$1,885 Cheap Flights from Tampa (TPA) to São Tomé Island (TMS)

View $1,885 flight on Sat, Dec 13, 2025Opens in a new window

Popular airlines from Tampa Intl. Airport (TPA) to São Tomé Island (TMS-São Tomé Intl.)

Cheap Flights from Tampa to São Tomé Island (TPA-TMS)

Prices were available within the past 7 days and start at $1,885 for one-way flights and $2,477 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,477 Roundtrip, found 3 days ago
$2,477
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,477 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,485 Roundtrip, found 3 days ago
$2,485
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,485 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,619 Roundtrip, found 3 days ago
$2,619
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,619 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,629 Roundtrip, found 3 days ago
$2,629
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,629 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,732 Roundtrip, found 3 days ago
$2,732
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,732 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,741 Roundtrip, found 3 days ago
$2,741
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,741 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$2,975 Roundtrip, found 3 days ago
$2,975
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $2,975 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$3,230 Roundtrip, found 3 days ago
$3,230
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $3,230 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$3,345 Roundtrip, found 3 days ago
$3,345
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $3,345 found 3 days ago
JetBlue Airways
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$3,463 Roundtrip, found 3 days ago
$3,463
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $3,463 found 3 days ago
United
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$3,541 Roundtrip, found 3 days ago
$3,541
Roundtrip
found 3 days ago
Select United flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $3,541 found 3 days ago
JetBlue Airways
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$3,547 Roundtrip, found 3 days ago
$3,547
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $3,547 found 3 days ago
TAP Portugal
Sat, Dec 13 - Wed, Dec 17
TPA
Tampa
TMS
São Tomé Island
$3,897 Roundtrip, found 3 days ago
$3,897
Roundtrip
found 3 days ago
Select TAP Portugal flight, departing Sat, Dec 13 from Tampa to São Tomé Island, returning Wed, Dec 17, priced at $3,897 found 3 days ago

Frequently asked questions

How much does a flight from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS) cost?
Grab a cheap one-way flight from $1,885 or cheap return flight from $2,477 from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS)?
Planning your trip for December can help you save, as it's the cheapest month for flights between TPA and TMS. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS)?
To find the cheapest airline that'll fly you from TPA to TMS, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS)?
You'll need to catch a flight with a layover if you're traveling from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from TPA to TMS?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* However, this can change based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS)?
To reach Sao Tome Intl. Airport (TMS) without delays, book a flight that leaves from Tampa Intl. Airport (TPA) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS) last-minute?
Waiting until right before your break to book your flight from TPA to TMS often results in higher prices. While you may come across some last-minute discounts, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of landing a bargain.
Is it cheaper to book a TPA to TMS flight and hotel package?
Compared with arranging hotels and flights separately, booking a TPA to TMS flight and hotel package with Expedia could lead to significant savings. What's more, having it all in one place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of stays, then tailor your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Tampa Intl. Airport (TPA) to Sao Tome Intl. Airport (TMS)?
If you booked your TPA to TMS flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you want more information.

Travel information

Origin airport
Tampa Intl.
Destination airport
São Tomé Intl.
Roundtrip price
$2,476
Distance
6160 mi

Book with confidence

Tampa to São Tomé Island Flights

The cheapest times to fly from Tampa to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tampa to São Tomé Island are during the month of December. You can find some of the cheapest flights from Tampa to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tampa to São Tomé Island

Sunday is one of the best days to book for cheap flights from Tampa to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tampa to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tampa to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,885 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tampa to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tampa to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tampa to São Tomé Island Flights
*Available to One Key members.