Title: The Best 5 Star Hotels in Adrian, MO  | Expedia.com

[Adrian Travel Guide](https://expedia.com/Adrian.dx3000421349)[Hotels in Adrian](https://expedia.com/Adrian-Hotels.d3000421349.Travel-Guide-Hotels)[Vacation Rentals in Adrian](https://expedia.com/Adrian-Vacation-Rentals.d3000421349.Travel-Guide-VacationRentals)[Flights to Adrian](https://expedia.com/Cheap-Flights-To-Adrian.d3000421349.Travel-Guide-Flights)[Car Rentals in Adrian](https://expedia.com/Car-Rentals-In-Adrian.d3000421349.Car-Rental-Guide)[Adrian Vacation Packages](https://expedia.com/Adrian.d3000421349.Destination-Travel-Guides)

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## Check availability on Adrian 5 Star Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=3000421349&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=3000421349&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=3000421349&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=3000421349&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Top Adrian Hotel Reviews

## Find out more about Adrian

## Adrian Five Star Hotel Information

If you’re searching for the celebrity treatment, the 5 star hotels in Adrian are your dreams come true. From sprawling resorts to fancy hot spots, theseAdrian 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for.

Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Adrian, Missouri, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Adrian five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality.

Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Adrian 5 star hotels.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Adrian?

> - Search for the lowest price per night

### What makes a hotel 5 stars in Adrian?

### Are there any 5-star all-inclusive resorts in Adrian?

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