If you and your travel companions are searching for a place to stay in Santa Isabel, it may be helpful to be aware that Expedia's booking site of lodgings in Ecuador doesn't currently include accommodations in or near Santa Isabel.
Cuenca is 35 miles from Santa Isabel. It boasts a number of Expedia approved accommodation options including the Mansión Alcázar Boutique Hotel and Hotel Carvallo.
The larger Andes Region region is definitely well worth visiting too. Lovers of the great outdoors will appreciate Andes Region's forests, rivers and streams. You could also go to some of its old towns, churches and history museums. Locals and visitors alike in this part of Ecuador enjoy mountain biking.
If you are a big fan of sports, be sure to catch a match at Estadio 9 de Mayo before you leave Cuenca. Stay nearby at the Hotel Oro Verde Machala.
If you are planning on arriving or departing through Mariscal Lamar Airport, you may choose to book some accommodation at Hotel Oro Verde Cuenca, or Hotel Boutique Santa Lucia, which are both a short distance away.