Title: Cape Girardeau Vacation Packages 2026 from $640 | Expedia.com [Cape Girardeau Travel Guide](https://expedia.com/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.com/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.com/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.com/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Car Rentals in Cape Girardeau](https://expedia.com/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide) ![](https://images.trvl-media.com/place/820/34f5c59a-7e57-4244-94c6-c657830fc4ab.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Cape Girardeau Vacations from $640 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Your Cape Girardeau Vacation Food, history, entertainment and more … There's so much to immerse yourself in with a Cape Girardeau vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's memorable. If sightseeing is on the agenda during your trip to Cape Girardeau, swing by major attractions like [Isle Casino Cape Girardeau](https://www.expedia.com/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction), [Cape Rock Park](https://www.expedia.com/Cape-Rock-Park-Cape-Girardeau.d553248621532655781.Vacation-Attraction) and [Cape Girardeau Conservation Nature Center](https://www.expedia.com/Cape-Girardeau-Conservation-Nature-Center-Cape-Girardeau.d553248621532655773.Vacation-Attraction). Expedia will help you escape your routine. Tailor your vacation to Cape Girardeau to suit your travel style, whatever that may be. ## The Latest Cape Girardeau vacation packages Price found within the past 48 hours. Click for updated prices. ![Hampton Inn Carbondale](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/e725ca3d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hampton Inn Carbondale $640 per person Jul 2 - Jul 5 found 1 day ago Roundtrip non-stop flight included St. Louis (STL) to Cape Girardeau (CGI) 8.4/10 Very Good! (630 reviews) Very nice and clean place to stay Reviewed on Mar 28, 2026 ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Riverview $646 per person Jul 2 - Jul 5 found 1 day ago Roundtrip non-stop flight included St. Louis (STL) to Cape Girardeau (CGI) 9.4/10 Exceptional! (537 reviews) Very nice people and 1st class accommodations… only very small downside was our riverview room was directly over parking lot but could see river in distance. Very nice stay , though Reviewed on Apr 6, 2026 ![Comfort Inn & Suites Carbondale University Area](https://images.trvl-media.com/lodging/3000000/2970000/2967300/2967285/ea947cdf_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Comfort Inn & Suites Carbondale University Area $674 per person May 8 - May 10 found 1 day ago Roundtrip flight included Chicago (ORD) to Cape Girardeau (CGI) 7.6/10 Good! (530 reviews) Room was very basic, it was clean. It was missing some furniture a lot of empty space. There was still food in the mini fridge from last guest. Weird smell in hallway on first floor. Parking lot has considerable amount of trash in it. Reviewed on Feb 13, 2026 ![Home2 Suites by Hilton Carbondale](https://images.trvl-media.com/lodging/23000000/22420000/22413300/22413272/6cc7da21_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Home2 Suites by Hilton Carbondale $670 per person May 8 - May 10 found 1 day ago Roundtrip flight included Chicago (ORD) to Cape Girardeau (CGI) 8.8/10 Excellent! (533 reviews) Everything was great for one night stay. Reviewed on Apr 6, 2026 ![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Courtyard by Marriott Cape Girardeau Downtown $684 per person Jul 2 - Jul 5 found 1 day ago Roundtrip non-stop flight included St. Louis (STL) to Cape Girardeau (CGI) 9.6/10 Exceptional! (499 reviews) The staff was very helpful and friendly. The hotel and the rooms were very clean and smelled so good. Would stay here again Reviewed on Apr 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Cape Girardeau [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-05-08/2026-05-15/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=MDH&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ### Discover the most popular places to visit in Cape Girardeau ![Panorama of Academic Hall, Southeast Missouri State University ](https://images.trvl-media.com/place/553248621554122994/3bc9a5e0-c92b-4ca4-b94a-564376156913.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Southeast Missouri State University 4.5/5(78 reviews) Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.com/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) ![View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park](https://images.trvl-media.com/place/553248621532655774/ae18e765-2c28-4c35-b4b0-74f1aaedcb22.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Riverfront Bridge Park 4.5/5(45 reviews) Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.com/Riverfront-Bridge-Park-Cape-Girardeau.d553248621532655774.Vacation-Attraction) #### Century Casino & Hotel Cape Girardeau 4/5(49 reviews) Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.com/Century-Casino-Hotel-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction) ## Cape Girardeau Hotel Deals ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay $100 nightly $113 total Apr 19 - Apr 20 Total with taxes and fees 9.6/10 Exceptional! (1,000 reviews) Had a great experience here. Staff was extremely friendly and interactive. Great location near restaurants, shopping and the mall. Reviewed on Apr 6, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F19%2F2026&endDate=4%2F20%2F2026&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true®ionId=820) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverview 777 Main St Cape Girardeau MO Fully refundableReserve now, pay when you stay $122 nightly $138 total Apr 15 - Apr 16 Total with taxes and fees 9.4/10 Exceptional! (543 reviews) Very nice people and 1st class accommodations… only very small downside was our riverview room was directly over parking lot but could see river in distance. Very nice stay , though Reviewed on Apr 6, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F15%2F2026&endDate=4%2F16%2F2026&selected=105081384&PinnedHotelID=105081384&HadPinnedHotel=true®ionId=820) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Cape Girardeau 3303 Campster Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay $94 nightly $106 total Apr 26 - Apr 27 Total with taxes and fees 9.4/10 Exceptional! (1,007 reviews) Wonderful. I will definitely stay here again. Reviewed on Apr 3, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F26%2F2026&endDate=4%2F27%2F2026&selected=40831&PinnedHotelID=40831&HadPinnedHotel=true®ionId=820) [See all 177 properties in Cape Girardeau](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F9%2F2026&endDate=4%2F10%2F2026®ionId=820) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Cape Girardeau Vacation Packages ## Cape Girardeau Essential Information | Language | English | | --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | U.S dollars | | Closest Airport | Cape Girardeau Municipal Airport (CGI) | | Population | 39,500 | | Max Temp Winter | 45ºF | | Max Temp Summer | 85ºF | | Top Sights | [Cape Splash Family Aquatic Center](https://www.expedia.com/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Vacation-Attraction), [Hunter Valley Winery](https://www.expedia.com/Hunter-Valley-Winery-Cape-Girardeau.d553248621532655783.Vacation-Attraction) and [Steele Crest Winery](https://www.expedia.com/Steele-Crest-Winery-Jackson.d553248621554122992.Vacation-Attraction) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations 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![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations 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book a vacation package to Cape Girardeau? ### Does Expedia offer Book Now, Pay Later Cape Girardeau vacation packages? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near eDen Spa & Salon ](https://www.expedia.com/EDen-Spa-Salon-Hotels.0-l553248621532655776-0.Travel-Guide-Filter-Hotels) - [Hotels near Isle Casino Cape Girardeau ](https://www.expedia.com/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels) - [Hotels near Riverfront Bridge Park ](https://www.expedia.com/Riverfront-Bridge-Park-Hotels.0-l553248621532655774-0.Travel-Guide-Filter-Hotels) - [Hotels near Southeast Missouri State University ](https://www.expedia.com/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels) - [Hotels near Fort D Historic Site ](https://www.expedia.com/Fort-D-Historic-Site-Hotels.0-l553248621532655775-0.Travel-Guide-Filter-Hotels) - [Hotels near Cape Rock Park 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](https://www.expedia.com/lp/flights/mdw/cgi/chicago-to-cape-girardeau) - [Flights from Pensacola (PNS) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/pns/cgi/pensacola-to-cape-girardeau) - [Flights from South Bend (SBN) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/sbn/cgi/south-bend-to-cape-girardeau) - [Flights from Portland (PDX) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/pdx/cgi/portland-to-cape-girardeau) - [Flights from Peoria (PIA) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/pia/cgi/peoria-to-cape-girardeau) - [Eden Spa & Salon ](https://www.expedia.com/EDen-Spa-Salon-Cape-Girardeau.d553248621532655776.Vacation-Attraction) - [Isle Casino Cape Girardeau ](https://www.expedia.com/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction) - [Riverfront Bridge Park ](https://www.expedia.com/Riverfront-Bridge-Park-Cape-Girardeau.d553248621532655774.Vacation-Attraction) - [Southeast Missouri State University ](https://www.expedia.com/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) - [Fort D Historic Site ](https://www.expedia.com/Fort-D-Historic-Site-Cape-Girardeau.d553248621532655775.Vacation-Attraction) - [Cape Rock Park ](https://www.expedia.com/Cape-Rock-Park-Cape-Girardeau.d553248621532655781.Vacation-Attraction) - [Cape Splash Family Aquatic Center ](https://www.expedia.com/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Vacation-Attraction) - [Car rentals near Isle Casino Cape Girardeau ](https://www.expedia.com/Car-Rentals-In-Isle-Casino-Cape-Girardeau.d553248621532655780.Car-Rental-Guide) - [Car rental Scott City Airport (CGI) ](https://www.expedia.com/Car-Rentals-In-Cape-Girardeau-Municipal.d6026978.Car-Rental-Guide) \* Savings based on package bookings compared to the price of the same components booked separately. 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