$476 Cheap Flights from San Francisco (SFO) to Santander (SDR)

View $476 flight on Tue, Aug 19, 2025Opens in a new window

Popular airlines from San Francisco Intl. Airport (SFO) to Santander (SDR)

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Cheap Flights from San Francisco to Santander (SFO-SDR)

Prices were available within the past 7 days and start at $476 for one-way flights and $597 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Mon, Nov 3 - Fri, Nov 14
SFO
San Francisco
SDR
Santander
$597 Roundtrip, found 6 days ago
$597
Roundtrip
found 6 days ago
Select British Airways flight, departing Mon, Nov 3 from San Francisco to Santander, returning Fri, Nov 14, priced at $597 found 6 days ago
British Airways
Mon, Nov 3 - Fri, Nov 14
SFO
San Francisco
SDR
Santander
$613 Roundtrip, found 6 days ago
$613
Roundtrip
found 6 days ago
Select British Airways flight, departing Mon, Nov 3 from San Francisco to Santander, returning Fri, Nov 14, priced at $613 found 6 days ago
British Airways
Mon, Oct 20 - Thu, Nov 6
SFO
San Francisco
SDR
Santander
$625 Roundtrip, found 6 days ago
$625
Roundtrip
found 6 days ago
Select British Airways flight, departing Mon, Oct 20 from San Francisco to Santander, returning Thu, Nov 6, priced at $625 found 6 days ago
American Airlines
Tue, Oct 21 - Thu, Nov 6
SFO
San Francisco
SDR
Santander
$626 Roundtrip, found 6 days ago
$626
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Oct 21 from San Francisco to Santander, returning Thu, Nov 6, priced at $626 found 6 days ago
British Airways
Tue, Nov 25 - Thu, Dec 11
SFO
San Francisco
SDR
Santander
$672 Roundtrip, found 6 days ago
$672
Roundtrip
found 6 days ago
Select British Airways flight, departing Tue, Nov 25 from San Francisco to Santander, returning Thu, Dec 11, priced at $672 found 6 days ago
American Airlines
Sun, Nov 16 - Thu, Dec 4
SFO
San Francisco
SDR
Santander
$673 Roundtrip, found 6 days ago
$673
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Nov 16 from San Francisco to Santander, returning Thu, Dec 4, priced at $673 found 6 days ago
British Airways
Fri, Oct 3 - Wed, Oct 22
SFO
San Francisco
SDR
Santander
$675 Roundtrip, found 6 days ago
$675
Roundtrip
found 6 days ago
Select British Airways flight, departing Fri, Oct 3 from San Francisco to Santander, returning Wed, Oct 22, priced at $675 found 6 days ago
British Airways
Sat, Oct 4 - Wed, Oct 22
SFO
San Francisco
SDR
Santander
$676 Roundtrip, found 6 days ago
$676
Roundtrip
found 6 days ago
Select British Airways flight, departing Sat, Oct 4 from San Francisco to Santander, returning Wed, Oct 22, priced at $676 found 6 days ago
British Airways
Tue, Sep 23 - Wed, Oct 8
SFO
San Francisco
SDR
Santander
$677 Roundtrip, found 6 days ago
$677
Roundtrip
found 6 days ago
Select British Airways flight, departing Tue, Sep 23 from San Francisco to Santander, returning Wed, Oct 8, priced at $677 found 6 days ago
Iberia
Sat, Sep 20 - Fri, Sep 26
SFO
San Francisco
SDR
Santander
$702 Roundtrip, found 2 days ago
$702
Roundtrip
found 2 days ago
Select Iberia flight, departing Sat, Sep 20 from San Francisco to Santander, returning Fri, Sep 26, priced at $702 found 2 days ago
Flights from San Francisco (SFO) to Santander (SDR)
Origin airport
San Francisco Intl.
Destination airport
Santander
Airlines serving
Iberia
Roundtrip price
$596
Distance
5644 mi

San Francisco to Santander Flights

The cheapest times to fly from San Francisco to Santander

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Francisco to Santander are during the month of November. You can find some of the cheapest flights from San Francisco to Santander with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Francisco to Santander

Sunday is one of the best days to book for cheap flights from San Francisco to Santander: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Francisco to Santander

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Francisco to Santander in 2025. You can also book with separate airlines for your outbound and return journeys, from $476 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Francisco to Santander flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Francisco to Santander airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from San Francisco Intl. Airport (SFO) to Santander Airport (SDR) cost?
Get a cheap one-way flight from $476 or cheap return flight from $597 from San Francisco Intl. Airport (SFO) to Santander Airport (SDR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from San Francisco Intl. Airport (SFO) to Santander Airport (SDR)?
The cheapest month to fly from SFO to SDR is November, when demand is low. Off-peak season is often when airlines offer lower prices between these airports.
What is the cheapest airline that flies from San Francisco Intl. Airport (SFO) to Santander Airport (SDR)?
To find the cheapest airline flying from SFO to SDR, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from San Francisco Intl. Airport (SFO) to Santander Airport (SDR)?
You'll have to hop on a flight with a layover if you're traveling from San Francisco Intl. Airport (SFO) to Santander Airport (SDR). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from SFO to SDR?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary depending on a range of factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Francisco Intl. Airport (SFO) to Santander Airport (SDR)?
To reach Santander Airport (SDR) without delays, pick a flight that takes off from San Francisco Intl. Airport (SFO) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Francisco Intl. Airport (SFO) to Santander Airport (SDR) last-minute?
Waiting until just before your departure to book a flight from SFO to SDR generally means paying more. Although you may find some last-minute discounts, they're not always guaranteed. Keep your travel schedule open for the best chance of getting a bargain.
Is it cheaper to book a SFO to SDR flight and hotel package?
Booking a SFO to SDR flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Pick from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from San Francisco Intl. Airport (SFO) to Santander Airport (SDR)?
Generally, it's possible to reschedule or cancel your SFO to SDR flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.