$452 Cheap Flights from Detroit (DTW) to Sao Luis (SLZ)

View $452 flight on Mon, Nov 17, 2025Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Sao Luis (SLZ-Marechal Cunha Machado Intl.)

Cheap Flights from Detroit to Sao Luis (DTW-SLZ)

Prices were available within the past 7 days and start at $452 for one-way flights and $951 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Sep 3 - Wed, Oct 15
DTW
Detroit
SLZ
São Luís
$951 Roundtrip, found 23 hours ago
$951
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Sep 3 from Detroit to São Luís, returning Wed, Oct 15, priced at $951 found 23 hours ago
American Airlines
Wed, Sep 10 - Mon, Oct 20
DTW
Detroit
SLZ
São Luís
$1,019 Roundtrip, found 1 day ago
$1,019
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 10 from Detroit to São Luís, returning Mon, Oct 20, priced at $1,019 found 1 day ago
American Airlines
Wed, Sep 3 - Wed, Oct 15
DTW
Detroit
SLZ
São Luís
$1,091 Roundtrip, found 23 hours ago
$1,091
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Sep 3 from Detroit to São Luís, returning Wed, Oct 15, priced at $1,091 found 23 hours ago
American Airlines
Wed, Sep 3 - Wed, Oct 15
DTW
Detroit
SLZ
São Luís
$1,092 Roundtrip, found 23 hours ago
$1,092
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Sep 3 from Detroit to São Luís, returning Wed, Oct 15, priced at $1,092 found 23 hours ago
American Airlines
Mon, Nov 17 - Mon, Jan 12
DTW
Detroit
SLZ
São Luís
$1,097 Roundtrip, found 6 days ago
$1,097
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Nov 17 from Detroit to São Luís, returning Mon, Jan 12, priced at $1,097 found 6 days ago
United
Thu, Sep 25 - Tue, Nov 11
DTW
Detroit
SLZ
São Luís
$1,153 Roundtrip, found 5 hours ago
$1,153
Roundtrip
found 5 hours ago
Select United flight, departing Thu, Sep 25 from Detroit to São Luís, returning Tue, Nov 11, priced at $1,153 found 5 hours ago
American Airlines
Wed, Sep 3 - Wed, Oct 15
DTW
Detroit
SLZ
São Luís
$1,154 Roundtrip, found 23 hours ago
$1,154
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Sep 3 from Detroit to São Luís, returning Wed, Oct 15, priced at $1,154 found 23 hours ago
Delta
Wed, Dec 17 - Mon, Dec 22
DTW
Detroit
SLZ
São Luís
$1,225 Roundtrip, found 4 days ago
$1,225
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Dec 17 from Detroit to São Luís, returning Mon, Dec 22, priced at $1,225 found 4 days ago
Air Canada
Tue, Sep 23 - Thu, Nov 13
DTW
Detroit
SLZ
São Luís
$1,231 Roundtrip, found 2 hours ago
$1,231
Roundtrip
found 2 hours ago
Select Air Canada flight, departing Tue, Sep 23 from Detroit to São Luís, returning Thu, Nov 13, priced at $1,231 found 2 hours ago
LATAM Airlines Group
Sat, Jan 24 - Thu, Jan 29
DTW
Detroit
SLZ
São Luís
$1,270 Roundtrip, found 4 days ago
$1,270
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Sat, Jan 24 from Detroit to São Luís, returning Thu, Jan 29, priced at $1,270 found 4 days ago
Flights from Detroit (DTW) to Sao Luis (SLZ)
Origin airport
Detroit Metropolitan Wayne County
Destination airport
Marechal Cunha Machado Intl.
Airlines serving
Delta, GOL Linhas Aereas S.A., LATAM Airlines Group
Roundtrip price
$950
Distance
3942 mi

Detroit to Sao Luis Flights

The cheapest times to fly from Detroit to Sao Luis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Sao Luis are during the month of September. You can find some of the cheapest flights from Detroit to Sao Luis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to Sao Luis

Sunday is one of the best days to book for cheap flights from Detroit to Sao Luis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to Sao Luis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Sao Luis in 2025. You can also book with separate airlines for your outbound and return journeys, from $452 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Sao Luis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Sao Luis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ) cost?
Grab a cheap one-way flight from $452 or cheap return flight from $951 from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ)?
The cheapest month to fly from DTW to SLZ is September, when demand is low. Off-peak season is generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DTW to SLZ flight.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ)?
You'll have to book a flight with a layover if you're traveling from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from DTW to SLZ?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary depending on a number of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ)?
Select a flight from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ) last-minute?
Last-minute fares from DTW to SLZ are usually more expensive. For the lowest prices, start looking for flights as early as possible. That being said, if you can play around with your travel dates, you may land a cheap fare right before you leave.
Is it cheaper to book a DTW to SLZ flight and hotel package?
Booking a DTW to SLZ flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Pick from our extensive range of accommodations and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to Marechal Cunha Machado Intl. Airport (SLZ)?
If you reserved your DTW to SLZ flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

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*Available to One Key members.