$643 Cheap Flights from Medellín (MDE) to Santander (SDR)

View $643 flight on Fri, Dec 5, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Santander (SDR)

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Cheap Flights from Medellín to Santander (MDE-SDR)

Prices were available within the past 7 days and start at $643 for one-way flights and $1,632 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Mon, Oct 20 - Mon, Oct 27
MDE
Medellin
SDR
Santander
$1,632 Roundtrip, found 6 days ago
$1,632
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Oct 20 from Medellin to Santander, returning Mon, Oct 27, priced at $1,632 found 6 days ago
Iberia
Mon, Oct 20 - Mon, Oct 27
MDE
Medellin
SDR
Santander
$1,634 Roundtrip, found 6 days ago
$1,634
Roundtrip
found 6 days ago
Select Iberia flight, departing Mon, Oct 20 from Medellin to Santander, returning Mon, Oct 27, priced at $1,634 found 6 days ago

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR) cost?
Grab a cheap one-way flight from $643 or cheap return flight from $1,632 from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR)?
The cheapest month to fly from MDE to SDR is October, when there's less demand. Off-peak months are generally when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest MDE to SDR flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR)?
Direct flights from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDE to SDR?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary depending on various factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR)?
Select a flight from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR) that leaves before 3 PM to reduce the risk of cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR) last-minute?
Booking your flight from MDE to SDR just before your getaway is generally more expensive. However, if there's some wiggle room with your travel dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a MDE to SDR flight and hotel package?
You'll typically save money by booking a MDE to SDR flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. After selecting your ideal flights and accommodations, consider other add-ons like car rentals, activities and tours.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Santander Airport (SDR)?
If you reserved your MDE to SDR flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you'd like more information.

Travel information

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Santander
Roundtrip price
$1,631
Distance
5004 mi

Book with confidence

Book with confidence

Medellín to Santander Flights

The cheapest times to fly from Medellín to Santander

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santander are during the month of October. You can find some of the cheapest flights from Medellín to Santander with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santander

Sunday is one of the best days to book for cheap flights from Medellín to Santander: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santander

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santander in 2025. You can also book with separate airlines for your outbound and return journeys, from $643 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santander flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santander airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Santander Flights

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*Available to One Key members.