$684 Cheap Flights from Des Moines (DSM) to Johannesburg (JNB)

View $684 flight on Mon, Jan 12, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to O.R. Tambo Intl. Airport (JNB)

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Cheap Flights from Des Moines to Johannesburg (DSM-JNB)

Prices were available within the past 7 days and start at $684 for one-way flights and $1,234 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Apr 23 - Thu, Apr 30
DSM
Des Moines
JNB
Johannesburg
$1,234 Roundtrip, found 7 hours ago
$1,234
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Thu, Apr 23 from Des Moines to Johannesburg, returning Thu, Apr 30, priced at $1,234 found 7 hours ago
American Airlines
Wed, Apr 22 - Thu, Apr 30
DSM
Des Moines
JNB
Johannesburg
$1,259 Roundtrip, found 7 hours ago
$1,259
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Apr 22 from Des Moines to Johannesburg, returning Thu, Apr 30, priced at $1,259 found 7 hours ago
American Airlines
Sat, Apr 25 - Sun, May 3
DSM
Des Moines
JNB
Johannesburg
$1,262 Roundtrip, found 7 hours ago
$1,262
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Apr 25 from Des Moines to Johannesburg, returning Sun, May 3, priced at $1,262 found 7 hours ago
American Airlines
Fri, Feb 13 - Wed, Feb 18
DSM
Des Moines
JNB
Johannesburg
$1,265 Roundtrip, found 1 day ago
$1,265
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Feb 13 from Des Moines to Johannesburg, returning Wed, Feb 18, priced at $1,265 found 1 day ago
American Airlines
Wed, Apr 22 - Sat, May 2
DSM
Des Moines
JNB
Johannesburg
$1,284 Roundtrip, found 7 hours ago
$1,284
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Apr 22 from Des Moines to Johannesburg, returning Sat, May 2, priced at $1,284 found 7 hours ago
American Airlines
Fri, Feb 13 - Wed, Feb 18
DSM
Des Moines
JNB
Johannesburg
$1,290 Roundtrip, found 1 day ago
$1,290
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Feb 13 from Des Moines to Johannesburg, returning Wed, Feb 18, priced at $1,290 found 1 day ago
Qatar Airways
Sun, Apr 26 - Thu, Apr 30
DSM
Des Moines
JNB
Johannesburg
$1,371 Roundtrip, found 7 hours ago
$1,371
Roundtrip
found 7 hours ago
Select Qatar Airways flight, departing Sun, Apr 26 from Des Moines to Johannesburg, returning Thu, Apr 30, priced at $1,371 found 7 hours ago
British Airways
Fri, Dec 5 - Mon, Dec 8
DSM
Des Moines
JNB
Johannesburg
$1,434 Roundtrip, found 16 hours ago
$1,434
Roundtrip
found 16 hours ago
Select British Airways flight, departing Fri, Dec 5 from Des Moines to Johannesburg, returning Mon, Dec 8, priced at $1,434 found 16 hours ago
United
Mon, Jan 12 - Mon, Jan 26
DSM
Des Moines
JNB
Johannesburg
$1,546 Roundtrip, found 2 days ago
$1,546
Roundtrip
found 2 days ago
Select United flight, departing Mon, Jan 12 from Des Moines to Johannesburg, returning Mon, Jan 26, priced at $1,546 found 2 days ago
Lufthansa
Fri, Feb 6 - Fri, Feb 13
DSM
Des Moines
JNB
Johannesburg
$1,582 Roundtrip, found 3 hours ago
$1,582
Roundtrip
found 3 hours ago
Select Lufthansa flight, departing Fri, Feb 6 from Des Moines to Johannesburg, returning Fri, Feb 13, priced at $1,582 found 3 hours ago

Alternative airports near Johannesburg

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O.R. Tambo Intl. JNB. Cheapest option available. Average driving time to city center is 17 minutes. Flights from $1,460
JNB
O.R. Tambo Intl.
Cheapest
Average driving time to city center17 min
Flights from $1,460

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB) cost?
Snag a cheap one-way flight from $684 or cheap return flight from $1,234 from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB)?
Traveling in April is a great way to save, as it's the cheapest month for flights between DSM and JNB. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to JNB. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB)?
You'll have to catch a flight with a layover if you're traveling from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from DSM to JNB?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB)?
To reach O.R. Tambo Intl. Airport (JNB) on schedule, choose a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB) last-minute?
Holding off until just before your trip to book a flight from DSM to JNB often results in higher prices. While you may find some last-minute deals, there's no guarantee. Be flexible with your itinerary for a better chance of snagging a bargain.
Is it cheaper to book a DSM to JNB flight and hotel package?
You'll typically save money by securing a DSM to JNB flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've chosen your preferred flights and accommodations, consider other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to O.R. Tambo Intl. Airport (JNB)?
If you reserved your DSM to JNB flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
O.R. Tambo Intl.
Airlines serving
Air France, American Airlines, British Airways, Delta, KLM, Lufthansa, Qatar Airways, United, Virgin Atlantic
Roundtrip price
$1,234
Distance
9003 mi

Book with confidence

Des Moines to Johannesburg Flights

The cheapest times to fly from Des Moines to Johannesburg

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Johannesburg are during the month of April. You can find some of the cheapest flights from Des Moines to Johannesburg with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Johannesburg

Sunday is one of the best days to book for cheap flights from Des Moines to Johannesburg: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Johannesburg

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Johannesburg in 2025. You can also book with separate airlines for your outbound and return journeys, from $684 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Johannesburg flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Johannesburg airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Johannesburg Flights

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*Available to One Key members.