Cape Girardeau Vacations
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Your Cape Girardeau Vacation
Food, history, entertainment and more … There's so much to immerse yourself in with a Cape Girardeau vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's memorable. If sightseeing is on the agenda during your trip to Cape Girardeau, swing by major attractions like Isle Casino Cape Girardeau, Cape Rock Park and Cape Girardeau Conservation Nature Center. Expedia will help you escape your routine. Tailor your vacation to Cape Girardeau to suit your travel style, whatever that may be.
Discover the most popular places to visit in Cape Girardeau
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Isle Casino Cape Girardeau
Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Riverfront Bridge Park
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Cape Girardeau Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Aug 31 to Sep 1
$102 total
Aug 31 - Sep 1
Total with taxes and fees
9.4/10 Exceptional! (1,011 reviews)
"Kickback and breakfast was the best I’ve ever had at any hotel before including service."
Reviewed on Aug 24, 2025
The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $166 total per night from Sep 7 to Sep 8
$166 total
Sep 7 - Sep 8
Total with taxes and fees
9.2/10 Wonderful! (394 reviews)
"This hotel was very pleasant. It was very nice and we liked the casino was downstairs."
Reviewed on Aug 23, 2025
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Aug 28 to Aug 29
$79 total
Aug 28 - Aug 29
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)
"Ok hotel. Good for a single night stop over. Next to outback."
Reviewed on Aug 17, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.