$129 Cheap Flights from St. Louis (STL) to Greenville (GSP)
Popular airlines from St. Louis Lambert Intl. Airport (STL) to Greenville-Spartanburg Intl. Airport (GSP)
American AirlinesAmerican Airlines
DeltaDelta
Southwest AirlinesSouthwest Airlines
UnitedUnited
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Cheap Flights from St. Louis to Greenville (STL-GSP)
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St. Louis (STL) to Greenville (GSP) at a glance
Discover a range of options for flights from St. Louis (STL) to Greenville (GSP) on this domestic short-haul route. You can compare choices from full-service and low-cost airlines to find the travel itinerary that best suits your budget and schedule as you prepare to explore Greenville's iconic attractions and local neighborhoods. Get all the essential details for flights from Lambert-St. Louis International Airport (STL) to Greenville-Spartanburg International Airport (GSP).
- Fastest flight duration: around 2h 45m in-flight, plus roughly 1h 15m layover with one stop
- Route distance: roughly 500 miles (800 km)
- Flights per week: around 10 departures on average
- Typical fares (one-way): economy tickets often range from $125–$395, depending on seasonality and how far ahead you book
Flights from Lambert-St. Louis International Airport (STL) to Greenville-Spartanburg International Airport (GSP)
Based on the latest traveler bookings, here are the top airlines flying from St. Louis to Greenville, often selected for their one-stop services. Common layover points include Hartsfield-Jackson Atlanta International Airport (ATL) with a layover of about 1 hour and 15 minutes, Charlotte-Douglas International Airport (CLT) with a 1-hour layover, and Nashville International Airport (BNA) also around 1 hour and 15 minutes. This variety allows you to tailor your journey by balancing price, total travel time, and cabin class to find the ideal itinerary.
- American Airlines: As a comprehensive service provider, American Airlines facilitates one-stop flights, with one-way ticket prices generally between $125 and $390. This airline represents around 44% of all departures on this route, featuring a flight duration of 2 hours and 45 minutes, leading to a total travel time of about 4 hours (including layover).
- Delta: This full-service airline offers one-stop journeys, with one-way fares commonly ranging from $145 to $460. Delta handles approximately 36% of the departures on this route, providing an in-flight experience of 2 hours and 45 minutes, culminating in a total travel duration of roughly 4 hours (layover included).
- Southwest Airlines: As a low-cost option, Southwest Airlines provides one-stop travel, with typical one-way fares between $125 and $360. This carrier accounts for around 14% of departures on this route, with an in-flight time of 2 hours and 45 minutes and a total journey time of about 4 hours (including layover).
- United: A full-service airline, United offers one-stop services with one-way fares typically falling between $125 and $405. This airline comprises about 6% of departures on this route, featuring an in-flight duration of 2 hours and 45 minutes, and a total travel time of approximately 4 hours (including layover).
Travelers flying from St. Louis to Greenville can enhance their journey with an upgrade, as Delta provides first-class service on this route.
Best time to fly from St. Louis (STL) to Greenville (GSP)
The most popular months for travelers flying from St. Louis to Greenville are February, March, and April, when peak temperatures in Greenville reach up to 59.9°F in April. If you prefer quieter travel, consider November, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 51.1°F. For better deals, October usually offers the lowest average one-way fare around $208. Flight availability peaks in October, with approximately 12 flights per week, making it easier to find convenient departure times.
- Cheapest time to fly: October usually offers good deals with average one-way fare around $208, roughly 11% cheaper than the yearly average.
- More budget-friendly months to fly: November, May, and August typically offer average one-way fares roughly ranging from $216 to $227.
- Most flight options: October has the highest number of flights from St. Louis to Greenville, with approximately 12 flights per week, giving you more flexibility in scheduling your trip.
| Month | Temperature | Demand | Weekly Flights | Average one-way Fare |
| January | 41.4°F (5.2°C) | Average | 9 | $236 |
| February | 45.3°F (7.4°C) | High | 9 | $237 |
| March | 51.8°F (11.0°C) | High | 9 | $259 |
| April | 59.9°F (15.5°C) | High | 9 | $233 |
| May | 68.4°F (20.2°C) | Average | 9 | $222 |
| June | 76.1°F (24.5°C) | Average | 10 | $227 |
| July | 79.5°F (26.4°C) | Low | 10 | $265 |
| August | 77.5°F (25.3°C) | Average | 11 | $227 |
| September | 72.3°F (22.4°C) | Average | 11 | $230 |
| October | 61.9°F (16.6°C) | Average | 12 | $208 |
| November | 51.1°F (10.6°C) | Low | 8 | $216 |
| December | 45.3°F (7.4°C) | Low | 11 | $260 |
*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.
Alternative routes from St. Louis (STL) to Greenville (GSP)
- St. Louis to Greenville (STL-GMU): Located approximately 8 miles from Greenville-Spartanburg International Airport (GSP), Greenville Downtown Airport (GMU) serves as a convenient option for travelers.
- St. Louis to Greenville (SUS-GSP): Spirit of St. Louis Airport (SUS) is situated roughly 16 miles from Lambert-St. Louis International Airport (STL), providing access for those heading to Greenville.
- St. Louis to Greenville (CPS-GSP): St. Louis Downtown Airport (CPS) is about 16 miles away from Lambert-St. Louis International Airport (STL), making it another viable choice for flights to Greenville.
How to find the best prices for flights from St. Louis (STL) to Greenville (GSP)
Getting some of the best deals on flights from St. Louis to Greenville is all about timing and flexibility. Here are some key tips to help you save:
- Best times to book and fly: cheaper fares are typically found when booking at least two months in advance, although most travelers book their flights two to eight weeks ahead. Afternoon departures from 12 PM to 6 PM usually offer better prices, while morning flights from 5 AM to 12 PM are the most popular. Additionally, flying on Wednesday often provides cheaper options, although Thursday is the busiest travel day.
- Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
- Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Greenville hotel and flight deals.
- Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
- Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
- Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.
*Members only. Savings vary and are not available on all bundles. Select hotels.
Arriving at Greenville-Spartanburg International Airport from Lambert-St. Louis International Airport
Greenville welcomes travelers from St. Louis with a range of transport options based on price, convenience, and proximity. Greenville city center is approximately a 20-minute drive (covering about 16 miles) from Greenville-Spartanburg International Airport, depending on traffic. Here's how to reach Greenville efficiently:
- Hotel transfer: Transfers offer a convenient way to reach your hotel in Greenville, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
- Car rental: Renting a car from Greenville-Spartanburg International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Greenville-Spartanburg International Airport on Expedia.
- Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
St. Louis to Greenville Flights
The cheapest times to fly from St. Louis to Greenville
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Greenville are during the month of December. You can find some of the cheapest flights from St. Louis to Greenville with Expedia's search tool and vast selection of airlines.
The best time to book a flight from St. Louis to Greenville
Sunday is one of the best days to book for cheap flights from St. Louis to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from St. Louis to Greenville
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from $129 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently Asked Questions
How much does a flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) cost?
You can find cheap one-way flights from $129 and cheap return flights $257 St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) with Expedia. One-way flights typically cost between $166 and $767, and return flights often range between $320 and $1001. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) ticket fares go up or down.
*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
August is the cheapest month to fly from St. Louis, MO (STL) to Greenville, SC (GSP), with average round-trip fares around $336. This price is about 16% lower than the average throughout the year, as summer travel often leads to lower demand. Other affordable months to consider are February and September.
*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Enter STL to GSP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
To find a cheap flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
When flying from St. Louis (STL) to Greenville (GSP), consider traveling in August or September, with average return flight prices around $336. These months are not only budget-friendly but also offer a pleasant climate for your visit.
*Prices based on flights available on Expedia in the last year.
What is the earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The earliest flight from Lambert-St. Louis International Airport (STL) to Greenville-Spartanburg International Airport (GSP) departs at around 5:00 AM local time, operated by American Airlines. This service is seasonal, active in November and December, allowing you to start your day early and make the most of your time in Greenville. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The most popular departure times for flights from St. Louis, MO (STL) to Greenville, SC (GSP) are in the early morning, from 6am to 9am. About 32% of passengers prefer this time window. Many major carriers, including American Airlines and Delta, offer flights during this window. This timing is popular because it allows you to start your day early and maximize your time in Greenville.
How long does it take to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Flying from STL to GSP with a connection usually takes about 5 hours 50 minutes, traveling roughly 523 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
First class is available on flights from STL to GSP. First class cabins are available on:
- American Airlines
- Delta Air Lines
- United Airlines
How do I earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight with Expedia?
It's easy to earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.
*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Greenville from Lambert-St. Louis Intl. (STL)?
From Lambert-St. Louis Intl. (STL), you can fly into Pitt-Greenville (PGV) and Greenville-Spartanburg Intl. (GSP) in Greenville. Some flights may connect through major hubs like Ronald Reagan Washington National (DCA) before reaching Greenville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) at the last minute?
Typically, booking a last minute flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package?
Securing a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
If you booked your St. Louis, MO (STL-Lambert-St. Louis Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.
Travel information
Origin airport | St. Louis Lambert Intl. Airport |
|---|---|
Destination airport | Greenville-Spartanburg Intl. Airport |
Distance | 523 miles away |
Airlines serving | American Airlines, Delta, Southwest Airlines, United |
Popular airline | American Airlines |
Roundtrip price | $257 |