$160 Cheap Flights from St. Louis (STL) to Panama City (PTY)

View $160 flight on Wed, Apr 29, 2026Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Tocumen Intl. Airport (PTY)

Cheap Flights from St. Louis to Panama City (STL-PTY)

Prices were available within the past 7 days and start at $160 for one-way flights and $389 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, Apr 1 - Thu, Apr 2
STL
St. Louis
PTY
Panama City
$389 Roundtrip, found 4 days ago
$389
Roundtrip
found 4 days ago
Select United flight, departing Wed, Apr 1 from St. Louis to Panama City, returning Thu, Apr 2, priced at $389 found 4 days ago
American Airlines
Wed, Feb 25 - Thu, Mar 12
STL
St. Louis
PTY
Panama City
$394 Roundtrip, found 4 days ago
$394
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Feb 25 from St. Louis to Panama City, returning Thu, Mar 12, priced at $394 found 4 days ago
Delta
Sun, Feb 1 - Thu, Feb 12
STL
St. Louis
PTY
Panama City
$394 Roundtrip, found 2 days ago
$394
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Feb 1 from St. Louis to Panama City, returning Thu, Feb 12, priced at $394 found 2 days ago
United
Mon, Apr 6 - Mon, Apr 13
STL
St. Louis
PTY
Panama City
$397 Roundtrip, found 15 hours ago
$397
Roundtrip
found 15 hours ago
Select United flight, departing Mon, Apr 6 from St. Louis to Panama City, returning Mon, Apr 13, priced at $397 found 15 hours ago
American Airlines
Tue, Jan 6 - Tue, Jan 13
STL
St. Louis
PTY
Panama City
$398 Roundtrip, found 4 hours ago
$398
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Jan 6 from St. Louis to Panama City, returning Tue, Jan 13, priced at $398 found 4 hours ago
United
Tue, Dec 16 - Thu, Dec 25
STL
St. Louis
PTY
Panama City
$402 Roundtrip, found 2 hours ago
$402
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Dec 16 from St. Louis to Panama City, returning Thu, Dec 25, priced at $402 found 2 hours ago
American Airlines
Wed, Jan 28 - Thu, Feb 5
STL
St. Louis
PTY
Panama City
$403 Roundtrip, found 1 day ago
$403
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 28 from St. Louis to Panama City, returning Thu, Feb 5, priced at $403 found 1 day ago
United
Sun, Jan 25 - Mon, Mar 30
STL
St. Louis
PTY
Panama City
$406 Roundtrip, found 2 days ago
$406
Roundtrip
found 2 days ago
Select United flight, departing Sun, Jan 25 from St. Louis to Panama City, returning Mon, Mar 30, priced at $406 found 2 days ago
Copa
Mon, Nov 24 - Fri, Nov 28
STL
St. Louis
PTY
Panama City
$720 Roundtrip, found 14 hours ago
$720
Roundtrip
found 14 hours ago
Select Copa flight, departing Mon, Nov 24 from St. Louis to Panama City, returning Fri, Nov 28, priced at $720 found 14 hours ago
avianca
Mon, Dec 15 - Wed, Jan 21
STL
St. Louis
PTY
Panama City
$4,304 Roundtrip, found 2 hours ago
$4,304
Roundtrip
found 2 hours ago
Select avianca flight, departing Mon, Dec 15 from St. Louis to Panama City, returning Wed, Jan 21, priced at $4,304 found 2 hours ago

Find the cheapest month to fly from St. Louis (STL) to Panama City (PTY)

July is typically the cheapest month to fly

From $373 - $1,922 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $599
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $599

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) cost?
Get a cheap one-way flight from $160 or cheap return flight from $389 from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
April is the cheapest month to fly from STL to PTY. Traveling outside of peak seasons is often the key to landing a great deal.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from STL to PTY. Then, sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
Direct flights from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from STL to PTY?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary based on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
To land at Tocumen Intl. Airport (PTY) without delays, choose a flight that leaves from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) last-minute?
Waiting until just before your departure to book a ticket from STL to PTY generally means paying more. While it's possible to find some last-minute discounts, they aren't always guaranteed. Keep your travel schedule open to boost your chances of snagging a bargain.
Is it cheaper to book a STL to PTY flight and hotel package?
Securing a STL to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our impressive range of stays and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
If you booked your STL to PTY flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$389
Distance
2160 mi

Book with confidence

St. Louis to Panama City Flights

The cheapest times to fly from St. Louis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Panama City are during the month of April. You can find some of the cheapest flights from St. Louis to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Panama City

Sunday is one of the best days to book for cheap flights from St. Louis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $160 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Panama City Flights

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*Available to One Key members.