Title: The Best 5 Star Hotels in Santa Isabel | Expedia.com [Santa Isabel Travel Guide](https://expedia.com/Santa-Isabel.dx6175932)[Hotels in Santa Isabel](https://expedia.com/Santa-Isabel-Hotels.d6175932.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel](https://expedia.com/Santa-Isabel-Vacation-Rentals.d6175932.Travel-Guide-VacationRentals)[Flights to Santa Isabel](https://expedia.com/Cheap-Flights-To-Santa-Isabel.d6175932.Travel-Guide-Flights)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d6175932.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.com/Santa-Isabel.d6175932.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Isabel 5 Star Hotels Tonight [Mar 9 - Mar 10](https://www.expedia.com/Hotel-Search?regionId=6175932&startDate=2026-03-09&endDate=2026-03-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=6175932&startDate=2026-03-10&endDate=2026-03-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6175932&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6175932&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Isabel 5-star hotels ![Front of property](https://images.trvl-media.com/lodging/94000000/93500000/93491900/93491844/e6195e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/94000000/93500000/93491900/93491844/50f826be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93500000/93491900/93491844/09861ff0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93500000/93491900/93491844/bc56cff2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Prado Glamping [](https://www.expedia.com/El-Tablon-Hotels-El-Prado-Glamping.h93491844.Hotel-Information) El Tablón 10/10 Exceptional (1 review) "Un lugar hermoso, solo falta dar mas opciones para el check in " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Karla [](https://www.expedia.com/El-Tablon-Hotels-El-Prado-Glamping.h93491844.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Isabel-Hotels.s50-0-d6175932.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Isabel-Hotels.s50-0-d6175932.Travel-Guide-Filter-Hotels) ## Top Santa Isabel Hotel Reviews ## Find out more about Santa Isabel Ready for an incredible adventure? Add further enjoyment on your next trip to Santa Isabel by treating yourself to the best of the best when it comes to accommodation. It's an ideal pairing. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Santa Isabel so popular in the last year. There's no reason to delay a getaway to Santa Isabel any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Santa Isabel and get ready to enjoy the getaway of a lifetime. Don't wait any longer! ### 5-Star Hotels in Santa Isabel You'll have a fantastic time at one of these 5-star hotels. Exceptional customer care, spacious rooms, and rejuvenating spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you suggest the next attraction to visit? Beautiful furniture, piping hot coffees, and even a hot tub in the bathroom...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs. But you aren't going to spend your entire vacation in your room, of course. Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Santa Isabel are waiting for you to relax after an exciting day. ### Your Getaway Starts Today The results are in, and Santa Isabel 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- Expedia can help you land a great deal on accommodation. Select one of the 5-star hotels in Santa Isabel today and relax in total tranquility at your convenience. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Santa Isabel? > - Search for the lowest price per night ### What makes a hotel 5 stars in Santa Isabel? ### Are there any 5-star all-inclusive resorts in Santa Isabel?