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Your Santa Cruz Vacation
With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.
The Latest Santa Cruz vacation packages

Hotel LP Equipetrol
Reviewed on Feb 21, 2025




Discover the most popular places to visit in Santa Cruz

Plaza 24 de Septiembre
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

San Lorenzo Cathedral
One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork.
Ventura Mall
During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Santa Cruz Hotel Deals

Camino Real Hotel
Reviewed on Jul 8, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Reviewed on Jun 21, 2025

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Reviewed on Jul 7, 2025
Find the Best Santa Cruz Vacation Packages
Santa Cruz Essential Information
Language | Spanish |
---|---|
Currency | Bolivian bolivianos |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Viru Viru Intl. Airport (VVI) |
Max Temp Winter | 80ºF |
Max Temp Summer | 90ºF |
Top Sights | Santa Cruz Zoo, San Lorenzo Cathedral and Sacred Art Museum |
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