$348 Cheap Flights from Lisbon (LIS) to São Tomé Island (TMS)

View $348 flight on Sun, Sep 28, 2025Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to São Tomé Island (TMS-São Tomé Intl.)

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Cheap Flights from Lisbon to São Tomé Island (LIS-TMS)

Prices were available within the past 7 days and start at $348 for one-way flights and $557 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

TAAG Angola Airlines
Thu, Sep 25 - Mon, Sep 29
LIS
Lisbon
TMS
São Tomé Island
$557 Roundtrip, found 1 day ago
$557
Roundtrip
found 1 day ago
Select TAAG Angola Airlines flight, departing Thu, Sep 25 from Lisbon to São Tomé Island, returning Mon, Sep 29, priced at $557 found 1 day ago
TAP Portugal
Wed, Jan 7 - Wed, Jan 21
LIS
Lisbon
TMS
São Tomé Island
$567 Roundtrip, found 3 days ago
$567
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Wed, Jan 7 from Lisbon to São Tomé Island, returning Wed, Jan 21, priced at $567 found 3 days ago
TAAG Angola Airlines
Sun, Dec 28 - Mon, Jan 12
LIS
Lisbon
TMS
São Tomé Island
$587 Roundtrip, found 3 days ago
$587
Roundtrip
found 3 days ago
Select TAAG Angola Airlines flight, departing Sun, Dec 28 from Lisbon to São Tomé Island, returning Mon, Jan 12, priced at $587 found 3 days ago
TAAG Angola Airlines
Thu, Dec 25 - Mon, Jan 12
LIS
Lisbon
TMS
São Tomé Island
$617 Roundtrip, found 3 days ago
$617
Roundtrip
found 3 days ago
Select TAAG Angola Airlines flight, departing Thu, Dec 25 from Lisbon to São Tomé Island, returning Mon, Jan 12, priced at $617 found 3 days ago
TAAG Angola Airlines
Sun, Dec 7 - Mon, Dec 22
LIS
Lisbon
TMS
São Tomé Island
$629 Roundtrip, found 3 days ago
$629
Roundtrip
found 3 days ago
Select TAAG Angola Airlines flight, departing Sun, Dec 7 from Lisbon to São Tomé Island, returning Mon, Dec 22, priced at $629 found 3 days ago
TAAG Angola Airlines
Thu, Dec 25 - Mon, Dec 29
LIS
Lisbon
TMS
São Tomé Island
$659 Roundtrip, found 3 days ago
$659
Roundtrip
found 3 days ago
Select TAAG Angola Airlines flight, departing Thu, Dec 25 from Lisbon to São Tomé Island, returning Mon, Dec 29, priced at $659 found 3 days ago
TAP Portugal
Wed, Nov 19 - Wed, Nov 26
LIS
Lisbon
TMS
São Tomé Island
$677 Roundtrip, found 5 days ago
$677
Roundtrip
found 5 days ago
Select TAP Portugal flight, departing Wed, Nov 19 from Lisbon to São Tomé Island, returning Wed, Nov 26, priced at $677 found 5 days ago
TAP Portugal
Fri, Nov 21 - Sun, Nov 30
LIS
Lisbon
TMS
São Tomé Island
$679 Roundtrip, found 4 hours ago
$679
Roundtrip
found 4 hours ago
Select TAP Portugal flight, departing Fri, Nov 21 from Lisbon to São Tomé Island, returning Sun, Nov 30, priced at $679 found 4 hours ago
TAP Portugal
Wed, Mar 4 - Fri, Mar 13
LIS
Lisbon
TMS
São Tomé Island
$680 Roundtrip, found 1 day ago
$680
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Wed, Mar 4 from Lisbon to São Tomé Island, returning Fri, Mar 13, priced at $680 found 1 day ago
TAAG Angola Airlines
Sun, Jan 4 - Wed, Jan 14
LIS
Lisbon
TMS
São Tomé Island
$683 Roundtrip, found 3 days ago
$683
Roundtrip
found 3 days ago
Select TAAG Angola Airlines flight, departing Sun, Jan 4 from Lisbon to São Tomé Island, returning Wed, Jan 14, priced at $683 found 3 days ago

Alternative airports near São Tomé

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Sao Tome Intl. TMS. Cheapest option available. Flights from $1,490
TMS
Sao Tome Intl.
Cheapest
Flights from $1,490
Flights from Lisbon (LIS) to São Tomé Island (TMS)
Origin airport
Humberto Delgado
Destination airport
São Tomé Intl.
Airlines serving
TAP Portugal
Roundtrip price
$556
Distance
2836 mi
Average flight time
7 hours 40 mins

Lisbon to São Tomé Island Flights

The cheapest times to fly from Lisbon to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lisbon to São Tomé Island are during the month of September. You can find some of the cheapest flights from Lisbon to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lisbon to São Tomé Island

Sunday is one of the best days to book for cheap flights from Lisbon to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lisbon to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lisbon to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $348 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lisbon to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lisbon to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS) cost?
Score cheap return tickets from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS) starting from $944. Grab a seat and get ready to go. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a TAP Portugal flight leaving LIS on August 9 2025 and touching down at TMS. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from LIS to TMS?
The cheapest flights from LIS to TMS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
You can fly directly from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS) on a TAP Portugal flight.
What is the cheapest airline that flies from LIS to TMS?
With prices starting from $670 for a one-way journey from LIS to TMS, TAP Portugal is currently the cheapest airline flying this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from LIS on August 23 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
On average you can take your pick of 2 direct flights every week from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS). To increase your travel options, consider taking a flight with a layover. Enter your dates on Expedia and then filter your search to include one stop or more.
What are the most popular departure times for flights from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
More passengers fly between LIS and TMS at 12 AM than at any other point in the day. Rather go when it's quieter? Pick a flight outside the busiest times and you could save on your fare as well.
What day of the week has the most flights from LIS to TMS?
If you fly on a Saturday, you'll get the largest range of options for flights from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS).
What is the earliest flight from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
The earliest flight leaving from Humberto Delgado Airport (LIS) is at around 12:05AM UTC+0. Catch this flight and you'll land at Sao Tome Intl. Airport (TMS) at approximately 6:20AM UTC+0. The entire trip takes 6h 15m.
How long does it take to fly from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
The average flight time from LIS to TMS is 6 hours and 25 minutes, covering a distance of 2,800 mi.
What airline has the least delays from LIS to TMS?
With 87% of journeys typically landing on time, STP Airways has the best on-time performance for direct flights from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS). To monitor your flight status and receive notifications if anything changes, head to the Expedia App.
What is the best time to fly from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
Opt for a flight from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for São Tomé Island from Humberto Delgado Airport (LIS)?
If you're traveling on a direct flight from Humberto Delgado Airport (LIS) to São Tomé Island, Sao Tome Intl. Airport (TMS) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS) last-minute?
Waiting until right before your break to book a ticket from LIS to TMS generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Keep your travel plans flexible to boost your chances of getting a bargain.
Is it cheaper to book a LIS to TMS flight and hotel package?
Compared with arranging flights and hotels separately, booking a LIS to TMS flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one convenient place takes the hassle out of planning your trip. Just secure your flights and select from our wide range of hotels, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Humberto Delgado Airport (LIS) to Sao Tome Intl. Airport (TMS)?
If you reserved your LIS to TMS flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

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*Available to One Key members.