Santa Cruz Vacations from $316

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Your Santa Cruz Vacation

With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel LP Equipetrol
Camino Real Hotel
Novotel Santa Cruz De La Sierra
Hotel Cortez
Casa Vida
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Discover the most popular places to visit in Santa Cruz

Santa Cruz Hotel Deals

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
$140 nightly
The price is $140 total per night from Aug 12 to Aug 13
$140 total
Aug 12 - Aug 13
8.8/10 Excellent! (390 reviews)
"Great experience . Cannot say enough about the hotel. I will definitely return ."

Reviewed on Jul 8, 2025

Camino Real Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$105 nightly
The price is $105 total per night from Aug 13 to Aug 14
$105 total
Aug 13 - Aug 14
8.8/10 Excellent! (320 reviews)
"Always an amazing hotel"

Reviewed on Jun 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E, Santa Cruz
$75 nightly
The price is $75 total per night from Aug 15 to Aug 16
$75 total
Aug 15 - Aug 16
9/10 Wonderful! (244 reviews)
"Location, surrounding, quietness, good service"

Reviewed on Jul 7, 2025

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
Bolivian bolivianos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Viru Viru Intl. Airport (VVI)
Max Temp Winter
80ºF
Max Temp Summer
90ºF
Top Sights
Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
You'll find cheap prices from $316 on Expedia for your Santa Cruz break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
If you'd like to score a cheap Santa Cruz vacation package, consider traveling in January, May and December. You'll typically find lower rates on hotels and airfares during these quieter months --- ideal for a budget-friendly getaway.
How many days is enough for Santa Cruz?
Generally, a handful of days is enough to tick off the main sights during your Santa Cruz vacation. However, if you prefer to have more time to rest or take day trips, think about extending your trip.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Plaza 24 de Septiembre among the many things to keep you entertained. Whether you're heading away with the family or getting away with friends, a Santa Cruz vacation promises a good time for everyone.
How to find the best Santa Cruz package deals?
Use Expedia's filters to help you find some tempting Santa Cruz package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Santa Cruz package deals in the off-peak season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz escape by booking a personalized vacation package. Click on the "Package" heading, then enter your travel dates and destination to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Cruz?
If you're considering an impromptu Santa Cruz adventure, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find sensational deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you plan to do in Santa Cruz and your preferred season can help you decide when to go.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and dining out to airfares and activities. Your hotel will likely be the largest expense during your trip to Santa Cruz.
  3. Discover Santa Cruz using Expedia's trip planning tool: Gain insights into the leading attractions and best stays for your trip to Santa Cruz. You can also save your favorite places, collaborate with family and friends and manage all your plans in one place.
  4. Decide how long to go for: Now that you're more familiar with Santa Cruz, you can work out the ideal length of your break. Create a rough plan and allocate enough time to cover everything you want to see.
  5. Bundle your accommodations and airfare: Once you've nailed down your dates and duration, lock in the ideal Santa Cruz vacation package for you.
  6. Book experiences or activities in advance: Whether it's a ticket to a major attraction or a day trip, you won't have to worry about missing out on the highlights of Santa Cruz. Find all the incredible things to do in Santa Cruz with our dedicated travel guide.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Your Santa Cruz break is meant to be an escape from your daily routine, not a source of money worries. So to give you a little more flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.