$241 Cheap Flights from Myrtle Beach (MYR) to Missoula (MSO)

View $241 flight on Mon, Jun 15, 2026Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO)

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Cheap Flights from Myrtle Beach to Missoula (MYR-MSO)

Prices were available within the past 7 days and start at $241 for one-way flights and $359 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Nov 18 - Tue, Dec 9
MYR
Myrtle Beach
MSO
Missoula
$359 Roundtrip, found 4 days ago
$359
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Nov 18 from Myrtle Beach to Missoula, returning Tue, Dec 9, priced at $359 found 4 days ago
Delta
Sun, Nov 23 - Tue, Dec 9
MYR
Myrtle Beach
MSO
Missoula
$394 Roundtrip, found 4 days ago
$394
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Nov 23 from Myrtle Beach to Missoula, returning Tue, Dec 9, priced at $394 found 4 days ago
Delta
Tue, Nov 18 - Wed, Dec 3
MYR
Myrtle Beach
MSO
Missoula
$434 Roundtrip, found 4 days ago
$434
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Nov 18 from Myrtle Beach to Missoula, returning Wed, Dec 3, priced at $434 found 4 days ago
American Airlines
Wed, Jun 3 - Mon, Jun 8
MYR
Myrtle Beach
MSO
Missoula
$438 Roundtrip, found 3 days ago
$438
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jun 3 from Myrtle Beach to Missoula, returning Mon, Jun 8, priced at $438 found 3 days ago
American Airlines
Wed, Nov 19 - Thu, Nov 27
MYR
Myrtle Beach
MSO
Missoula
$444 Roundtrip, found 4 days ago
$444
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 19 from Myrtle Beach to Missoula, returning Thu, Nov 27, priced at $444 found 4 days ago
Delta
Wed, Nov 26 - Tue, Dec 9
MYR
Myrtle Beach
MSO
Missoula
$454 Roundtrip, found 4 days ago
$454
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Nov 26 from Myrtle Beach to Missoula, returning Tue, Dec 9, priced at $454 found 4 days ago
Delta
Wed, Dec 17 - Thu, Jan 1
MYR
Myrtle Beach
MSO
Missoula
$458 Roundtrip, found 4 days ago
$458
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Dec 17 from Myrtle Beach to Missoula, returning Thu, Jan 1, priced at $458 found 4 days ago
Delta
Sun, Nov 23 - Wed, Dec 3
MYR
Myrtle Beach
MSO
Missoula
$469 Roundtrip, found 4 days ago
$469
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Nov 23 from Myrtle Beach to Missoula, returning Wed, Dec 3, priced at $469 found 4 days ago
Alaska Airlines
Tue, Dec 9 - Tue, Dec 23
MYR
Myrtle Beach
MSO
Missoula
$758 Roundtrip, found 4 days ago
$758
Roundtrip
found 4 days ago
Select Alaska Airlines flight, departing Tue, Dec 9 from Myrtle Beach to Missoula, returning Tue, Dec 23, priced at $758 found 4 days ago
United
Sat, Feb 21 - Mon, Feb 23
MYR
Myrtle Beach
MSO
Missoula
$817 Roundtrip, found 5 days ago
$817
Roundtrip
found 5 days ago
Select United flight, departing Sat, Feb 21 from Myrtle Beach to Missoula, returning Mon, Feb 23, priced at $817 found 5 days ago

Alternative airports near Missoula

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Missoula Intl. MSO. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $612
MSO
Missoula Intl.
CheapestClosest
Average driving time to city center8 min
Flights from $612

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO) cost?
Get a cheap one-way flight from $241 or cheap return flight from $359 from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO)?
November is the cheapest month to fly from MYR to MSO. Timing your trip outside of the busy season is often the key to better flight prices.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MYR to MSO flight.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO)?
Direct flights from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to MSO?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary depending on a range of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO)?
Select a flight from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO) last-minute?
Holding off until just before your departure to book a flight from MYR to MSO generally means paying more. While it's possible to find some last-minute offers, they're not always guaranteed. Keep your travel schedule open for a better chance of getting a bargain.
Is it cheaper to book a MYR to MSO flight and hotel package?
Opting for a MYR to MSO flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Select from our wide range of stays and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Missoula Intl. Airport (MSO)?
Usually, it's possible to reschedule or cancel your MYR to MSO flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Missoula Intl.
Airlines serving
Alaska Airlines
Roundtrip price
$359
Distance
2043 mi

Book with confidence

Myrtle Beach to Missoula Flights

The cheapest times to fly from Myrtle Beach to Missoula

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Missoula are during the month of November. You can find some of the cheapest flights from Myrtle Beach to Missoula with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Missoula

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Missoula: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Missoula

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Missoula in 2025. You can also book with separate airlines for your outbound and return journeys, from $241 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Missoula flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Missoula airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Missoula Flights

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*Available to One Key members.