Title: Isla Loma Partida Luxury Vacations 2026 | Expedia.com ![](https://images.trvl-media.com/place/6246124/0ff5f005-6032-40dc-9075-f437c081a55f.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Isla Loma Partida Luxury Vacations ## Book a Luxury Hotel + Flight or Car together to unlock savings Photo by Gloria Reichlin - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Top Luxury vacation packages in Isla Loma Partida Price found within the past 48 hours. Click for updated prices. ![Casa Simona](https://images.trvl-media.com/lodging/121000000/120710000/120707000/120706939/2c2e51f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Simona $820 per person Jul 2 - Jul 5 found 5 hours ago Roundtrip flight included Miami (MIA) to Panama City (PTY) No reviews ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista $849 per person Jun 26 - Jul 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (5,182 reviews) Most amazing breakfast ever Reviewed on Apr 7, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco $1,065 per person Jun 26 - Jul 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 8.4/10 Very Good! (1,482 reviews) The room wasn’t the same as the offer. Shower was broken. Casino was good. Low on staff. The overview floor was closed. The pool closes at 7:45pm also the pool bar. Reviewed on Apr 7, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/786350eb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo $1,275 per person Jun 26 - Jul 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,000 reviews) Beautiful boutique hotel. Amazing staff & Great Location Reviewed on Apr 7, 2026 ![Hotel Plaza Herrera](https://images.trvl-media.com/lodging/114000000/113480000/113477600/113477576/68c712fa_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Plaza Herrera Casco Viejo $942 per person May 29 - Jun 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9.8/10 Exceptional! (34 reviews) Internet was good. Suite was spacious. Shower and clothing closet on a seperate floor from bedroom. Ceiling fan was quiet and finctioning. A/C also quiet and functioning. Deck fan operates on a chain that was to short. Hammock on the deck takes alot of space where some decent seating and a small table might be. Great view of the park and street activity. Location is not know to Uber. Early morning coffee is available. Paid for morning breakfast with room online ... used 1 of 2 breakfasts, no credit offered. Breakfast quality is reasonable and tasted good. Staff are probably best asset at this property. They try very hard to make guests welcome amd comfortable. I did not feel like was being worked for an expected tip at all. Reviewed on Mar 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla Loma Partida [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-08/2026-05-15/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=BOC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury vacations in Isla Loma Partida Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista $849 per person Jun 26 - Jul 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (5,182 reviews) Most amazing breakfast ever Reviewed on Apr 7, 2026 ![Hyatt Regency Panama City](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/616200e0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hyatt Regency Panama City Bella Vista $990 per person Jun 26 - Jul 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9.8/10 Exceptional! (217 reviews) The hotel is lovely, it’s a shame that the staff service doesn’t reflect. Our check in process by the check in staff was very cold. I had already messaged the hotel as we had stayed there a few days prior and non of my requests were met. There was a turn down service on our last night there which seemed quite odd as it was offered before. The breakfast was good for a city hotel. Staff have to promoted about hot drinks, the time your drinks arrive you’ve almost finished breakfast. Overall a good stay. Reviewed on Apr 2, 2026 ![W Panama](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### W Panama Bella Vista $1,106 per person Jun 26 - Jul 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,019 reviews) Yes everything met my needs the only thing I didn’t like is that the beds are kinda stiff and I have even seen reviews online about the beds but other than that I enjoyed my time and can’t wait to be back hopefully in December. Reviewed on Apr 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla Loma Partida [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-08/2026-05-15/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=BOC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury vacations in Isla Loma Partida Price found within the past 48 hours. Click for updated prices. ![Casa Simona](https://images.trvl-media.com/lodging/121000000/120710000/120707000/120706939/2c2e51f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Simona $820 per person Jul 2 - Jul 5 found 5 hours ago Roundtrip flight included Miami (MIA) to Panama City (PTY) No reviews ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/786350eb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo $957 per person May 29 - Jun 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,000 reviews) Beautiful boutique hotel. Amazing staff & Great Location Reviewed on Apr 7, 2026 ![Hotel Plaza Herrera](https://images.trvl-media.com/lodging/114000000/113480000/113477600/113477576/68c712fa_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Plaza Herrera Casco Viejo $942 per person May 29 - Jun 1 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9.8/10 Exceptional! (34 reviews) Internet was good. Suite was spacious. Shower and clothing closet on a seperate floor from bedroom. Ceiling fan was quiet and finctioning. A/C also quiet and functioning. Deck fan operates on a chain that was to short. Hammock on the deck takes alot of space where some decent seating and a small table might be. Great view of the park and street activity. Location is not know to Uber. Early morning coffee is available. Paid for morning breakfast with room online ... used 1 of 2 breakfasts, no credit offered. Breakfast quality is reasonable and tasted good. Staff are probably best asset at this property. They try very hard to make guests welcome amd comfortable. I did not feel like was being worked for an expected tip at all. Reviewed on Mar 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla Loma Partida [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-08/2026-05-15/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=BOC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury vacations in Isla Loma Partida Price found within the past 48 hours. Click for updated prices. ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/890b736a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites $535 per person May 16 - May 20 found 1 day ago Roundtrip flight included Kingston (KIN) to Panama City (PTY) 9.4/10 Exceptional! (8 reviews) This is a very nice gated country club. It has great amenities and the apartment is in excellent condition and very comfortable. We only had one issue and that was with the dryer not working, which we didn’t discover until we had already washed a load of clothes. There isn’t a lobby that is staffed at this location, and it’s not clear who to contact with issues. The “check-in” occurred at the security gate as you arrive to the country club. But despite the lack of clear instructions you get when booking, I still recommend this place, especially if you have more than a one night stay, and would stay here again. Reviewed on Mar 16, 2026 ![Hotel Plaza Herrera](https://images.trvl-media.com/lodging/114000000/113480000/113477600/113477576/68c712fa_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Plaza Herrera Casco Viejo $1,074 per person May 21 - May 25 found 1 day ago Roundtrip flight included New York (JFK) to Panama City (PTY) 9.8/10 Exceptional! (34 reviews) Internet was good. Suite was spacious. Shower and clothing closet on a seperate floor from bedroom. Ceiling fan was quiet and finctioning. A/C also quiet and functioning. Deck fan operates on a chain that was to short. Hammock on the deck takes alot of space where some decent seating and a small table might be. Great view of the park and street activity. Location is not know to Uber. Early morning coffee is available. Paid for morning breakfast with room online ... used 1 of 2 breakfasts, no credit offered. Breakfast quality is reasonable and tasted good. Staff are probably best asset at this property. They try very hard to make guests welcome amd comfortable. I did not feel like was being worked for an expected tip at all. Reviewed on Mar 24, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/786350eb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo $1,061 per person Jun 16 - Jun 20 found 1 day ago Roundtrip flight included New York (JFK) to Panama City (PTY) 9/10 Wonderful! (1,000 reviews) Beautiful boutique hotel. Amazing staff & Great Location Reviewed on Apr 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla Loma Partida [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-08/2026-05-15/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=BOC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## All you need to know about luxury vacations in Isla Loma Partida #### What can I expect from a luxury Isla Loma Partida vacation? Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Isla Loma Partida vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. #### How can I find all-inclusive luxury vacation packages in Isla Loma Partida? By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5\* filter to find truly sensational stays. You barely need to lift a finger. #### Can I book a cheap Isla Loma Partida luxury vacation? Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $535\. Prices and availability are subject to change. Additional terms may apply. #### How can I book a luxury family vacation in Isla Loma Partida? Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. #### Can I book a package in Isla Loma Partida with a luxury vacation home? A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package. #### How can I find the best luxury vacation deals in Isla Loma Partida? Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months. #### Can I book a luxury holiday in Isla Loma Partida with free cancellation and/or flexible dates? Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. #### Why should I book my luxury trip to Isla Loma Partida with Expedia? A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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](https://expedia.com/Isla-Loma-Partida-Vacation-Rentals.d3000419307.Travel-Guide-VacationRentals)[ Car Rentals in Isla Loma Partida ](https://expedia.com/Car-Rentals-In-Isla-Loma-Partida.d3000419307.Car-Rental-Guide)[ Isla Loma Partida Vacations ](https://expedia.com/Isla-Loma-Partida.d3000419307.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app