Title: The Best 4 Star Hotels in Santa Ana  | Expedia.com

[Santa Ana Travel Guide](https://expedia.com/Santa-Ana.dx6346884)[Hotels in Santa Ana](https://expedia.com/Santa-Ana-Hotels.d6346884.Travel-Guide-Hotels)[Vacation Rentals in Santa Ana](https://expedia.com/Santa-Ana-Vacation-Rentals.d6346884.Travel-Guide-VacationRentals)[Flights to Santa Ana](https://expedia.com/Cheap-Flights-To-Santa-Ana.d6346884.Travel-Guide-Flights)[Car Rentals in Santa Ana](https://expedia.com/Car-Rentals-In-Santa-Ana.d6346884.Car-Rental-Guide)[Santa Ana Vacation Packages](https://expedia.com/Santa-Ana.d6346884.Destination-Travel-Guides)

![Convento de Santa Ana en Tzintzuntzan México visto detrás de un árbol](https://images.trvl-media.com/place/6346884/68ae534b-f707-443b-86dd-c48d9d24dc07.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Santa Ana 4 Star Hotels

Tonight

[Mar 7 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-07&endDate=2026-03-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 8 - Mar 9](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-08&endDate=2026-03-09&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Learn more about Santa Ana

Venture to Plaza Monumental and Magdalena de Kino City Hall—just two of the sights around Santa Ana.

[See all hotels in Santa Ana](https://www.expedia.com/Hotel-Search?startDate=2026-03-21&endDate=2026-03-22&adults=2&regionId=6346884)

![Convento de Santa Ana en Tzintzuntzan México visto detrás de un árbol](https://images.trvl-media.com/place/6346884/68ae534b-f707-443b-86dd-c48d9d24dc07.jpg?impolicy=fcrop&w=900&h=584&p=1&q=high)

## Top Santa Ana Hotel Reviews

## Find out more about Santa Ana

## Santa Ana Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Santa Ana, Sonora are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Santa Ana 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Santa Ana. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Santa Ana, Sonora, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Santa Ana hotels offer everything your heart desires.

## Explore a world of travel with Expedia

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- [Book 4 Star Hotels in Santa Ana on Expedia.mx ](https://www.expedia.mx/4Estrellas-Santa-Ana-Hoteles.s40-0-d6346884.Guia-Viajes-Filter-Hoteles)