Book Cairo Bed & Breakfast

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Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22
In one month
Dec 4 - Dec 6
In two months
Jan 1 - Jan 3
No exact matches found, but these alternatives could be just right

Recommended hotels in Cairo

A hotel lobby with a reception desk, seating area, and a large window.

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
$69 nightly
The price is $76
Nov 15 - Nov 16
Total with taxes and fees
Quality Inn Cairo I-57
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

2. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
$66 nightly
The price is $74
Nov 5 - Nov 6
Total with taxes and fees
Eagle Inn Charleston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

3. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (682 reviews)
"Breakfast was light but good"
United States
zandra
$59 nightly
The price is $66
Dec 1 - Dec 2
Total with taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

4. La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (24 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
$57 nightly
The price is $61
Nov 14 - Nov 15
Total with taxes and fees
La Center Motel
A building with a fountain and flower beds in front.

5. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
$66 nightly
The price is $74
Nov 6 - Nov 7
Total with taxes and fees
The Riverstone Hotel Charleston-Sikeston
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

6. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (39 reviews)
"Great place in a beautiful location. "
United States
George B.
$196 nightly
The price is $208
Nov 15 - Nov 16
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake
A compact RV interior with a bed, kitchenette, and seating area.

7. Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.

Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
La Center
$82 nightly
The price is $88
Nov 5 - Nov 6
Total with taxes and fees
Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

8. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
$117 nightly
The price is $123
Nov 7 - Nov 8
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
A small, single-story building with a wooden exterior and large windows.

9. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
$125 nightly
The price is $132
Nov 7 - Nov 8
Total with taxes and fees
The Rested Duck Mallard Room
An aerial view of a river surrounded by dense forest, with a small house near the water's edge.

10. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (6 reviews)
"Great place to stay with our dogs while in town visiting family. We were kept busy by the activities available in the cabin and enjoyed the peace outside. We were tempted to ride the trails, which looked nice, but only didn’t because we opted for mud. High likelihood we will be back. Our dogs were happy and so were we."
United States
Alexia G.
$239 nightly
The price is $253
Nov 8 - Nov 9
Total with taxes and fees
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

11. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
$271 nightly
The price is $290
Nov 5 - Nov 6
Total with taxes and fees
Quiet Country Stay: Modern Home Near Paducah
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

12. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
10.0 out of 10, Exceptional, (4 reviews)
"Host was great. "
United States
Sheila C.
$263 nightly
The price is $282
Nov 5 - Nov 6
Total with taxes and fees
Quiet Country Stay: Modern Home Near Paducah
A modern kitchen with a built-in microwave, stainless steel appliances, and a sink.

13. Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
10.0 out of 10, Exceptional, (26 reviews)
"Location was great. Beds were so comfortable, place was so clean and nice. Very cute place to stay. Would stay here again!"
United States
Deannena H.
$173 nightly
The price is $196
Nov 22 - Nov 23
Total with taxes and fees
Charming Home just minutes from Interstate and Mall
A serene outdoor area with a pond, surrounded by trees and a grassy lawn. There are two wooden benches facing the water.

14. Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (107 reviews)
"The cottage was clean, spacious, had 2 bathrooms (which is uncommon for small cabins). It was very well stocked with kitchen items, and the bath towels were awesome, the bed was very nice. It was peaceful and beautiful. The hostess, Suzie was easy to contact and helpful when we had a question upon checking ìn. I would recommend this place and would stay again if we are in the area!"
United States
Teresa
$243 nightly
The price is $258
Dec 1 - Dec 2
Total with taxes and fees
Charming cottage overlooking Lake Acre
A hot tub in an outdoor setting with a wooden deck and lounge chairs.

15. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
$172 nightly
The price is $180
Nov 5 - Nov 6
Total with taxes and fees
Perfect Couples Retreat - firepit
A hot tub with a wooden deck and outdoor seating area.

16. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
$193 nightly
The price is $203
Nov 11 - Nov 12
Total with taxes and fees
The Roost | Hot Tub, Ponds & Farm Views
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top reviews in Cairo

A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo

10/10 Excellent

Amenities, microwave, refrigerator,iron and iron board,Shower soap options
United States
Maurice
Reviewed February 10, 2026
Quality Inn Cairo I-57

Frequently Asked Questions

Searching for B&Bs in Cairo?

If you're looking for something a little different than your standard hotel experience, a stay at a bed and breakfast could be a great option for your getaway. When you want to explore some attractions in town, Mississippi River and Ohio River Valley are worth a stop.

How do you know if a B&B is the best choice for your stay?

With attentive service, opportunities to meet other guests, and of course a full breakfast to start the day, B&Bs provide a truly one-of-a-kind setting.

When should I book my B&B in Cairo?

When you're planning your stay in Cairo, be sure to take into account the year-round temperatures. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

What is there to do in Cairo?

Spend some time exploring Mississippi River and Ohio River Valley if you're hoping to see some of the area's natural features. You might check out Fort Defiance State Park if you have time to see more of the area.

How can I get to and around Cairo?

You can map out your trip in and around Cairo ahead of time with these transportation options. Fly into Cairo, IL (CIR-Cairo Regional), which is located 4.7 mi (7.5 km) from the heart of the city. Otherwise, look for flights into Paducah, KY (PAH-Barkley Regional), which is 22.9 mi (36.8 km) away. If you'd like to explore around the area, consider renting a car to take in more sights.

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