$866 Cheap Flights from Milan (MXP) to São Tomé Island (TMS)

View $866 flight on Fri, Dec 5, 2025Opens in a new window

Popular airlines from Milan Malpensa Airport (MXP) to São Tomé Island (TMS-São Tomé Intl.)

Cheap Flights from Milan to São Tomé Island (MXP-TMS)

Prices were available within the past 7 days and start at $866 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS) cost?
Lock in a cheap one-way flight from $866 or cheap return flight from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS)?
Traveling in is a good way to save, as it's the cheapest month for flights between MXP and TMS. You'll usually find the lowest prices during the off-season.
What is the cheapest airline that flies from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS)?
To find the cheapest airline that'll fly you from MXP to TMS, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS)?
You'll have to hop on a flight with a layover when traveling from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from MXP to TMS?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change depending on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS)?
To avoid possible delays on the Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS) last-minute?
Booking your plane ticket from MXP to TMS just before your trip is typically more expensive. But if there's some wiggle room with your departure times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a MXP to TMS flight and hotel package?
Opting for a MXP to TMS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Pick from our impressive range of stays and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Malpensa Intl. Airport (MXP) to Sao Tome Intl. Airport (TMS)?
Typically, it's possible to reschedule or cancel your MXP to TMS flight. However, for bookings made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
Malpensa Intl.
Destination airport
São Tomé Intl.
Distance
3128 mi

Book with confidence

Book with confidence

Milan to São Tomé Island Flights

The cheapest times to fly from Milan to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Milan to São Tomé Island are during the month of . You can find some of the cheapest flights from Milan to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Milan to São Tomé Island

Sunday is one of the best days to book for cheap flights from Milan to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Milan to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Milan to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $866 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Milan to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Milan to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Milan to São Tomé Island Flights
*Available to One Key members.