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$259 Cheap Flights from Roanoke (ROA) to Indianapolis (IND)

View $259 flight on Sun, Sep 6, 2026Opens in a new window

Popular airlines from Roanoke Regional Airport (ROA) to Indianapolis Intl. Airport (IND)

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Cheap Flights from Roanoke to Indianapolis (ROA-IND)

Prices were available within the past 7 days and start at $259 for one-way flights and $299 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Sep 4 - Tue, Sep 8
ROA
Roanoke
IND
Indianapolis
$299 Roundtrip, found 1 hour ago
$299
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Sep 4 from Roanoke to Indianapolis, returning Tue, Sep 8, priced at $299 found 1 hour ago
Delta
Fri, Sep 4 - Tue, Sep 8
ROA
Roanoke
IND
Indianapolis
$299 Roundtrip, found 1 hour ago
$299
Roundtrip
found 1 hour ago
Select Delta flight, departing Fri, Sep 4 from Roanoke to Indianapolis, returning Tue, Sep 8, priced at $299 found 1 hour ago
United
Fri, Sep 4 - Tue, Sep 8
ROA
Roanoke
IND
Indianapolis
$299 Roundtrip, found 1 hour ago
$299
Roundtrip
found 1 hour ago
Select United flight, departing Fri, Sep 4 from Roanoke to Indianapolis, returning Tue, Sep 8, priced at $299 found 1 hour ago
United
Sat, Sep 12 - Tue, Sep 15
ROA
Roanoke
IND
Indianapolis
$303 Roundtrip, found 1 day ago
$303
Roundtrip
found 1 day ago
Select United flight, departing Sat, Sep 12 from Roanoke to Indianapolis, returning Tue, Sep 15, priced at $303 found 1 day ago
United
Sat, Sep 12 - Tue, Sep 15
ROA
Roanoke
IND
Indianapolis
$305 Roundtrip, found 1 day ago
$305
Roundtrip
found 1 day ago
Select United flight, departing Sat, Sep 12 from Roanoke to Indianapolis, returning Tue, Sep 15, priced at $305 found 1 day ago
American Airlines
Fri, Sep 4 - Tue, Sep 8
ROA
Roanoke
IND
Indianapolis
$314 Roundtrip, found 1 hour ago
$314
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Sep 4 from Roanoke to Indianapolis, returning Tue, Sep 8, priced at $314 found 1 hour ago
United
Sat, Sep 26 - Sun, Sep 27
ROA
Roanoke
IND
Indianapolis
$326 Roundtrip, found 7 hours ago
$326
Roundtrip
found 7 hours ago
Select United flight, departing Sat, Sep 26 from Roanoke to Indianapolis, returning Sun, Sep 27, priced at $326 found 7 hours ago
Delta
Sat, Sep 12 - Tue, Sep 15
ROA
Roanoke
IND
Indianapolis
$328 Roundtrip, found 1 day ago
$328
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 12 from Roanoke to Indianapolis, returning Tue, Sep 15, priced at $328 found 1 day ago
American Airlines
Fri, Sep 4 - Tue, Sep 8
ROA
Roanoke
IND
Indianapolis
$329 Roundtrip, found 1 hour ago
$329
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Sep 4 from Roanoke to Indianapolis, returning Tue, Sep 8, priced at $329 found 1 hour ago
United
Fri, Sep 25 - Sat, Sep 26
ROA
Roanoke
IND
Indianapolis
$334 Roundtrip, found 7 hours ago
$334
Roundtrip
found 7 hours ago
Select United flight, departing Fri, Sep 25 from Roanoke to Indianapolis, returning Sat, Sep 26, priced at $334 found 7 hours ago

Alternative airports near Indianapolis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Indianapolis Intl. IND. Cheapest and Closest option available. Average driving time to city center is 19 minutes. Flights from $314
IND
Indianapolis Intl.
CheapestClosest
Average driving time to city center19 min
Flights from $314

What you need to know for your flight from Roanoke Regional to Indianapolis Intl.

Roanoke (ROA) to Indianapolis (IND) at a glance

Travel from Roanoke (ROA) to Indianapolis (IND) with a range of airlines offering domestic short-haul flights. You can compare options for cheap flights from Roanoke to Indianapolis, selecting from various full-service carriers to find the itinerary that best suits your budget and schedule. Discover the essential details for your journey from Roanoke Regional Airport to Indianapolis International Airport as you prepare to explore the vibrant sights and neighborhoods of Indianapolis.

  • Fastest flight duration: around 3h 15m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 400 miles (645 km)
  • Flights per week: around 9 departures on average
  • Typical fares (one-way): economy tickets often range from $115–$390, depending on seasonality and how far ahead you book

Flights from Roanoke Regional Airport (ROA) to Indianapolis International Airport (IND)

Based on the latest traveler bookings, here are the top airlines favored for one-stop flights from Roanoke to Indianapolis. Popular layover options include Charlotte-Douglas International Airport (CLT) with around a 1 hour and 15 minute layover, O'Hare International Airport (ORD) with about a 1 hour layover, and Hartsfield-Jackson Atlanta International Airport (ATL) offering a 1 hour and 30 minute layover. These choices allow you to balance price, total travel time, and cabin class for the optimal itinerary.

  • American Airlines: This full-service airline provides one-stop itineraries, with one-way ticket prices generally between $115 and $365. It represents roughly 53% of departures on this route, featuring an in-flight duration of 3 hours and 15 minutes, leading to a total travel time of about 4 hours and 30 minutes, including layover.
  • United: Offering one-stop flights, United is a full-service carrier with one-way fares usually ranging from $130 to $545. It accounts for around 28% of the departures for this route, with a flight time of 3 hours and 15 minutes and an overall journey time of about 4 hours and 30 minutes, factoring in the layover.
  • Delta: As a full-service airline, Delta provides one-stop services with one-way fares typically between $115 and $375. It makes up approximately 19% of departures on this route, with a flight duration of 3 hours and 15 minutes and a total travel time of roughly 4 hours and 30 minutes, including layover.

How to find the best prices for flights from Roanoke (ROA) to Indianapolis (IND)

Getting some of the best deals on flights from Roanoke to Indianapolis is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking at least two months in advance, although most travelers typically book two to eight weeks ahead. Evening departures from 6 PM to midnight tend to be less expensive, while morning flights from 5 AM to noon are the most popular. Additionally, flying on Wednesday generally results in lower prices, while Thursday is the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Indianapolis International Airport from Roanoke Regional Airport

Indianapolis welcomes travelers from Roanoke with a range of transport options based on price, convenience, and proximity. Here's how to reach Indianapolis efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Indianapolis, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Indianapolis International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Indianapolis International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Indianapolis International Airport, Indiana University-Riley Station, a metro station, is located about 7.8 miles away.

Frequently asked questions

How much does a flight from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) cost?
You can find cheap one-way flights from $259 and cheap return flights from $299 Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) with Expedia. One-way flights generally range between $280 and $700, and roundtrip flights usually range from $338 to $985. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
September is the cheapest month to fly from Roanoke, VA (ROA) to Indianapolis, IN (IND), with average round-trip fares around $318. This is about 18% lower than the average price throughout the year, likely due to reduced travel demand after the summer. Other budget-friendly months for this route include February and May.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
Enter ROA to IND and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Roanoke Regional (ROA) to Indianapolis Intl. (IND) with a layover in Charlotte-Douglas Intl. (CLT), starting from around $640. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
To find a cheap flight from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
The ideal times to fly from Roanoke (ROA) to Indianapolis (IND) are September and February, with average return flight prices around $318. These months offer a balance of affordability and availability, allowing you to travel without breaking the bank.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
The earliest flight from Roanoke Regional Airport (ROA) to Indianapolis International Airport (IND) usually departs at around 5:00 AM, operated by American Airlines. An early flight like this can help you get a jump on your day in Indianapolis. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
For flights from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.), the most popular departure times are in the early morning, from 6am to 9am. About 40% of passengers choose this time window. Many major carriers, including American Airlines, United Airlines, and Delta, offer flights during this window. This timing is favored because it allows you to arrive in Indianapolis with a full day ahead of you.
How long does it take to fly from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
Flights from ROA to IND with one stop typically take around 4 hours 30 minutes, covering approximately 379 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
First class seats are offered on the ROA to IND route. First class cabins are available on:

  • Delta Air Lines
  • United Airlines
  • American Airlines

How do I earn miles on a Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) flight with Expedia?
It's easy to earn miles on a Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Indianapolis from Roanoke Regional (ROA)?
If you're planning to travel to Indianapolis from Roanoke Regional (ROA), you can fly into Indianapolis Intl. (IND) Some flights may connect through major hubs like Washington Dulles Intl. (IAD), Charlotte-Douglas Intl. (CLT), O'Hare Intl. (ORD) before reaching Indianapolis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) at the last minute?
Typically, booking a last minute flight from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) flight and hotel package?
Securing a Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) Indianapolis Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.)?
If you booked your Roanoke, VA (ROA-Roanoke Regional) to Indianapolis, IN (IND-Indianapolis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Roanoke Regional
Destination airport
Indianapolis Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$298
Distance
379 mi

Book with confidence

Roanoke to Indianapolis Flights

The cheapest times to fly from Roanoke to Indianapolis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Roanoke to Indianapolis are during the month of September. You can find some of the cheapest flights from Roanoke to Indianapolis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Roanoke to Indianapolis

Sunday is one of the best days to book for cheap flights from Roanoke to Indianapolis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Roanoke to Indianapolis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Roanoke to Indianapolis in 2026. You can also book with separate airlines for your outbound and return journeys, from $259 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Roanoke to Indianapolis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Roanoke to Indianapolis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Roanoke to Indianapolis Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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