$254 Cheap Flights from Panama City (ECP) to Santo Domingo (SDQ)

View $254 flight on Mon, Oct 27, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from Panama City to Santo Domingo (ECP-SDQ)

Prices were available within the past 7 days and start at $254 for one-way flights and $465 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Oct 8 - Tue, Oct 14
ECP
Panama City
SDQ
Santo Domingo
$465 Roundtrip, found 7 hours ago
$465
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, Oct 8 from Panama City to Santo Domingo, returning Tue, Oct 14, priced at $465 found 7 hours ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
ECP
Panama City
SDQ
Santo Domingo
$469 Roundtrip, found 7 hours ago
$469
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Panama City to Santo Domingo, returning Tue, Oct 14, priced at $469 found 7 hours ago
Delta
Mon, Sep 22 - Mon, Oct 6
ECP
Panama City
SDQ
Santo Domingo
$475 Roundtrip, found 6 hours ago
$475
Roundtrip
found 6 hours ago
Select Delta flight, departing Mon, Sep 22 from Panama City to Santo Domingo, returning Mon, Oct 6, priced at $475 found 6 hours ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
ECP
Panama City
SDQ
Santo Domingo
$477 Roundtrip, found 7 hours ago
$477
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Panama City to Santo Domingo, returning Tue, Oct 14, priced at $477 found 7 hours ago
American Airlines
Mon, Dec 8 - Fri, Feb 27
ECP
Panama City
SDQ
Santo Domingo
$477 Roundtrip, found 1 day ago
$477
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Dec 8 from Panama City to Santo Domingo, returning Fri, Feb 27, priced at $477 found 1 day ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
ECP
Panama City
SDQ
Santo Domingo
$479 Roundtrip, found 7 hours ago
$479
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Panama City to Santo Domingo, returning Tue, Oct 14, priced at $479 found 7 hours ago
American Airlines
Sun, Sep 21 - Sun, Oct 5
ECP
Panama City
SDQ
Santo Domingo
$484 Roundtrip, found 18 hours ago
$484
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Sun, Sep 21 from Panama City to Santo Domingo, returning Sun, Oct 5, priced at $484 found 18 hours ago
American Airlines
Fri, Oct 3 - Tue, Oct 7
ECP
Panama City
SDQ
Santo Domingo
$485 Roundtrip, found 14 hours ago
$485
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Oct 3 from Panama City to Santo Domingo, returning Tue, Oct 7, priced at $485 found 14 hours ago
American Airlines
Sun, Sep 28 - Sat, Oct 11
ECP
Panama City
SDQ
Santo Domingo
$487 Roundtrip, found 8 hours ago
$487
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Sun, Sep 28 from Panama City to Santo Domingo, returning Sat, Oct 11, priced at $487 found 8 hours ago
United
Sun, Sep 28 - Sat, Oct 11
ECP
Panama City
SDQ
Santo Domingo
$3,062 Roundtrip, found 8 hours ago
$3,062
Roundtrip
found 8 hours ago
Select United flight, departing Sun, Sep 28 from Panama City to Santo Domingo, returning Sat, Oct 11, priced at $3,062 found 8 hours ago

Find the cheapest month to fly from Panama City (ECP) to Santo Domingo (SDQ)

January is typically the cheapest month to fly

From $417 - $887 per traveler.

Graph displaying average flight prices per month

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $624
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $624
Flights from Panama City (ECP) to Santo Domingo (SDQ)
Origin airport
Northwest Florida Beaches Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$464
Distance
1304 mi

Panama City to Santo Domingo Flights

The cheapest times to fly from Panama City to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santo Domingo are during the month of October. You can find some of the cheapest flights from Panama City to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Santo Domingo

Sunday is one of the best days to book for cheap flights from Panama City to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $254 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ) cost?
Discover the latest flight deals from ECP to SDQ by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from ECP to SDQ?
The cheapest flights from ECP to SDQ are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from ECP to SDQ?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from ECP to SDQ. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ)?
Nonstop flights from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from ECP to SDQ?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary based on various factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ)?
To arrive at Las Americas Intl. Airport (SDQ) on time, opt for a flight that leaves Northwest Florida Beaches Intl. Airport (ECP) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ) last-minute?
Last-minute fares from ECP to SDQ are generally more expensive. To lock in the lowest rates, start searching for flights as early as possible. That being said, if you're flexible with your travel plans, you may score a cheap ticket right before your journey.
Is it cheaper to book an ECP to SDQ flight and hotel package?
Booking an ECP to SDQ flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our wide range of stays and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to Las Americas Intl. Airport (SDQ)?
Typically, you're able to reschedule or cancel your ECP to SDQ flight. However, additional charges may apply, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you need more information, go to our Customer Service portal.

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*Available to One Key members.