Cape Girardeau County Vacations & Trips from $642
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Cape Girardeau County Vacation
Travel on your own terms with a vacation package to Cape Girardeau County. Whether you're going for its family-friendly attractions, history, culture, or something else entirely, our package deals make travel planning hassle-free. You can expect to have a to-do list as long as your arm during your trip to Cape Girardeau County. One major city you'll want to spend some time in is Cape Girardeau. Quit dreaming and get packing, because your Cape Girardeau County vacation is only a few clicks away with Expedia.
Top destinations in Cape Girardeau County
Cape Girardeau
Jackson
The Latest Cape Girardeau County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Urban Lofts
$881
per person
Nov 11 - Nov 14
found 13 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
9.4/10 Exceptional! (22 reviews)
Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance.
Reviewed on Jun 11, 2026
Makanda Inn
$851
per person
Nov 11 - Nov 14
found 13 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
10/10 Exceptional! (39 reviews)
I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions.
Reviewed on Jul 22, 2026
Find the Best Cape Girardeau County Vacation Packages
Cape Girardeau County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Top Sights | Cape Rock Park, Cape Girardeau Conservation Nature Center and Lazy L Safari Park |
Cape Girardeau County Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$100 nightly
$113 total
Sep 6 - Sep 7
Total with taxes and fees
The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$104 nightly
$117 total
Sep 30 - Oct 1
Total with taxes and fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
Fully refundable
$105 nightly
$118 total
Sep 3 - Sep 4
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Cape Girardeau County attractions
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Riverfront Bridge Park
8.8/10 (129 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Hunter Valley Winery
7.4/10 (48 reviews)
You can enjoy a tasting or tour at Hunter Valley Winery during your travels to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Riverfront Park
8.0/10 (2 reviews)
Riverfront Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Show Me Center
8.6/10 (40 reviews)
Catch an event at Show Me Center during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Cape Splash Family Aquatic Center
8.6/10 (21 reviews)
Bring the family to Cape Splash Family Aquatic Center and enjoy this exciting amusement park in Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Explore a world of travel with Expedia
Other vacations you might like
- Top cities in Cape Girardeau County
- Vacations and getaways similar to Cape Girardeau County
- Best vacation destinations by month
- January Vacations and Deals
- February Vacations and Deals
- March Vacations and Deals
- April Vacations and Deals
- May Vacations and Deals
- June Vacations and Deals
- July Vacations and Deals
- August Vacations and Deals
- September Vacations and Deals
- October Vacations and Deals
- November Vacations and Deals
- December Vacations and Deals
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
