Cape Girardeau County Vacations & Trips from $680
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Top destinations in Cape Girardeau County
Cape Girardeau
Jackson
Chaffee
Fruitland
Oak Ridge
Altenburg
Whitewater
Gordonville
Delta
The Latest Cape Girardeau County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Oct 15 - Oct 19La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau + Flight
Jackson4 nights3.0 star property9.0/10 - Wonderful (812 reviews)"I can only read a one star rating because when looking up hotels for Jackson Hole, Wyoming, this hotel 20 hours away came up. We asked for a refund and they did not oblige."Reviewed July 24, 2026Roundtrip • Boston (BOS) - Cape Girardeau (CGI)BOS - CGI • 1 stop CGI - BOS • 2 stops$749$680found 1 day agoper traveler - The Riverview
Oct 15 - Oct 19The Riverview + Flight
Cape Girardeau4 nights4.0 star property9.4/10 - Exceptional (633 reviews)Roundtrip • Boston (BOS) - Cape Girardeau (CGI)BOS - CGI • 1 stop CGI - BOS • 2 stops$773$730found 1 day agoper traveler - EC Reed's Mercantile and Hotel
Oct 15 - Oct 19EC Reed's Mercantile and Hotel + Flight
Marble Hill4 nights3.0 star property9.6/10 - Exceptional (103 reviews)"Room was clean staff was very helpful and the French toast was delicious."Reviewed July 21, 2026Roundtrip • Boston (BOS) - Cape Girardeau (CGI)BOS - CGI • 1 stop CGI - BOS • 2 stops$706$683found 1 day agoper traveler - Drury Plaza Hotel Cape Girardeau Conference Center
Oct 15 - Oct 19Drury Plaza Hotel Cape Girardeau Conference Center + Flight
Cape Girardeau4 nights3.0 star property9.6/10 - Exceptional (1,003 reviews)"Nice sized suite room with great amenities."Reviewed July 24, 2026Roundtrip • Boston (BOS) - Cape Girardeau (CGI)BOS - CGI • 1 stop CGI - BOS • 2 stops$822$804found 1 day agoper traveler - Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Oct 15 - Oct 19Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG + Flight
Cape Girardeau4 nights2.5 star property9.4/10 - Exceptional (1,003 reviews)"When we arrived computers system was down, which is understandable, during the stay we had no WiFi the whole time, and our conditioner in room 420 quit working,"Reviewed July 24, 2026Roundtrip • Boston (BOS) - Cape Girardeau (CGI)BOS - CGI • 1 stop CGI - BOS • 2 stops$759$743found 1 day agoper traveler
Discover the most popular places to visit in Cape Girardeau County
Cape Girardeau County Hotel Deals
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO3.0 star property
3.5 mi from Cape Girardeau County
9.6 out of 10, Exceptional, (1,004 reviews)
9.6/10
Exceptional
(1,004 reviews)
"Staff were particularly kind and attentive."
$80 nightly
The price is $85
$85 total
Aug 2 - Aug 3
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
7.2 mi from Cape Girardeau County
9.6 out of 10, Exceptional, (1,003 reviews)
9.6/10
Exceptional
(1,003 reviews)
"Nice sized suite room with great amenities."
$100 nightly
The price is $113
$113 total
Jul 30 - Jul 31
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau3.0 star property
8.3 mi from Cape Girardeau County
9.4 out of 10, Exceptional, (212 reviews)
9.4/10
Exceptional
(212 reviews)
$93 nightly
The price is $105
$105 total
Aug 2 - Aug 3
Total with taxes and fees
Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau2.5 star property
4.5 mi from Cape Girardeau County
9.6 out of 10, Exceptional, (154 reviews)
9.6/10
Exceptional
(154 reviews)
"Brand new place, staff was nice. No complaints"
$89 nightly
The price is $102
$102 total
Aug 2 - Aug 3
Total with taxes and fees
9.4 out of 10, Exceptional, (633 reviews)
9.4/10
Exceptional
(633 reviews)
$114 nightly
The price is $129
$129 total
Aug 3 - Aug 4
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau3.0 star property
3.7 mi from Cape Girardeau County
9.0 out of 10, Wonderful, (812 reviews)
9.0/10
Wonderful
(812 reviews)
"I can only read a one star rating because when looking up hotels for Jackson Hole, Wyoming, this hotel 20 hours away came up. We asked for a refund and they did not oblige."
$84 nightly
The price is $91
$91 total
Jul 28 - Jul 29
Total with taxes and fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG2.5 star property
7.6 mi from Cape Girardeau County
9.4 out of 10, Exceptional, (1,003 reviews)
9.4/10
Exceptional
(1,003 reviews)
"When we arrived computers system was down, which is understandable, during the stay we had no WiFi the whole time, and our conditioner in room 420 quit working,"
$96 nightly
The price is $108
$108 total
Aug 2 - Aug 3
Total with taxes and fees
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West2.5 star property
7.5 mi from Cape Girardeau County
9.0 out of 10, Wonderful, (1,003 reviews)
9.0/10
Wonderful
(1,003 reviews)
$72 nightly
The price is $81
$81 total
Aug 2 - Aug 3
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.