$143 Cheap Flights from Orange County (SNA) to Greenville (GSP)

View $143 flight on Fri, Oct 31, 2025Opens in a new window

Popular airlines from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP)

Cheap Flights from Orange County to Greenville (SNA-GSP)

Prices were available within the past 7 days and start at $143 for one-way flights and $322 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Feb 12 - Sun, Feb 15
SNA
Orange County
GSP
Greenville
$322 Roundtrip, found 5 hours ago
$322
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Feb 12 from Orange County to Greenville, returning Sun, Feb 15, priced at $322 found 5 hours ago
Delta
Wed, Feb 11 - Sat, Feb 14
SNA
Orange County
GSP
Greenville
$328 Roundtrip, found 5 hours ago
$328
Roundtrip
found 5 hours ago
Select Delta flight, departing Wed, Feb 11 from Orange County to Greenville, returning Sat, Feb 14, priced at $328 found 5 hours ago
American Airlines
Thu, Feb 12 - Sun, Feb 15
SNA
Orange County
GSP
Greenville
$330 Roundtrip, found 5 hours ago
$330
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Feb 12 from Orange County to Greenville, returning Sun, Feb 15, priced at $330 found 5 hours ago
Delta
Thu, Nov 27 - Wed, Dec 10
SNA
Orange County
GSP
Greenville
$333 Roundtrip, found 1 day ago
$333
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Nov 27 from Orange County to Greenville, returning Wed, Dec 10, priced at $333 found 1 day ago
Delta
Thu, Nov 27 - Sat, Dec 6
SNA
Orange County
GSP
Greenville
$337 Roundtrip, found 6 days ago
$337
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Nov 27 from Orange County to Greenville, returning Sat, Dec 6, priced at $337 found 6 days ago
Delta
Thu, Nov 27 - Sat, Dec 13
SNA
Orange County
GSP
Greenville
$342 Roundtrip, found 1 day ago
$342
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Nov 27 from Orange County to Greenville, returning Sat, Dec 13, priced at $342 found 1 day ago
United
Mon, Nov 10 - Mon, Nov 17
SNA
Orange County
GSP
Greenville
$359 Roundtrip, found 20 hours ago
$359
Roundtrip
found 20 hours ago
Select United flight, departing Mon, Nov 10 from Orange County to Greenville, returning Mon, Nov 17, priced at $359 found 20 hours ago
American Airlines
Wed, Jan 7 - Mon, Jan 12
SNA
Orange County
GSP
Greenville
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 7 from Orange County to Greenville, returning Mon, Jan 12, priced at $359 found 1 day ago
Southwest Airlines
Thu, Feb 12 - Sun, Feb 15
SNA
Orange County
GSP
Greenville
$367 Roundtrip, found 5 hours ago
$367
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Thu, Feb 12 from Orange County to Greenville, returning Sun, Feb 15, priced at $367 found 5 hours ago
Alaska Airlines
Wed, Apr 15 - Tue, Apr 21
SNA
Orange County
GSP
Greenville
$557 Roundtrip, found 1 day ago
$557
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Wed, Apr 15 from Orange County to Greenville, returning Tue, Apr 21, priced at $557 found 1 day ago

Find the cheapest month to fly from Santa Ana (SNA) to Greenville (GSP)

August is typically the cheapest month to fly

From $248 - $914 per traveler.

Alternative airports near Greenville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Greenville-Spartanburg Intl. GSP. Cheapest option available. Average driving time to city center is 18 minutes. Flights from $453
GSP
Greenville-Spartanburg Intl.
Cheapest
Average driving time to city center18 min
Flights from $453

Frequently asked questions

How much does a flight from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP) cost?
Get a cheap one-way flight from $143 or cheap return flight from $322 from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP)?
February is the most affordable month to fly from SNA to GSP. Avoiding peak travel times is often the key to better flight prices.
What is the cheapest airline that flies from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest SNA to GSP flight.
How many flights per day from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP)?
You'll have to hop on a flight with a layover when traveling from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from SNA to GSP?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP)?
To avoid possible delays on the John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP) route, travel before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP) last-minute?
Last-minute fares from SNA to GSP are generally more expensive. For the best prices, start looking for flights well ahead of time. That being said, if your travel plans are flexible, you may find a cheap fare just before your departure.
Is it cheaper to book a SNA to GSP flight and hotel package?
Compared with arranging hotels and flights separately, booking a SNA to GSP flight and hotel package with Expedia could lead to significant savings. Better yet, managing everything in one place will take the hassle out of travel planning. Just secure your flights and select from our extensive range of hotels, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from John Wayne Airport (SNA) to Greenville-Spartanburg Intl. Airport (GSP)?
If you reserved your SNA to GSP flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
John Wayne
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$321
Distance
2025 mi

Book with confidence

Orange County to Greenville Flights

The cheapest times to fly from Orange County to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Orange County to Greenville are during the month of February. You can find some of the cheapest flights from Orange County to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Orange County to Greenville

Sunday is one of the best days to book for cheap flights from Orange County to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Orange County to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Orange County to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $143 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Orange County to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Orange County to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Orange County to Greenville Flights

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*Available to One Key members.