$334 Cheap Flights from Minneapolis (MSP) to Panama City (PTY)

View $334 flight on Wed, May 6, 2026Opens in a new window

Popular airlines from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Minneapolis to Panama City (MSP-PTY)

Prices were available within the past 7 days and start at $334 for one-way flights and $604 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Jan 29 - Thu, Feb 5
MSP
Minneapolis
PTY
Panama City
$604 Roundtrip, found 4 hours ago
$604
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Thu, Jan 29 from Minneapolis to Panama City, returning Thu, Feb 5, priced at $604 found 4 hours ago
United
Wed, May 6 - Wed, May 27
MSP
Minneapolis
PTY
Panama City
$604 Roundtrip, just found
$604
Roundtrip
just found
Select United flight, departing Wed, May 6 from Minneapolis to Panama City, returning Wed, May 27, priced at $604 just found
American Airlines
Wed, May 6 - Wed, May 27
MSP
Minneapolis
PTY
Panama City
$608 Roundtrip, just found
$608
Roundtrip
just found
Select American Airlines flight, departing Wed, May 6 from Minneapolis to Panama City, returning Wed, May 27, priced at $608 just found
United
Mon, Mar 23 - Mon, Apr 6
MSP
Minneapolis
PTY
Panama City
$614 Roundtrip, found 1 day ago
$614
Roundtrip
found 1 day ago
Select United flight, departing Mon, Mar 23 from Minneapolis to Panama City, returning Mon, Apr 6, priced at $614 found 1 day ago
United
Wed, May 6 - Wed, May 27
MSP
Minneapolis
PTY
Panama City
$615 Roundtrip, just found
$615
Roundtrip
just found
Select United flight, departing Wed, May 6 from Minneapolis to Panama City, returning Wed, May 27, priced at $615 just found
American Airlines
Wed, May 6 - Wed, May 27
MSP
Minneapolis
PTY
Panama City
$619 Roundtrip, just found
$619
Roundtrip
just found
Select American Airlines flight, departing Wed, May 6 from Minneapolis to Panama City, returning Wed, May 27, priced at $619 just found
United
Mon, Feb 2 - Wed, Feb 11
MSP
Minneapolis
PTY
Panama City
$620 Roundtrip, found 3 days ago
$620
Roundtrip
found 3 days ago
Select United flight, departing Mon, Feb 2 from Minneapolis to Panama City, returning Wed, Feb 11, priced at $620 found 3 days ago
Delta
Tue, Jan 27 - Tue, Feb 3
MSP
Minneapolis
PTY
Panama City
$626 Roundtrip, just found
$626
Roundtrip
just found
Select Delta flight, departing Tue, Jan 27 from Minneapolis to Panama City, returning Tue, Feb 3, priced at $626 just found
Copa
Wed, May 6 - Wed, May 27
MSP
Minneapolis
PTY
Panama City
$720 Roundtrip, just found
$720
Roundtrip
just found
Select Copa flight, departing Wed, May 6 from Minneapolis to Panama City, returning Wed, May 27, priced at $720 just found
avianca
Mon, Jan 5 - Mon, Jan 19
MSP
Minneapolis
PTY
Panama City
$1,119 Roundtrip, found 2 days ago
$1,119
Roundtrip
found 2 days ago
Select avianca flight, departing Mon, Jan 5 from Minneapolis to Panama City, returning Mon, Jan 19, priced at $1,119 found 2 days ago

Find the cheapest month to fly from Minneapolis (MSP) to Panama City (PTY)

August is typically the cheapest month to fly

From $557 - $1,390 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $812
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $812

Frequently asked questions

How much does a flight from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) cost?
Snag a cheap one-way flight from $334 or cheap return flight from $604 from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
January is the least expensive month to fly from MSP to PTY. Planning your trip for the off-season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest MSP to PTY flight.
How many flights per day from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
You'll have to catch a flight with a layover when traveling from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY). There are no daily direct flights on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from MSP to PTY?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a range of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
Opt for a flight from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) that takes off before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) last-minute?
Booking your plane ticket from MSP to PTY right before your getaway is usually more expensive. However, if you're flexible with your departure dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a MSP to PTY flight and hotel package?
Opting for a MSP to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our wide range of accommodations and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
If you booked your MSP to PTY flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
Minneapolis - St. Paul Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$603
Distance
2608 mi

Book with confidence

Minneapolis to Panama City Flights

The cheapest times to fly from Minneapolis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Minneapolis to Panama City are during the month of January. You can find some of the cheapest flights from Minneapolis to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Minneapolis to Panama City

Sunday is one of the best days to book for cheap flights from Minneapolis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Minneapolis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Minneapolis to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $334 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Minneapolis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Minneapolis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Minneapolis to Panama City Flights

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*Available to One Key members.