$269 Cheap Flights from Medellín (MDE) to Santiago (STI)

View $269 flight on Fri, Jan 23, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)

Cheap Flights from Medellín to Santiago (MDE-STI)

Prices were available within the past 7 days and start at $269 for one-way flights and $444 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Jan 19 - Mon, Feb 2
MDE
Medellin
STI
Santiago de los Caballeros
$444 Roundtrip, found 5 days ago
$444
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Jan 19 from Medellin to Santiago de los Caballeros, returning Mon, Feb 2, priced at $444 found 5 days ago
Copa
Thu, Jan 22 - Thu, Feb 12
MDE
Medellin
STI
Santiago de los Caballeros
$457 Roundtrip, found 5 days ago
$457
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Jan 22 from Medellin to Santiago de los Caballeros, returning Thu, Feb 12, priced at $457 found 5 days ago
Copa
Mon, Jan 19 - Thu, Feb 5
MDE
Medellin
STI
Santiago de los Caballeros
$468 Roundtrip, found 5 days ago
$468
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Jan 19 from Medellin to Santiago de los Caballeros, returning Thu, Feb 5, priced at $468 found 5 days ago
Copa
Fri, Feb 13 - Thu, Feb 19
MDE
Medellin
STI
Santiago de los Caballeros
$470 Roundtrip, found 4 days ago
$470
Roundtrip
found 4 days ago
Select Copa flight, departing Fri, Feb 13 from Medellin to Santiago de los Caballeros, returning Thu, Feb 19, priced at $470 found 4 days ago
Copa
Thu, Feb 5 - Mon, Feb 23
MDE
Medellin
STI
Santiago de los Caballeros
$481 Roundtrip, found 5 days ago
$481
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Feb 5 from Medellin to Santiago de los Caballeros, returning Mon, Feb 23, priced at $481 found 5 days ago
Copa
Sat, Jan 17 - Thu, Feb 5
MDE
Medellin
STI
Santiago de los Caballeros
$494 Roundtrip, found 5 days ago
$494
Roundtrip
found 5 days ago
Select Copa flight, departing Sat, Jan 17 from Medellin to Santiago de los Caballeros, returning Thu, Feb 5, priced at $494 found 5 days ago
Copa
Mon, Mar 16 - Mon, Mar 30
MDE
Medellin
STI
Santiago de los Caballeros
$496 Roundtrip, found 2 days ago
$496
Roundtrip
found 2 days ago
Select Copa flight, departing Mon, Mar 16 from Medellin to Santiago de los Caballeros, returning Mon, Mar 30, priced at $496 found 2 days ago
JetBlue Airways
Thu, Feb 5 - Sun, Feb 22
MDE
Medellin
STI
Santiago de los Caballeros
$622 Roundtrip, found 5 days ago
$622
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Thu, Feb 5 from Medellin to Santiago de los Caballeros, returning Sun, Feb 22, priced at $622 found 5 days ago
United
Mon, Apr 20 - Tue, May 5
MDE
Medellin
STI
Santiago de los Caballeros
$704 Roundtrip, found 2 days ago
$704
Roundtrip
found 2 days ago
Select United flight, departing Mon, Apr 20 from Medellin to Santiago de los Caballeros, returning Tue, May 5, priced at $704 found 2 days ago
American Airlines
Thu, Jan 15 - Tue, Jan 27
MDE
Medellin
STI
Santiago de los Caballeros
$1,109 Roundtrip, found 6 hours ago
$1,109
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Jan 15 from Medellin to Santiago de los Caballeros, returning Tue, Jan 27, priced at $1,109 found 6 hours ago

Find the cheapest month to fly from Medellín (MDE) to Santiago de los Caballeros (STI)

March is typically the cheapest month to fly

From $260 - $1,104 per traveler.

Alternative airports near Santiago de los Caballeros

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Gregorio Luperon Intl. POP. Cheapest option available. Average driving time to city center is 59 minutes. Flights from $1,028
POP
Gregorio Luperon Intl.
Cheapest
Average driving time to city center59 min
Flights from $1,028

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) cost?
Secure a cheap one-way flight from $269 or cheap return flight from $444 from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
January is the cheapest month to fly from MDE to STI. Avoiding peak travel times is often the key to landing a great deal.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
When heading out of Jose Maria Cordova Intl. Airport (MDE), you can take a direct flight to Cibao Intl. Airport (STI) with Arajet.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MDE to STI flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
On average, you can pick from 2 direct flights each week from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI). To broaden your travel options, consider a flight with a layover. Simply enter your details on Expedia and then filter your search to show one or more stops.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
More people fly between MDE and STI at 10 AM than at any other time. Prefer a quieter experience? Consider flying outside peak hours and you could save on your ticket as well.
What day of the week has the most flights from MDE to STI?
Thursday has the most flights from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI). Consider leaving on this day and you'll have the best chance of finding a departure that fits your plans.
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
The first flight of the day leaving Jose Maria Cordova Intl. Airport (MDE) is at around 10:50AM UTC-5. Board this plane and you'll reach Cibao Intl. Airport (STI) at approximately 2:30PM UTC-4. The total flight duration is 2h 40m.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
The average flight time from MDE to STI is 2 hours and 40 minutes, covering a distance of 970 mi.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
Book a flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago de los Caballeros from Jose Maria Cordova Intl. Airport (MDE)?
If you're flying on a direct flight from Jose Maria Cordova Intl. Airport (MDE) to Santiago de los Caballeros, Cibao Intl. Airport (STI) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) last-minute?
Holding off until just before your departure to book your flight from MDE to STI generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Keep your travel plans flexible to boost your chances of scoring a bargain.
Is it cheaper to book a MDE to STI flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDE to STI flight and hotel package with Expedia could result in significant savings. What's more, managing everything in one place will take the stress out of planning your trip. Just secure your flights and select from our wide range of stays, then tailor your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
Typically, you're able to cancel or reschedule your MDE to STI flight. However, additional fees may apply, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more information, head to our Customer Service portal.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines
Roundtrip price
$443
Distance
969 mi

Book with confidence

Medellín to Santiago Flights

The cheapest times to fly from Medellín to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santiago are during the month of January. You can find some of the cheapest flights from Medellín to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santiago

Sunday is one of the best days to book for cheap flights from Medellín to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Santiago Flights

Explore a world of travel with Expedia

*Available to One Key members.