$112 Cheap Flights from St. Louis (STL) to Medellín (MDE)

View $112 flight on Sun, Sep 28, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE)

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Cheap Flights from St. Louis to Medellín (STL-MDE)

Prices were available within the past 7 days and start at $112 for one-way flights and $327 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Thu, Aug 21 - Sun, Aug 24
STL
St. Louis
MDE
Medellin
$327 Roundtrip, found 6 days ago
$327
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Thu, Aug 21 from St. Louis to Medellin, returning Sun, Aug 24, priced at $327 found 6 days ago
Spirit Airlines
Thu, Sep 4 - Sun, Sep 7
STL
St. Louis
MDE
Medellin
$330 Roundtrip, found 10 hours ago
$330
Roundtrip
found 10 hours ago
Select Spirit Airlines flight, departing Thu, Sep 4 from St. Louis to Medellin, returning Sun, Sep 7, priced at $330 found 10 hours ago
Spirit Airlines
Thu, Aug 28 - Thu, Sep 4
STL
St. Louis
MDE
Medellin
$333 Roundtrip, found 4 days ago
$333
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Aug 28 from St. Louis to Medellin, returning Thu, Sep 4, priced at $333 found 4 days ago
Spirit Airlines
Thu, Sep 4 - Sun, Sep 7
STL
St. Louis
MDE
Medellin
$337 Roundtrip, found 10 hours ago
$337
Roundtrip
found 10 hours ago
Select Spirit Airlines flight, departing Thu, Sep 4 from St. Louis to Medellin, returning Sun, Sep 7, priced at $337 found 10 hours ago
Spirit Airlines
Sun, Aug 24 - Sun, Aug 31
STL
St. Louis
MDE
Medellin
$353 Roundtrip, found 2 days ago
$353
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sun, Aug 24 from St. Louis to Medellin, returning Sun, Aug 31, priced at $353 found 2 days ago
Spirit Airlines
Thu, Aug 14 - Mon, Aug 18
STL
St. Louis
MDE
Medellin
$358 Roundtrip, found 2 days ago
$358
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Thu, Aug 14 from St. Louis to Medellin, returning Mon, Aug 18, priced at $358 found 2 days ago
Delta
Thu, Oct 23 - Sun, Nov 9
STL
St. Louis
MDE
Medellin
$480 Roundtrip, found 3 days ago
$480
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 23 from St. Louis to Medellin, returning Sun, Nov 9, priced at $480 found 3 days ago
United
Thu, Aug 21 - Sun, Aug 24
STL
St. Louis
MDE
Medellin
$488 Roundtrip, found 6 days ago
$488
Roundtrip
found 6 days ago
Select United flight, departing Thu, Aug 21 from St. Louis to Medellin, returning Sun, Aug 24, priced at $488 found 6 days ago
Copa
Mon, Aug 11 - Sun, Aug 17
STL
St. Louis
MDE
Medellin
$491 Roundtrip, found 6 days ago
$491
Roundtrip
found 6 days ago
Select Copa flight, departing Mon, Aug 11 from St. Louis to Medellin, returning Sun, Aug 17, priced at $491 found 6 days ago
LATAM Airlines Group
Sat, Aug 30 - Sun, Sep 7
STL
St. Louis
MDE
Medellin
$497 Roundtrip, found 4 days ago
$497
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Sat, Aug 30 from St. Louis to Medellin, returning Sun, Sep 7, priced at $497 found 4 days ago

Find the cheapest month to fly from St. Louis (STL) to Medellín (MDE)

January is typically the cheapest month to fly

From $337 - $1,136 per traveler.

Graph displaying average flight prices per month

Alternative airports near Medellín

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Jose Maria Cordova Intl. MDE. Cheapest option available. Average driving time to city center is 29 minutes. Flights from $722
MDE
Jose Maria Cordova Intl.
Cheapest
Average driving time to city center29 min
Flights from $722
Flights from St. Louis (STL) to Medellín (MDE)
Origin airport
Lambert-St. Louis Intl.
Destination airport
José María Córdova Intl.
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, Spirit Airlines, United, avianca
Roundtrip price
$327
Distance
2436 mi

St. Louis to Medellín Flights

The cheapest times to fly from St. Louis to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Medellín are during the month of August. You can find some of the cheapest flights from St. Louis to Medellín with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Medellín

Sunday is one of the best days to book for cheap flights from St. Louis to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Medellín in 2025. You can also book with separate airlines for your outbound and return journeys, from $112 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE) cost?
Discover the latest flight deals from STL to MDE by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from STL to MDE?
The cheapest flights from STL to MDE are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from STL to MDE?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from STL to MDE. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE)?
There aren't any daily direct flights from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time at all.
What day of the week has the most flights from STL to MDE?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE)?
Book a flight from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Booking your ticket from STL to MDE shortly before your trip is generally more expensive. But if you're flexible with your departure times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a STL to MDE flight and hotel package?
Opting for a STL to MDE flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Choose from our impressive range of hotels and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Jose Maria Cordova Intl. Airport (MDE)?
If you reserved your STL to MDE flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

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*Available to One Key members.