$453 Cheap Flights from Lisbon (LIS) to Santo Domingo (SDQ)

View $453 flight on Sun, Mar 22, 2026Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to Santo Domingo

Cheap Flights from Lisbon to Santo Domingo (LIS-SDQ)

Prices were available within the past 7 days and start at $453 for one-way flights and $783 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Thu, Jan 29 - Sun, Feb 15
LIS
Lisbon
SDQ
Santo Domingo
$783 Roundtrip, found 6 days ago
$783
Roundtrip
found 6 days ago
Select Air Europa flight, departing Thu, Jan 29 from Lisbon to Santo Domingo, returning Sun, Feb 15, priced at $783 found 6 days ago
Iberia
Thu, May 21 - Thu, May 28
LIS
Lisbon
SDQ
Santo Domingo
$783 Roundtrip, found 5 days ago
$783
Roundtrip
found 5 days ago
Select Iberia flight, departing Thu, May 21 from Lisbon to Santo Domingo, returning Thu, May 28, priced at $783 found 5 days ago
Air Europa
Thu, Feb 5 - Fri, Feb 20
LIS
Lisbon
SDQ
Santo Domingo
$791 Roundtrip, found 6 days ago
$791
Roundtrip
found 6 days ago
Select Air Europa flight, departing Thu, Feb 5 from Lisbon to Santo Domingo, returning Fri, Feb 20, priced at $791 found 6 days ago
Iberia
Thu, Mar 5 - Thu, Mar 12
LIS
Lisbon
SDQ
Santo Domingo
$798 Roundtrip, found 3 days ago
$798
Roundtrip
found 3 days ago
Select Iberia flight, departing Thu, Mar 5 from Lisbon to Santo Domingo, returning Thu, Mar 12, priced at $798 found 3 days ago
Air Europa
Sat, Feb 7 - Fri, Feb 20
LIS
Lisbon
SDQ
Santo Domingo
$802 Roundtrip, found 6 days ago
$802
Roundtrip
found 6 days ago
Select Air Europa flight, departing Sat, Feb 7 from Lisbon to Santo Domingo, returning Fri, Feb 20, priced at $802 found 6 days ago
Iberia
Thu, Mar 5 - Thu, Mar 12
LIS
Lisbon
SDQ
Santo Domingo
$806 Roundtrip, found 3 days ago
$806
Roundtrip
found 3 days ago
Select Iberia flight, departing Thu, Mar 5 from Lisbon to Santo Domingo, returning Thu, Mar 12, priced at $806 found 3 days ago
Air Europa
Wed, Jan 21 - Sun, Feb 8
LIS
Lisbon
SDQ
Santo Domingo
$818 Roundtrip, found 6 days ago
$818
Roundtrip
found 6 days ago
Select Air Europa flight, departing Wed, Jan 21 from Lisbon to Santo Domingo, returning Sun, Feb 8, priced at $818 found 6 days ago
Delta
Wed, Jan 21 - Wed, Jan 28
LIS
Lisbon
SDQ
Santo Domingo
$896 Roundtrip, found 6 days ago
$896
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Jan 21 from Lisbon to Santo Domingo, returning Wed, Jan 28, priced at $896 found 6 days ago
United
Wed, Jan 21 - Sun, Jan 25
LIS
Lisbon
SDQ
Santo Domingo
$968 Roundtrip, found 6 days ago
$968
Roundtrip
found 6 days ago
Select United flight, departing Wed, Jan 21 from Lisbon to Santo Domingo, returning Sun, Jan 25, priced at $968 found 6 days ago
KLM
Sat, Jan 24 - Thu, Jan 29
LIS
Lisbon
SDQ
Santo Domingo
$1,125 Roundtrip, found 2 days ago
$1,125
Roundtrip
found 2 days ago
Select KLM flight, departing Sat, Jan 24 from Lisbon to Santo Domingo, returning Thu, Jan 29, priced at $1,125 found 2 days ago

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $1,144
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $1,144
Flights from Lisbon (LIS) to Santo Domingo (SDQ)
Origin airport
Humberto Delgado
Destination airport
Las Americas Intl.
Airlines serving
Air Europa, American Airlines, British Airways, Delta, Iberia, KLM, United
Roundtrip price
$783
Distance
3857 mi

Lisbon to Santo Domingo Flights

The cheapest times to fly from Lisbon to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lisbon to Santo Domingo are during the month of January. You can find some of the cheapest flights from Lisbon to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lisbon to Santo Domingo

Sunday is one of the best days to book for cheap flights from Lisbon to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lisbon to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lisbon to Santo Domingo in 2026. You can also book with separate airlines for your outbound and return journeys, from $453 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lisbon to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lisbon to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ) cost?
Snag a cheap one-way flight from $453 or cheap return flight from $783 from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ)?
Flying in January may help you find better deals, as it's the cheapest month for flights between LIS and SDQ. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from LIS to SDQ. Then, sort your results by "Price (lowest to highest)" to score a great deal.
How many flights per day from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ)?
There aren't any daily direct flights departing from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ). But you can opt for flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from LIS to SDQ?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* But this can change based on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ)?
To avoid possible delays on the Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ) route, fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ) last-minute?
Holding off until right before your break to book your flight from LIS to SDQ generally means paying more. While you may find some last-minute discounts, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of scoring a bargain.
Is it cheaper to book a LIS to SDQ flight and hotel package?
You'll typically save money by securing a LIS to SDQ flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your ideal flights and accommodations, consider adding extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Humberto Delgado Airport (LIS) to Las Americas Intl. Airport (SDQ)?
In most instances, you can cancel or reschedule your LIS to SDQ flight. However, additional charges may apply, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's guidelines and fees on flight changes, or if you need more information, go to our Customer Service portal.

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*Available to One Key members.