Santa Ana Vacations from $321

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The Latest Santa Ana vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Colonial Hermosillo
Marsella 45
Hampton Inn by Hilton Hermosillo
Fiesta Americana Hermosillo
Marinaterra Hotel & Spa
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Santa Ana Hotel Deals

Motel Apolo 69

Motel Apolo 69

2 out of 5
km 165 Hermosillo - Magdalena de Kino Santa Ana Son.
Fully refundableReserve now, pay when you stay
$41 nightly
The price is $49 total per night from Nov 12 to Nov 13
$49 total
Nov 12 - Nov 13
Total with taxes and fees
9.2/10 Wonderful! (11 reviews)
"It was the perfect place to stop on our way to puerto Vallarta."

Reviewed on Nov 8, 2026

Motel Apolo 69
Happy Place Plus

Happy Place Plus

Santa Ana Son.
10/10 Exceptional! (1 review)
"The host was amazing, she responded right away. The house was in a great location. There are places to go and eat close by. It was a great experience and we really recommend this place."

Reviewed on Aug 13, 2026

Happy Place Plus
Happy Place

Happy Place

Santa Ana Son.
Happy Place
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Santa Ana Essential Information

Language
Spanish
Currency
Mexican pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
11,900
Max Temp Winter
65ºF
Max Temp Summer
90ºF
Top Sights
Centro Religioso de Nuestra Señora de Maria Magdalena and Magdalena de Kino City Hall

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Frequently asked questions

What's included in a Santa Ana vacation package?
A Santa Ana vacation package lets you combine round-trip flights, hotel stays, and rental cars. Nearly all hotels in Santa Ana offer amenities like free WiFi and air conditioning, contributing to a comfortable stay as you explore this urban destination. Many properties also provide a 24-hour front desk for convenience and are pet-friendly, allowing you to bring your furry companions.

Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
How can I save money on a Santa Ana vacation package?
When you bundle, you can save up to 30%*. To save money on a Santa Ana package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
Is Santa Ana better suited for a beach vacation or a cultural trip?
Santa Ana is primarily an urban destination, known for its city and urban attractions. A Santa Ana vacation can include cultural points of interest such as the Magdalena de Kino City Hall and the Centro Religioso de Nuestra Señora de Maria Magdalena. These sites offer a glimpse into the region's heritage, making it suitable for travelers interested in local history and civic life.
What are the top things to do in Santa Ana?
A Santa Ana vacation offers a chance to explore local civic and religious landmarks:

Browse and book things to do in Santa Ana on Expedia.
Do you need to rent a car in Santa Ana, or is public transport enough?
For Santa Ana vacation packages with flights, renting a car is highly recommended for maximum flexibility. While Santa Ana is an urban destination, key attractions like Magdalena de Kino City Hall and Centro Religioso de Nuestra Señora de Maria Magdalena are located about 17 miles from central Santa Ana, making them easier to reach with your own vehicle.

Additionally, the main airport, Hermosillo, Sonora (HMO-General Ignacio Pesqueira Garcia Intl.), is about 99 miles from central Santa Ana, so a car provides convenient transportation to and from your accommodation. A Santa Ana vacation package that includes a rental car allows you to explore the region at your own pace.
Are Santa Ana vacation package hotels conveniently located?
Santa Ana vacation package hotels offer a mix of central and more spread-out locations. Motel Apolo 69, rated 8.2 out of 10, is conveniently located about 1 mile from central Santa Ana.

Other options, like Hotel Industria and Hotel San Jose, are situated closer to specific attractions such as the Magdalena de Kino City Hall, which is about 17 miles from central Santa Ana. Hotel Industria is about a 10-minute walk from the City Hall, while Hotel San Jose is about 1 mile away. Consider your itinerary when choosing a hotel, as some attractions are a short distance from the city center.
Are there vacation package hotels in Santa Ana within walking distance of restaurants and shops?
For a Santa Ana vacation package, some hotels place you within walking distance of key landmarks, which often feature nearby local amenities.

Hotel Industria is conveniently located about a 10-minute walk from Magdalena de Kino City Hall and about a 5-minute walk from Centro Religioso de Nuestra Señora de Maria Magdalena. Hotel San Jose is also near these sites, about 1 mile from Magdalena de Kino City Hall and about a 15-minute walk from Centro Religioso de Nuestra Señora de Maria Magdalena.

While these distances are to specific landmarks, areas around them typically offer dining and shopping options. Always check the specific location of your chosen hotel on a map to confirm proximity to the amenities you desire.
Can I change or cancel my Santa Ana vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Santa Ana vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Santa Ana vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Santa Ana vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Santa Ana?
To find last-minute vacation packages to Santa Ana, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Santa Ana vacation packages?
Free cancellation on a Santa Ana vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Santa Ana vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Santa Ana getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Santa Ana vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.