$675 Cheap Flights from Lyon (LYS) to Panama City (PTY)

View $675 flight on Mon, Jan 19, 2026Opens in a new window

Popular airlines from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY)

Cheap Flights from Lyon to Panama City (LYS-PTY)

Prices were available within the past 7 days and start at $675 for one-way flights and $1,145 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Iberia
Sat, Nov 22 - Tue, Nov 25
LYS
Lyon
PTY
Panama City
$1,145 Roundtrip, found 5 days ago
$1,145
Roundtrip
found 5 days ago
Select Iberia flight, departing Sat, Nov 22 from Lyon to Panama City, returning Tue, Nov 25, priced at $1,145 found 5 days ago
Iberia
Sat, Nov 22 - Tue, Nov 25
LYS
Lyon
PTY
Panama City
$1,155 Roundtrip, found 5 days ago
$1,155
Roundtrip
found 5 days ago
Select Iberia flight, departing Sat, Nov 22 from Lyon to Panama City, returning Tue, Nov 25, priced at $1,155 found 5 days ago
Iberia
Sat, Nov 22 - Tue, Nov 25
LYS
Lyon
PTY
Panama City
$1,168 Roundtrip, found 5 days ago
$1,168
Roundtrip
found 5 days ago
Select Iberia flight, departing Sat, Nov 22 from Lyon to Panama City, returning Tue, Nov 25, priced at $1,168 found 5 days ago
Turkish Airlines
Fri, Feb 13 - Sat, Feb 28
LYS
Lyon
PTY
Panama City
$1,170 Roundtrip, found 1 day ago
$1,170
Roundtrip
found 1 day ago
Select Turkish Airlines flight, departing Fri, Feb 13 from Lyon to Panama City, returning Sat, Feb 28, priced at $1,170 found 1 day ago
Iberia
Sat, Feb 14 - Sat, Feb 28
LYS
Lyon
PTY
Panama City
$1,197 Roundtrip, found 1 day ago
$1,197
Roundtrip
found 1 day ago
Select Iberia flight, departing Sat, Feb 14 from Lyon to Panama City, returning Sat, Feb 28, priced at $1,197 found 1 day ago
Iberia
Sat, Feb 14 - Sat, Feb 28
LYS
Lyon
PTY
Panama City
$1,213 Roundtrip, found 1 day ago
$1,213
Roundtrip
found 1 day ago
Select Iberia flight, departing Sat, Feb 14 from Lyon to Panama City, returning Sat, Feb 28, priced at $1,213 found 1 day ago
Iberia
Sat, Nov 22 - Tue, Nov 25
LYS
Lyon
PTY
Panama City
$1,234 Roundtrip, found 5 days ago
$1,234
Roundtrip
found 5 days ago
Select Iberia flight, departing Sat, Nov 22 from Lyon to Panama City, returning Tue, Nov 25, priced at $1,234 found 5 days ago
British Airways
Sat, Feb 14 - Sat, Feb 28
LYS
Lyon
PTY
Panama City
$1,376 Roundtrip, found 1 day ago
$1,376
Roundtrip
found 1 day ago
Select British Airways flight, departing Sat, Feb 14 from Lyon to Panama City, returning Sat, Feb 28, priced at $1,376 found 1 day ago
United
Thu, Dec 25 - Sun, Jan 4
LYS
Lyon
PTY
Panama City
$2,002 Roundtrip, found 11 hours ago
$2,002
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 25 from Lyon to Panama City, returning Sun, Jan 4, priced at $2,002 found 11 hours ago
KLM
Thu, Dec 25 - Sun, Jan 4
LYS
Lyon
PTY
Panama City
$2,023 Roundtrip, found 11 hours ago
$2,023
Roundtrip
found 11 hours ago
Select KLM flight, departing Thu, Dec 25 from Lyon to Panama City, returning Sun, Jan 4, priced at $2,023 found 11 hours ago
Flights from Lyon (LYS) to Panama City (PTY)
Origin airport
Saint-Exupery
Destination airport
Tocumen Intl.
Airlines serving
Air France, Delta, Iberia, KLM, United
Roundtrip price
$1,144
Distance
5504 mi

Lyon to Panama City Flights

The cheapest times to fly from Lyon to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to Panama City are during the month of November. You can find some of the cheapest flights from Lyon to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to Panama City

Sunday is one of the best days to book for cheap flights from Lyon to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $675 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY) cost?
Lock in a cheap one-way flight from $675 or cheap return flight from $1,145 from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from LYS to PTY is November, when demand is low. Off-peak season is usually when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest LYS to PTY flight.
How many flights per day from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY)?
Direct flights from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from LYS to PTY?
Generally you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* But this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY)?
To land at Tocumen Intl. Airport (PTY) without delays, choose a flight that takes off from Saint-Exupery Airport (LYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from LYS to PTY just before your getaway is typically more expensive. But if you're flexible with your itinerary, you could land a cheap last-minute fare.
Is it cheaper to book a LYS to PTY flight and hotel package?
You'll typically save money by securing a LYS to PTY flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've selected your ideal flights and accommodations, consider adding extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to Tocumen Intl. Airport (PTY)?
Usually, it's possible to reschedule or cancel your LYS to PTY flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.