Centro Histórico Vacations from $969
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The Latest Centro Histórico Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Where to stay in Centro Histórico
Find the best Centro Histórico areas and neighborhoods for the activities you enjoy most. Learn more about Centro Histórico
Equipetrol
Though Equipetrol might not have many top sights, you can venture to the surrounding area to see attractions like Santa Cruz Zoo and Ventura Mall.
Hamacas
While Hamacas isn't home to many top sights, Las Brisas Shopping Center and Santa Cruz Zoo are some notable places to visit nearby.
Urubó
While Urubó might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Guembe Biocenter and Ventura Mall.
Zona Sur (South Zone)
Zona Sur (South Zone) might not have many top sights, but Cine Center and Blacutt Square are two attractions nearby that you can check out.
Centro Histórico Hotel Deals
Hotel Las Américas
Calle 21 de Mayo esq, Seoane N 356 Santa Cruz Santa Cruz Department
Fully refundableReserve now, pay when you stay
$23 nightly
$23 total
Sep 28 - Sep 29
7.8/10 Good! (29 reviews)
"DELICIOSO EL DESAYUNO"
Reviewed on Sep 3, 2026
Lido Hotel
Calle 21 de Mayo 527 Santa Cruz
$25 nightly
$25 total
Oct 3 - Oct 4
Senses Boutique Hotel
Calle 24 de Septiembre, Esq. Sucre No 5 Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Centro Histórico attractions
Plaza 24 de Septiembre
8.8/10 (164 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
San Lorenzo Cathedral
9.0/10 (84 reviews)
One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork.
Arenal Park
7.4/10 (16 reviews)
After visiting Arenal Park, make a plan to see the other sights and activities in Santa Cruz. While in the area, you can find time to visit its shops.
La Recova Artisan Walk
8.8/10 (20 reviews)
During your trip to Santa Cruz, you can search for that perfect souvenir at La Recova Artisan Walk. Make some time to visit the cathedral while you're in the area.
Artecampo
8.8/10 (12 reviews)
During your trip to Santa Cruz, you can enjoy retail therapy at Artecampo. Make some time to visit the cathedral while you're in the area.
Ethno-folkloric Museum
9.0/10 (16 reviews)
You can spend an afternoon studying the exhibits at Ethno-folkloric Museum during your trip to Santa Cruz. While in the area, you can find time to visit its shops.
Franco Aleman Cultural Center
10.0/10 (1 review)
Enjoy an outing to Franco Aleman Cultural Center during your stay in Santa Cruz. While in the area, you can find time to visit its shops.
Sacred Art Museum
8.8/10 (10 reviews)
You can spend an afternoon exploring the galleries in Sacred Art Museum in Santa Cruz. While in the area, you can find time to visit its shops.
Things to do
Santa Cruz and Porongo: History, Markets, River, and Culture
$100
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
$315
per adult
4D/3N Expedition: Che Guevara Route - Disconnect from the World
$799
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.