$173 Cheap Flights from Florence (FLO) to Chicago (ORD)

View $173 flight on Wed, May 27, 2026Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Chicago O'Hare Intl. Airport (ORD)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Florence to Chicago (FLO-ORD)

Prices were available within the past 7 days and start at $173 for one-way flights and $325 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Apr 6 - Thu, Apr 9
FLO
Florence
ORD
Chicago
$325 Roundtrip, found 2 days ago
$325
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Apr 6 from Florence to Chicago, returning Thu, Apr 9, priced at $325 found 2 days ago
American Airlines
Sat, Apr 25 - Fri, May 1
FLO
Florence
ORD
Chicago
$337 Roundtrip, found 6 days ago
$337
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Apr 25 from Florence to Chicago, returning Fri, May 1, priced at $337 found 6 days ago
American Airlines
Wed, May 27 - Sat, May 30
FLO
Florence
ORD
Chicago
$345 Roundtrip, found 5 hours ago
$345
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, May 27 from Florence to Chicago, returning Sat, May 30, priced at $345 found 5 hours ago
American Airlines
Mon, Apr 6 - Thu, Apr 9
FLO
Florence
ORD
Chicago
$360 Roundtrip, found 2 days ago
$360
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Apr 6 from Florence to Chicago, returning Thu, Apr 9, priced at $360 found 2 days ago
American Airlines
Fri, Apr 10 - Sun, Apr 12
FLO
Florence
ORD
Chicago
$371 Roundtrip, found 5 days ago
$371
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Apr 10 from Florence to Chicago, returning Sun, Apr 12, priced at $371 found 5 days ago
American Airlines
Sat, Apr 25 - Fri, May 1
FLO
Florence
ORD
Chicago
$372 Roundtrip, found 6 days ago
$372
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Apr 25 from Florence to Chicago, returning Fri, May 1, priced at $372 found 6 days ago
American Airlines
Wed, May 20 - Wed, May 27
FLO
Florence
ORD
Chicago
$373 Roundtrip, found 5 days ago
$373
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 20 from Florence to Chicago, returning Wed, May 27, priced at $373 found 5 days ago
American Airlines
Fri, Apr 10 - Sun, Apr 12
FLO
Florence
ORD
Chicago
$376 Roundtrip, found 5 days ago
$376
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Apr 10 from Florence to Chicago, returning Sun, Apr 12, priced at $376 found 5 days ago
American Airlines
Wed, May 27 - Sat, May 30
FLO
Florence
ORD
Chicago
$380 Roundtrip, found 5 hours ago
$380
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, May 27 from Florence to Chicago, returning Sat, May 30, priced at $380 found 5 hours ago
American Airlines
Sat, May 16 - Mon, May 18
FLO
Florence
ORD
Chicago
$395 Roundtrip, found 1 day ago
$395
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 16 from Florence to Chicago, returning Mon, May 18, priced at $395 found 1 day ago

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.
Book now

Alternative airports near Chicago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O'Hare Intl. ORD. Cheapest option available. Average driving time to city center is 23 minutes. Flights from $481
ORD
O'Hare Intl.
Cheapest
Average driving time to city center23 min
Flights from $481

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD) cost?
Lock in a cheap one-way flight from $173 or cheap return flight from $325 from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD)?
The cheapest month to fly from FLO to ORD is April, when demand is low. Off-peak months are often when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD)?
To find the cheapest airline flying from FLO to ORD, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD)?
There aren't any daily nonstop flights available from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from FLO to ORD?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can change depending on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD)?
Book a flight from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD) that takes off before 3 PM to reduce the risk of cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD) last-minute?
Waiting until right before your break to book a ticket from FLO to ORD generally means paying more. While you might find some last-minute offers, there's no guarantee. Keep your travel plans flexible to maximize your chances of getting a bargain.
Is it cheaper to book a FLO to ORD flight and hotel package?
Booking a FLO to ORD flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our wide range of hotels and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to O'Hare Intl. Airport (ORD)?
If you booked your FLO to ORD flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

Travel information

Origin airport
Florence Regional
Destination airport
O'Hare Intl.
Airlines serving
American Airlines
Roundtrip price
$324
Distance
697 mi

Book with confidence

Florence to Chicago Flights

The cheapest times to fly from Florence to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Chicago are during the month of April. You can find some of the cheapest flights from Florence to Chicago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Chicago

Sunday is one of the best days to book for cheap flights from Florence to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Chicago in 2026. You can also book with separate airlines for your outbound and return journeys, from $173 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Chicago Flights

*Flight schedules are subject to change.

Explore a world of travel with Expedia

*Available to One Key members.