Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5
See your best vacation deals
See your best vacation deals
See your best vacation deals

Save up to $603 by booking Flight + Hotel.

Search 590,000 properties and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more


Cape Girardeau Vacation Travel Guide

Accommodation in Cape Girardeau

At this point in time, Cape Girardeau doesn't have a wide range of hotels and other types of accommodation featuring on our Cape Girardeau lodging deals page, so make reservations to avoid disappointment.

The Auburn Place Hotel And Suites and Hampton Inn Cape Girardeau I 55 East are the main lodgings in and around Cape Girardeau.

It’s easy to book the getaway of your dreams when you search through our selection of Cape Girardeau vacations. Our goal? To create the perfect trip for you by providing the largest selection of vacation packages. Confidently book your getaway thanks to our trustworthy recommendations and verified consumer reviews from travelers just like you. Personalize your Cape Girardeau package with our myriad of hotel rooms and flight tickets, which help to create a vacation specifically for you. Simply sort through our selection and pick and choose the elements that best suit your preferences and price range.

Because we offer the best rates, you can book your travel reservations knowing you won’t find lower prices elsewhere. These discounts are so great, you’ll feel like you gained the title of the ultimate bargain hunter with our Cape Girardeau vacation package deals. Whether you’re looking to book multiple flights, stay at the fanciest hotel, or explore the hottest local attractions, you’ll find discounted travel arrangements within your budget right here. You shouldn’t have a care in the world when you go on vacation, so our discounts allow you to rest easy without giving your bank account a second thought. Save money on your vacation today and revel in your much-deserved getaway tomorrow.


Top Hotel Deals

See all 29 Hotels in Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center $70
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau
     
    4.1
    of 5, from 559 reviews
    2.5 out of 5.0

    Located in the heart of Cape Girardeau, this hotel is 2.2 mi (3.6 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

    Drury Plaza Hotel Cape Girardeau Conference Center $115
    Drury Plaza Hotel Cape Girardeau Conference Center

    Drury Plaza Hotel Cape Girardeau Conference Center

    3351 Percy Drive, Cape Girardeau
       
      4.8
      of 5, from 75 reviews
      3.0 out of 5.0

      Situated in Cape Girardeau, this hotel is 2.2 mi (3.5 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

      Pear Tree Inn Cape Girardeau West $70
      Pear Tree Inn Cape Girardeau West

      Pear Tree Inn Cape Girardeau West

      103 Cape West Pkwy, Cape Girardeau
         
        4.3
        of 5, from 278 reviews
        2.5 out of 5.0

        Located in the heart of Cape Girardeau, this hotel is 2.8 mi (4.4 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

        Hampton Inn Cape Girardeau I 55 East $101
        Hampton Inn Cape Girardeau I 55 East

        Hampton Inn Cape Girardeau I 55 East

        207 S Mt Auburn Rd, Cape Girardeau
           
          4.9
          of 5, from 137 reviews
          2.5 out of 5.0

          Situated in Cape Girardeau, this hotel is 2.4 mi (3.8 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

          Auburn Place Hotel And Suites $79
          Auburn Place Hotel And Suites

          Auburn Place Hotel And Suites

          3265 William St, Cape Girardeau
             
            4.4
            of 5, from 432 reviews
            2.5 out of 5.0

            Situated in Cape Girardeau, this hotel is 2.3 mi (3.7 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

            Holiday Inn Express Hotel & Suites Cape Girardeau I-55 $109
            Holiday Inn Express Hotel & Suites Cape Girardeau I-55

            Holiday Inn Express Hotel & Suites Cape Girardeau I-55

            3253 William Street, Cape Girardeau
               
              4.8
              of 5, from 397 reviews
              2.5 out of 5.0

              Situated in a rural location, this hotel is 2.2 mi (3.6 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

              Town House Inn Cape Giradreau $54
              Town House Inn Cape Giradreau

              Town House Inn Cape Giradreau

              505 North Kingshighway Street, Cape Girardeau
                 
                2.7
                of 5, from 26 reviews
                2.5 out of 5.0

                Situated in Cape Girardeau, this motel is within 3 mi (5 km) of Cape Splash Family Aquatic Center, Southeast Missouri State University, and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

                Drury Inn & Suites Cape Girardeau $95
                Drury Inn & Suites Cape Girardeau

                Drury Inn & Suites Cape Girardeau

                3303 Campster Drive, Cape Girardeau
                   
                  4.6
                  of 5, from 181 reviews
                  3.0 out of 5.0

                  Located in the heart of Cape Girardeau, this hotel is 2.7 mi (4.4 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University and Isle Casino Cape Girardeau. Lazy L Safari Park and Litz Park are also within 9 mi (15 km).

                  Top Deals on Flights

                  These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.