$319 Cheap Flights from Detroit (DTW) to Panama City (PTY)

View $319 flight on Sun, Nov 23, 2025Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Detroit to Panama City (DTW-PTY)

Prices were available within the past 7 days and start at $319 for one-way flights and $491 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, Oct 22 - Wed, Oct 29
DTW
Detroit
PTY
Panama City
$491 Roundtrip, found 18 hours ago
$491
Roundtrip
found 18 hours ago
Select United flight, departing Wed, Oct 22 from Detroit to Panama City, returning Wed, Oct 29, priced at $491 found 18 hours ago
American Airlines
Tue, Oct 7 - Wed, Oct 15
DTW
Detroit
PTY
Panama City
$496 Roundtrip, found 1 day ago
$496
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 7 from Detroit to Panama City, returning Wed, Oct 15, priced at $496 found 1 day ago
United
Tue, Oct 7 - Wed, Oct 15
DTW
Detroit
PTY
Panama City
$499 Roundtrip, found 1 day ago
$499
Roundtrip
found 1 day ago
Select United flight, departing Tue, Oct 7 from Detroit to Panama City, returning Wed, Oct 15, priced at $499 found 1 day ago
United
Tue, Oct 7 - Tue, Oct 14
DTW
Detroit
PTY
Panama City
$503 Roundtrip, found 2 days ago
$503
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 7 from Detroit to Panama City, returning Tue, Oct 14, priced at $503 found 2 days ago
United
Wed, Oct 15 - Thu, Oct 23
DTW
Detroit
PTY
Panama City
$512 Roundtrip, found 2 days ago
$512
Roundtrip
found 2 days ago
Select United flight, departing Wed, Oct 15 from Detroit to Panama City, returning Thu, Oct 23, priced at $512 found 2 days ago
United
Wed, Oct 1 - Thu, Oct 9
DTW
Detroit
PTY
Panama City
$530 Roundtrip, found 3 days ago
$530
Roundtrip
found 3 days ago
Select United flight, departing Wed, Oct 1 from Detroit to Panama City, returning Thu, Oct 9, priced at $530 found 3 days ago
Delta
Wed, Oct 29 - Mon, Nov 10
DTW
Detroit
PTY
Panama City
$535 Roundtrip, found 1 day ago
$535
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Oct 29 from Detroit to Panama City, returning Mon, Nov 10, priced at $535 found 1 day ago
Delta
Wed, Oct 29 - Sat, Nov 8
DTW
Detroit
PTY
Panama City
$560 Roundtrip, found 1 day ago
$560
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Oct 29 from Detroit to Panama City, returning Sat, Nov 8, priced at $560 found 1 day ago
Delta
Mon, Oct 13 - Tue, Nov 4
DTW
Detroit
PTY
Panama City
$562 Roundtrip, found 2 days ago
$562
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Oct 13 from Detroit to Panama City, returning Tue, Nov 4, priced at $562 found 2 days ago
Copa
Thu, Jan 8 - Sat, Jan 17
DTW
Detroit
PTY
Panama City
$753 Roundtrip, found 14 hours ago
$753
Roundtrip
found 14 hours ago
Select Copa flight, departing Thu, Jan 8 from Detroit to Panama City, returning Sat, Jan 17, priced at $753 found 14 hours ago

Find the cheapest month to fly from Detroit (DTW) to Panama City (PTY)

November is typically the cheapest month to fly

From $519 - $1,025 per traveler.

Graph displaying average flight prices per month

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $766
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $766
Flights from Detroit (DTW) to Panama City (PTY)
Origin airport
Detroit Metropolitan Wayne County
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$491
Distance
2303 mi

Detroit to Panama City Flights

The cheapest times to fly from Detroit to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Panama City are during the month of October. You can find some of the cheapest flights from Detroit to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to Panama City

Sunday is one of the best days to book for cheap flights from Detroit to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $319 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from DTW to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DTW to PTY?
The cheapest flights from DTW to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DTW to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from DTW to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
Nonstop flights from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DTW to PTY?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
To reach Tocumen Intl. Airport (PTY) on time, choose a flight that takes off from Detroit Metropolitan Wayne County Airport (DTW) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) last-minute?
Waiting until right before your break to book a ticket from DTW to PTY often results in higher prices. While you might find some last-minute offers, they're not always guaranteed. Allow some flexibility in your schedule to boost your chances of scoring a bargain.
Is it cheaper to book a DTW to PTY flight and hotel package?
You can save money by securing a DTW to PTY flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've chosen your ideal accommodations and flights, consider adding extras such as tours, activities and car rentals.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
If you reserved your DTW to PTY flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

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*Available to One Key members.