (DSM-GSP)

Prices were available within the past 7 days and start at $129 for one-way flights and $219 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Oct 21 - Sat, Nov 8
DSM
Des Moines
GSP
Greenville
$219 Roundtrip, found 5 days ago
$219
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Oct 21 from Des Moines to Greenville, returning Sat, Nov 8, priced at $219 found 5 days ago
United
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
GSP
Greenville
$220 Roundtrip, found 6 days ago
$220
Roundtrip
found 6 days ago
Select United flight, departing Sat, Oct 11 from Des Moines to Greenville, returning Tue, Oct 14, priced at $220 found 6 days ago
United
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
GSP
Greenville
$225 Roundtrip, found 6 days ago
$225
Roundtrip
found 6 days ago
Select United flight, departing Sat, Oct 11 from Des Moines to Greenville, returning Tue, Oct 14, priced at $225 found 6 days ago
United
Tue, Nov 4 - Thu, Nov 6
DSM
Des Moines
GSP
Greenville
$251 Roundtrip, found 6 days ago
$251
Roundtrip
found 6 days ago
Select United flight, departing Tue, Nov 4 from Des Moines to Greenville, returning Thu, Nov 6, priced at $251 found 6 days ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
GSP
Greenville
$255 Roundtrip, found 6 days ago
$255
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 11 from Des Moines to Greenville, returning Tue, Oct 14, priced at $255 found 6 days ago
American Airlines
Wed, Oct 15 - Sat, Oct 18
DSM
Des Moines
GSP
Greenville
$257 Roundtrip, found 4 hours ago
$257
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Oct 15 from Des Moines to Greenville, returning Sat, Oct 18, priced at $257 found 4 hours ago
United
Wed, Oct 15 - Sat, Oct 18
DSM
Des Moines
GSP
Greenville
$257 Roundtrip, found 4 hours ago
$257
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Oct 15 from Des Moines to Greenville, returning Sat, Oct 18, priced at $257 found 4 hours ago
United
Wed, Oct 15 - Sat, Oct 18
DSM
Des Moines
GSP
Greenville
$258 Roundtrip, found 4 hours ago
$258
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Oct 15 from Des Moines to Greenville, returning Sat, Oct 18, priced at $258 found 4 hours ago
American Airlines
Sat, Oct 11 - Sat, Oct 18
DSM
Des Moines
GSP
Greenville
$261 Roundtrip, found 18 hours ago
$261
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Des Moines to Greenville, returning Sat, Oct 18, priced at $261 found 18 hours ago
Southwest Airlines
Wed, Jan 7 - Sat, Jan 10
DSM
Des Moines
GSP
Greenville
$282 Roundtrip, found 4 hours ago
$282
Roundtrip
found 4 hours ago
Select Southwest Airlines flight, departing Wed, Jan 7 from Des Moines to Greenville, returning Sat, Jan 10, priced at $282 found 4 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Greenville (GSP)

August is typically the cheapest month to fly

From $174 - $526 per traveler.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP) cost?
Secure a cheap one-way flight from $129 or cheap return flight from $219 from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
October is the most affordable month to fly from DSM to GSP. Traveling outside of peak seasons is often the key to landing a great deal.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
To find the cheapest airline that'll fly you from DSM to GSP, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
There are no daily nonstop flights from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from DSM to GSP?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
To arrive at Greenville-Spartanburg Intl. Airport (GSP) without delays, choose a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP) last-minute?
Last-minute bookings from DSM to GSP are typically more expensive. To lock in the lowest prices, start searching for flights well in advance. That being said, if you're flexible with your travel dates, you may score a cheap ticket right before you leave.
Is it cheaper to book a DSM to GSP flight and hotel package?
You'll typically save money by securing a DSM to GSP flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your preferred accommodations and flights, you can add extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
Typically, you can cancel or modify your DSM to GSP flight. However, there may be additional charges, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you want further details, visit our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$218
Distance
770 mi

Book with confidence

Book with confidence

Des Moines to Greenville Flights

The cheapest times to fly from Des Moines to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Greenville are during the month of October. You can find some of the cheapest flights from Des Moines to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Greenville

Sunday is one of the best days to book for cheap flights from Des Moines to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $129 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Greenville Flights

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Explore a world of travel with Expedia

*Available to One Key members.