Title: The Best 5 Star Hotels in Santa Ana | Expedia.com [Santa Ana Travel Guide](https://expedia.com/Santa-Ana.dx6346884)[Hotels in Santa Ana](https://expedia.com/Santa-Ana-Hotels.d6346884.Travel-Guide-Hotels)[Vacation Rentals in Santa Ana](https://expedia.com/Santa-Ana-Vacation-Rentals.d6346884.Travel-Guide-VacationRentals)[Flights to Santa Ana](https://expedia.com/Cheap-Flights-To-Santa-Ana.d6346884.Travel-Guide-Flights)[Car Rentals in Santa Ana](https://expedia.com/Car-Rentals-In-Santa-Ana.d6346884.Car-Rental-Guide)[Santa Ana Vacation Packages](https://expedia.com/Santa-Ana.d6346884.Destination-Travel-Guides) ![Convento de Santa Ana en Tzintzuntzan México visto detrás de un árbol](https://images.trvl-media.com/place/6346884/68ae534b-f707-443b-86dd-c48d9d24dc07.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6346884/68ae534b-f707-443b-86dd-c48d9d24dc07.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Ana 5 Star Hotels Tonight [Mar 14 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-14&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 15 - Mar 16](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-15&endDate=2026-03-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6346884&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Ana-Hotels.s50-0-d6346884.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Ana-Hotels.s50-0-d6346884.Travel-Guide-Filter-Hotels) ## Learn more about Santa Ana Venture to San Francisco Chapel and Magdalena de Kino City Hall—just two of the sights around Santa Ana. [See all hotels in Santa Ana](https://www.expedia.com/Hotel-Search?startDate=2026-03-29&endDate=2026-03-30&adults=2®ionId=6346884) ![Convento de Santa Ana en Tzintzuntzan México visto detrás de un árbol](https://images.trvl-media.com/place/6346884/68ae534b-f707-443b-86dd-c48d9d24dc07.jpg?impolicy=fcrop&w=900&h=584&p=1&q=high) ## Top Santa Ana Hotel Reviews ## Find out more about Santa Ana Why not request total luxury on your jaunt to Santa Ana? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Santa Ana so popular in the last year. There's no reason to delay a getaway to Santa Ana any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Reserve one of our 5-star hotels in Santa Ana and indulge in the finer things in life for a while. What are you waiting for? ### Get a Great Deal on 5-Star Hotels in Santa Ana You'll have a wonderful time at one of these 5-star hotels. High-end restaurants, top-notch customer care, and fabulous spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What creature comforts do you want in your lodging? A full-body massage to help your cares fall away? A concierge to help you suggest the next attraction to visit? High thread-count sheets, delectable chocolate desserts, and even space for your family pet in some cases...these hotels will leave you amazed. But you aren't going to spend your entire vacation in your room, of course. Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Santa Ana are waiting for you to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. ### Your Getaway Starts Today The results are in, and Santa Ana 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- Expedia can help you land a great deal on accommodation. Decide on one of the 5-star hotels in Santa Ana today and relax in complete comfort tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Santa Ana? > - Search for the lowest price per night ### What makes a hotel 5 stars in Santa Ana? ### Are there any 5-star all-inclusive resorts in Santa Ana? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - More ways to book - [5 Star Hotels in Magdalena de Kino ](https://www.expedia.com/5Star-Magdalena-De-Kino-Hotels.s50-0-d6346915.Travel-Guide-Filter-Hotels) - [Magdalena de Kino Hotels ](https://www.expedia.com/Magdalena-De-Kino-Hotels.d6346915.Travel-Guide-Hotels) - [Benjamín Hill Hotels ](https://www.expedia.com/Benjamin-Hill-Hotels.d553248635640629488.Travel-Guide-Hotels) - [Magdalena Hotels ](https://www.expedia.com/Destinations-In-Magdalena.d553248635976006520.Hotel-Destinations) - [Vacation Homes in Magdalena de Kino ](https://www.expedia.com/Magdalena-De-Kino-Private-Vacation-Homes.d6346915-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Hotels near Centro Religioso de Nuestra Señora de Maria Magdalena ](https://www.expedia.com/Centro-Religioso-De-Nuestra-Senora-De-Maria-Magdalena-Hotels.0-l553248635975778179-0.Travel-Guide-Filter-Hotels) - [Flights to Magdalena de Kino ](https://www.expedia.com/Cheap-Flights-To-Magdalena-De-Kino.d6346915.Travel-Guide-Flights) - [Centro Religioso de Nuestra Señora de Maria Magdalena ](https://www.expedia.com/Centro-Religioso-De-Nuestra-Senora-De-Maria-Magdalena-Magdalena-de-Kino.d553248635975778179.Vacation-Attraction) - [Visit Magdalena de Kino ](https://www.expedia.com/Magdalena-De-Kino.dx6346915) - [Magdalena de Kino Vacations ](https://www.expedia.com/Magdalena-De-Kino.d6346915.Destination-Travel-Guides) - [Visit Benjamín Hill ](https://www.expedia.com/Benjamin-Hill.dx553248635640629488) - [Car rentals near Magdalena de Kino ](https://www.expedia.com/Car-Rentals-In-Magdalena-De-Kino.d6346915.Car-Rental-Guide) - [Car rentals near Benjamín Hill ](https://www.expedia.com/Car-Rentals-In-Benjamin-Hill.d553248635640629488.Car-Rental-Guide) - [Routes Rental Cars in Magdalena de Kino ](https://www.expedia.com/Routes-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1101.Car-Rental-Guide-Suppliers) - [Car rentals near Centro Religioso de Nuestra Señora de Maria Magdalena ](https://www.expedia.com/Car-Rentals-In-Centro-Religioso-De-Nuestra-Senora-De-Maria-Magdalena.d553248635975778179.Car-Rental-Guide) - [Car rentals near Magdalena de Kino City Hall ](https://www.expedia.com/Car-Rentals-In-Magdalena-De-Kino-City-Hall.d553248635975834391.Car-Rental-Guide) - [National Car Rental Rental Cars in Magdalena de Kino ](https://www.expedia.com/National-Car-Rental-Car-Rentals-In-Magdalena-De-Kino.d6346915-c42.Car-Rental-Guide-Suppliers) - [Essence Car Rental Rental Cars in Magdalena de Kino ](https://www.expedia.com/Essence-Car-Rental-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1085.Car-Rental-Guide-Suppliers) - [First Car Rental Rental Cars in Magdalena de Kino ](https://www.expedia.com/First-Car-Rental-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1107.Car-Rental-Guide-Suppliers) - [Pickup Car Rentals in Magdalena de Kino ](https://www.expedia.com/Pickup-Car-Rentals-In-Magdalena-De-Kino.d6346915-tPickup.Car-Rental-Guide-Class) - [Luxury Car Rentals in Magdalena de Kino ](https://www.expedia.com/Luxury-Car-Rentals-In-Magdalena-De-Kino.d6346915-tLuxury.Car-Rental-Guide-Class) - [Goldcar rental Rental Cars in Magdalena de Kino ](https://www.expedia.com/Goldcar-Rental-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1022.Car-Rental-Guide-Suppliers) - [Mini Car Rentals in Magdalena de Kino ](https://www.expedia.com/Mini-Car-Rentals-In-Magdalena-De-Kino.d6346915-tMini.Car-Rental-Guide-Class) - [Oryx Rent A Car Rental Cars in Magdalena de Kino ](https://www.expedia.com/ORYX-Rent-A-Car-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1059.Car-Rental-Guide-Suppliers) - [Ilha Verde Rental Cars in Magdalena de Kino ](https://www.expedia.com/Ilha-Verde-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1130.Car-Rental-Guide-Suppliers) - [Localiza Colombia Rental Cars in Magdalena de Kino ](https://www.expedia.com/Localiza-Colombia-Car-Rentals-In-Magdalena-De-Kino.d6346915-c1029.Car-Rental-Guide-Suppliers) - [Magdalena de Kino Vacation Rentals ](https://www.expedia.com/Magdalena-De-Kino-Vacation-Rentals.d6346915.Travel-Guide-VacationRentals) - [Book 5 Star Hotels in Santa Ana on Expedia.mx ](https://www.expedia.mx/5Estrellas-Santa-Ana-Hoteles.s50-0-d6346884.Guia-Viajes-Filter-Hoteles)